Xcell Nutri-Sales P O Box 230 Buccleuch 2066

Xcell Nutri-Sales P O Box 230, Buccleuch, 2066 Tel: 011 -804 -2565; Fax: 011 -802 -7101 Cell: 083 -453 -9055 Web Site: www. xcellsales. co. za E-mail: [email protected] co. za Contact: Bob Cole CEO

WELCOME TO THE PRESENTATION ON PHYTO BACILLUS

INTRODUCTION AND BACKGROUND

BACKGROUND • • • DSM Lafti Acidophilus L 10 Bifida Bacteria

SECOND GENERATION PROBIOTIC (Lafti L 10) • Compatibility – Human GI Tract, Therapeutic Efficiency • Concentration – 1. 5 Billion • Stability – 1 Year • Viability – Stomach Acid & Bile Survival (9)

Survival of LAFTI L 10 in comparison with other strains (in gastrointestinal model)

THERAPEUTICS 1 • • Listeria (6, 7 &13) Cancer (8) Gut Disturbances (10, 11 &12) Antihypertensive Peptides Inhibits Range Of Pathogenic Bacteria Produces Lactose Good Adhesion To Intestinal Mucus Promotes Health & Wellbeing

Inhibition of Listeria in vitro Mahoney et al. (2003) International Journal of Food Microbiology (in press) 84: 255 -261

LAFTI® reduces incidence of cancer Control LAFTITML 10 GG Incidence of tumour formation (%) 40 15 20 Large intestinal tumours (no. ) 10 31 4 Tumour mass index (log 10) 1. 7 0. 12 1. 9 statistically different from the control at 5% level (Chi test); 2 statistically different from all other treatments (P<0. 05) 1 Mc. Intosh et al. (1999) Nutrition and Cancer 35: 153 -159

Effect of LAFTI® L 10 on gut disturbances (UNSW) • Placebo controlled, randomized, cross-over study • Subjects (n = 60) treated with LAFTI® L 10, Lactobacillus sp. and placebo for 2 weeks Two weeks wash out between treatments Questionnaires completed at the end of each treatment week

How treatment with LAFTI® was perceived Do you think that the capsules have a beneficial effect? * Welin et al, UNSW, evaluation completed Q 42003 * Significantly different from the placebo (P < 0. 05)

LAFTI® L 10 reduces gastrointestinal disturbances Have you experienced any of the following gut disturbances while taking the capsules? (circle the number that best describes the severity of the condition: 1 = low, 10 = severe). Welin et al, UNSW, evaluation completed Q 42003 * Significantly different from the placebo (P < 0. 03)

Study in mice – conclusions Conclusion • LAFTI L 10 clears yeast (Candida) infection rapidly • LAFTI L 10 restores low levels of IFN- Ø Rapid clearance of Candida correlates with the increase of IFN- LAFTI L 10 may be used in restoration of a suppressed immune system and help with protection against Candida infection

STIDY IN HUMANS - conclusions Conclusions • Lafti L 10 restores low levels of IFN-y • There are strong indications that LAFTI L 10 reduces EBV infection (further studies are needed to confirm reduction of EBV infection by LAFTI L 10) LAFTI L 10 may be used in restoration of a suppressed immune system. As a result LAFTI 10 may help in the protection against EBV infection and fatigue related to this infection.

Phyto Bacillus – Candida/CD 4/Weight • GI Tract Compatibility • Significant Reduction In Severity Of Candida • Improved CD 4 Count • Improvement In Weight • More detailed research is needed

Conclusions • Fatigued athletes have significantly lower IFN-g levels than healthy athletes • Intake of LAFTI L 10 increases INF- levels • Intake of LAFTI L 10 has a restorative effect on IFN-g levels in fatigued athletes Ø This pilot study suggest that LAFTI L 10 may be useful in restoration of a suppressed immune system.

