Your first mentored grant proposal The National Institutes

Your first mentored grant proposal: The National Institutes of Health F and K proposals Alison K. Hall, Ph. D. Case School of Medicine Office of Graduate Education

Committee on National Needs for Biomedical and Behavioral Scientists, a unit of the National Research Council, the operating arm of the National Academy of Sciences. Estimates that there are some 52, 000 postdocs in the country (2001) 3/4 in life sciences, half from foreign countries

Postdoctoral trainess at Case SOM, Spring 2005 Total SOM Male Female Postdoc Scholar 30 18 12 Postdoc Fellow 81 48 33 Research Associate* 277 160 117 Senior Research Associate* 57 33 24 Many are planning independent careers

Postdocs are at a critical juncture in training productive self-reliant about to embark on independent careers Often write a grant to seek financial support and recognition for their research

Why do you want a mentored grant? 1. Makes the relationship with the PI explicit 2. Benefits associated with grant 3. Looks good on your resume 4. Great learning experience 5. Not ready for the R 01…

Where do you start? Communicate your PI, potential mentors/committee your chairperson the Office of Research Are you ready? pilot data time to focus appointment status deadlines Do you qualify? Not every Institute has these mechanisms Restricted to US citizens, permanent residents

The F 32 NRSA individuals seeking posdoctoral research training in the basic and clinical sciences F 32 ->RO 1 set stipend scale and supplement

The F 32 NRSA February 4, 2005 Stipends for Kirschstein-NRSA awards 2005 Postdoctoral Years of Experience: 0 $ 35, 568 1 $ 37, 476 2 $ 41, 796 3 $ 43, 428 4 $ 45, 048 5 $ 46, 992 6 $ 48, 852 7 or more $ 51, 036 Program announcements http: //grants. nih. gov/training/nrsa. htm Institutional Allowance $5, 500 Research supplies, health insurance, travel to mtgs

The F 32 NRSA is a reasonable goal: Success rates on Individual Postdoc Fellowship applications 2002 Number reviewed MD 202 PHD 1, 336 all 1, 538 number awarded total cost success awarded 1000 s rate* 91 516 607 4, 602 20, 813 25, 415 45 38. 6 39. 5 Percentage that receive funding in a year (a resubmission is only counted the first time) http: //grants. nih. gov/grants/award/training/F 32 MDPHD 9502. HTM

Prepare the Application: read the instructions!! start early, seek internal reviewers a. Candidate (grades, GREs, etc) a. US citizen or permanent resident b. Doctoral degree (many ok) b. Sponsor and Training Environment c. Research Proposal a. Up to 3 yrs c. Training Potential d. Vertebrate Animals, Human Subjects etc. e. 3 times per year, usu Feb 1, June 1, Oct 1 f. The A 1 or A 2. You may have to resubmit… g. http: //grants. nih. gov/training/nrsa. htm

The F 32 NRSA success is about 30% http: //grants. nih. gov/training/data/tf_trends/sld 006. htm

Postdoctoral trainees are funded by many Institutes http: //grants. nih. gov/training/data/tf_trends/sld 006. htm

Case has few F awards Predoctoral (Graduate Students!) 1 F 30 NS 050913 -01 5 F 30 ES 011931 -03 1 F 31 HD 049326 -01 1 F 31 MH 073296 -01 1 F 31 NR 009344 -01 5 F 31 HD 041926 -03 1 F 31 MH 074241 -01 5 F 31 NR 007943 -04 Assistive Device Control With Brain Surface Signals Initiation of Experimental Colitis by Commensal Flora Upper Extremity Control Using Reinforcement Learning Molecular Genetics of the Serotonin System Dance and Physical Activity in African American Women PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES ERK 2 Specific Function of the CNS Kangaroo Care Effects on post/cath stabilization 1 F 32 GM 074554 -01 Creation of designer biogenic amine receptors 1 F 32 AG 024031 -01 A 1 Mechanisms of Abeta-Stimulated ROS in Microglia 5 F 32 EB 003363 -02 Group Theory Applied to rf Coil Design Postdoctoral http: //crisp. cit. nih. gov/crisp_query. generate_screen