Important properties of LAFTI • Are perceived as having a beneficial effect on general health (L 10) • Alleviates symptoms of a wide range of gut disturbances (L 10) • Reduce survival of Listeria in the GI tract of animals L 10 • Inhibit range of pathogenic bacteria in vitro (L 10, L 26, B 94) • Protect against small and large intestinal cancers in animals (L 10) • Produce antihypertensive peptides (L 10, L 26, B 94) • Produce lactose (L 10, L 26, B 94) • Good survival in capsules (L 10, L 26, B 94) • Contribute to increased food safety (L 10, L 26, B 94)

PREBIOTIC Fructo Oligosaccharide (FOS) • Nutritional Base For Bacillus • Fibre Base Promotes Colonization • p. H Balance Promotes Colonization • NOTE • Probiotics should be combined with broad spectrum dietary fiber for optimum therapeutic efficiency

PHYTO BACILLUS • Developed In South Africa In Consultation With DSM • Clinical Trials – University Of The Orange Free State – In Progress • Phyto Bacillus – Advanced Technology, Therapeutic Efficiency - Integrity

SYNBIOTICS

SYNBIOTICS - 1 • • • GI TRACT Indigestion, Heart Burn Reflux, Diarrhea, Constipation Irritable Bowel & Leaky Gut Syndromes Ulcerous Colitis & Ulcers, Crohn’s Disease • Gastrointestinal Infections • Food Allergies

SYNBIOTICS 2 • IMMUNE SYSTEM • Reestablishes Bacterial Efficiency – Antibiotics, Chemo & Radiation Therapies, Anti-Inflammatories, ARV’s • Increases Immunoglobulin A • Increases Non Specific Antigens (Phagocytic Activity) • Liver Dysfunction & Liver Related Brain Dysfunction

SYNBIOTICS 3 • CANCER • Inhibits Growth Rate Of Tumors • Inhibits Bacteria That Convert Matter Into Carcinogens • Binds And Inactivates Some Carcinogens • Builds Non Specific Antigens – (Phagocytic Activity) • Increases Immunoglobulin A Count

SYNBIOTICS 4 • HEART & CARDIOVASCULAR • Lowers Triglycerides, LDL Cholesterol & Total Cholesterol • Reduces Serum Fat And Blood Sugars • Hypertension • Diabetes

USAGE • Nutrition Not Medication • Treating Causes Not Disease Symptoms • Most Synbiotic Applications Need Long Term Therapeutic Usage Of At Least Thirty Days i. e. One Jar, To Address Dysfunction • Safe For Children (1 Year & Older), Pregnant and Lactating Mothers • Safe In Higher Usage Applications, Under Supervision Of Physician/Doctor/Health Practitioner

USAGE Cont. • Two Capsules Per Day • Optimum Therapeutic Benefit – Half An Hour Before Meals – Otherwise With Meals • Safe For Long Term Usage – More Than a Month • Store At Below 25%C • Store Under In Refrigerator After Opening Pack

COMMERCIAL

Retail Pharmacy Prices • COST • 1 to 9 Units - R 109. 76 ea • * Bonus Offer • Buy 10, Get 1 Free • Cost R 1 097. 60 • SELLING • 1 to 9 Units - R 164. 63 ea • Mark Up On Cost = 50% • * Bonus Offer • Buy 10, get 1 Free • Turnover = R 1 810. 93 • Mark Up On Cost = 65% • * Per 10 Capsules Dispensed @ R 29. 90 • Mark Up On Cost = 80%

ORDERS • PRIMARY NATIONAL DISTRIBUTOR • Medi-Focus – 011 -201 -6000 • Transfarm – UPD • Other Wholesalers

REGISTRATIONS • • • MCC – Submitted – Schedule S 0 NAPPI Code – 704859 -001 Barcode - All Stock Wholesalers Listings – Under Negotiation Store At Below 25%C Store In Refrigerator Once Pack Is Opened

THANK YOU FOR GOING THROUGH THIS PRESENTATION WITH US WE LOOK FORWARD TO DOING BUSINESS WITH YOU