Grantwriting Resources Grantpersonship: An Instruction Manual http: //www. pitt. edu/~survival NIMH Grant Application Process http: //www. nimh. nih. gov/research. Funding/grantprocess. cfm http: //www. nimh. nih. gov/research. Funding/training. cfm FASEB Grantsmanship Training Program https: //ns 2. faseb. org/careerutilities/grantprg. htm Grant Application Writer’s Handbook, Reif-Lehrer

The K 08 For clinically trained persons to pursue research careers in basic or clinical sciences. Must apply within 3 years of clinical Training (residency +1 year of clinical fellowship) Mentored Clinical Scientist Development Award K 08 ->K 02 -> R 01 up to $85, 000 salary up to $50, 000 costs per year up to five years, non-renewable

The K 08 Prepare the Application: read the instructions!! a. b. c. d. e. f. g. h. Candidate Research Plan Career Development Plan/ Training Plan Environment/ Institutional support Mentor* Vertebrate Animals, Human Subjects etc. The A 1 or A 2. You may have to resubmit… (The summary statement)

The K 08 1. Candidate** 2. Basic Science Mentor/co Mentor: 1. Good working relationship 2. Often funded by NIH 3. Expert in this area 4. Experienced trainer **some Institutes require faculty appointment (eg Instructor)

The K 08 3. Career Development Plan (very important) • Focused and relevant • New techniques, new area, could be funded • Present at meetings, review grants, external courses • Update didactics • Create an oversight committee familiar with research, career goals, meet six mos for feedback 4. Research Plan • Provide preliminary data to support rationale, approach. Focus! • Include study of Research Ethics, animals etc.

The K 08 http: //grants. nih. gov/grants/guide/pa-files See supplementary info at each institute Insure protected time -Do not assume that 75% means anything except 75% of your total working hours -These estimates are carefully reviewed essential that your chair state this not contingent on receipt of the grant -50% Neurosurgery

What happens to your application after it leaves the mailbox? Scientific Review Group in Center for Scientific Review Study section review supplements Scores and percentiles Summary sheet

Inside the NIH Grant Review Process 39 min video NIH Center for Scientific Review Includes R 01/K 08/ R 03 Download proposals http: //www. drg. nih. gov/Video/video. asp#docs View the video on the web http: //www. drg. nih. gov/Video. asp Helpful Hints for an NLHBI K 08 Application http: //www. nhlbi. nih. gov/funding/training/redbook/hints. htm

K 08 awards at Case 1 K 08 HL 073240 -01 A 1 Medullary GABAergic Neurons in Neonatal Reflex Apnea 5 K 08 AI 001581 -05 CD 8+ T CELLS AND MYCOPLASMA TUBERCULOSIS 5 K 08 CA 084337 -06 ERBB 2 KINASE SIGNALING IN COLON CARCINOGENESIS 5 K 08 DK 059488 -04 The Role of TGF-alpha in the Pathogenesis of ARPKD 5 K 08 DK 002699 -05 QUANTITATIVE EXPRESSION LIBRARIES TO IDENTIFY ESRD GENES 5 K 08 MH 068584 -02 Youth Subjective Experience of Psychotropic Treatment 5 K 08 HL 004299 -05 PULMONARY IMMUNE DEFENCES AGAINST M. BOVIS-BCG INFECTION 5 K 08 AI 054652 -02 Innate immune responses in lymphatic filariasis 1 K 08 HD 047431 -01 Metabolic Requirements for Oogenesis and Embryogenesis 5 K 08 AI 051565 -03 Immunologic Studies of Endemic Burkitt's Lymphoma 5 K 08 NS 046486 -02 Systemic perinatal insults disrupt neurodevelopment 5 K 08 NS 041594 -03 The Role of PPAR Agonists in Inflammation and stroke http: //crisp. cit. nih. gov/crisp_query. generate_screen