Virtual Patient Ltd Final exam in internal medicine

Virtual Patient Ltd. Final exam in internal medicine utilizing VP System at the Faculty of Medicine, Technion (Israel Institute of Technology) July 2014 Page 1 Virtual Patient Ltd. Confidential March 2015

Introducing Virtual Patient Ltd. has developed a unique system- the VP System- which is an interactive software designed to provide a complete E-Learning and E-Assessment environment for any Medical Education Institution. VP System simulates interactively routine dialogues between doctors and patients, based on written interface and natural language recognition. VP System is the only product in the market offering med students to acquire clinical reasoning, decision making skills and complete patient management. The VP System has been utilized by The Technion- Israel Institute of Technology, for training and assessment of more than 1, 000 med students over the last 9 years. The VP system serves as the standard learning and testing facility of the Internal Medicine department at the Ruth and Bruce Rappaport Faculty of Medicine, Technion. md. technion. ac. il www. technion. ac. il/en Page 2 Virtual Patient Ltd. Confidential March 2015

Introducing Virtual Patient We envision that the extensive usage of VP System will result in producing more physicians and other medical staff faster, more efficiently, at lower cost, maintaining high quality of medical standard Creating gold standard for medical education Improving the cost efficiency of medical education Expanding the accessibility of medical education Decreasing the health services gap between developed and undeveloped countries The Company was recently founded in order to commercialize this solution globally. The VP System has substantial potential to be utilized in other domains, both medical related and non medical related, offering an effective E- Learning and E-Assessment tool. Potential domains include: home security, military, corporate training, aviation & automobile industries, human resources screening, etc. Page 3 Virtual Patient Ltd. Confidential March 2015

The need Regular written exams test only theoretical knowledge, which is insufficient for medical studies of doctors and other related professions. There is a need for a system that will simulate complete patient management, as interactions with real patients are very limited. The current practice The most common modes of examination are pen & paper multiple choice exams, oral exams and Objective Structured Clinical Examinations (OSCE). Pen & Paper multiple choice exams evaluate mainly knowledge. Oral exams have low reliability. To improve reliability, each student has to be evaluated by several experienced, independent examiners, rendering this mode of examination impractical. OSCE are complex and costly. They are based on simulation of patients by actors and therefore require massive resources and may lack some of the patient management stages. Other disadvantages include complicated logistics and biased scoring. Page 4 Virtual Patient Ltd. Confidential VP System OSCE Pen & Paper and Oral exams March 2015

The product VP System is a web based tool which allows students to train at their own time from anywhere. Based on linguistic patterns, keywords and AI (artificial intelligence) algorithms, the VP system enables the user to "talk" to the virtual patient in plain language and responds to the user's questions in the same manner. The goal of the user is to ask a series of relevant questions in order to reach his diagnosis. The VP System is comprised of separate modules, which enable to add easily infinite data cases of any domain in any language. During the first 3 years, the VP System was performed in the Technion parallel with traditional OSCE method and was proven to have high statistical reliability. The VP System allows complete simulation of patient management including anamnesis, physical examination, imaging, laboratory testing and treatment for a wide variety of medical cases At training mode, students may receive feedback and mentoring on performed activities At exam mode the user is assigned a pre-determined selection of cases, which change when the assigned time for each case expires. A Advantageous Page 5 Virtual Patient Ltd. A A Affordable Accessible Confidential March 2015

(validity and reliability) VP System OSCE exams Low Quality High VP System vs. current exam methods Pen & paper exams Oral exams Low Cost High VP System offers a comprehensive solution reflecting the best value in terms of both quality and cost Page 6 Virtual Patient Ltd. Confidential March 2015

Competition Virtual Patient Criteria Thera. Sim Medizinische Fakultät Med U Heidelberg (CASUS) CAMPUS Virtual Patients Group Web based platform OSCE compatibility Real-life dynamic case scenario Complete independent patient management Medical reasoning /competence /professionalism Free form language conversation based Multiple choice scenarios Self-exercise / training mode E-assessment mode Page 7 Virtual Patient Ltd. Confidential March 2015

Competition cont. Virtual Patient Criteria Thera. Sim Medizinische Fakultät Med U Heidelberg (CASUS) CAMPUS Virtual Patients Group Statistical analysis of examination results Creation of case studies by user Multilingual adaptability Partial Proven experience in academic environment Platform adaptability to other educational fields Partial Basic (Advanced GUI under development) GUI Page 8 Virtual Patient Ltd. Good Confidential Basic VP System is the only product in the market offering a full comprehensive solution Basic 3 D /mannequin March 2015

The market E-Learning is a multi-billion market with significant growth forecasts ► ► ► The global E-Learning expenditure was valued by IBIS Capital in 2012 at $91 billion. K-12 and post-secondary (higher education or HE) are two key sectors of the educational market and they regularly attract a great deal of attention from both private companies and governmental institutions. E-Learning market will show fast and significant growth over the next three years. Ibis forecast that the total E- Learning expenditure will reach $256 representing a CAGR of 23% for the period billion in 2017, 2012 -2017. Source: Docebo 2014 Large and affirmed companies Global (such as the primary 5000) are the buyers of E-Learning products and services. They account for more than 30% of the E-Learning Market clientele. The market is highly decentralized in both sides- buyers and providers, which reflects an opportunity for new players to enter the market. 40% of the E-Learning providers entered the market after 2009 while the Top 5 companies comprise of less than 4% of the market. Source: IBIS 2014 Page 9 Virtual Patient Ltd. Confidential March 2015

World med schools and graduates The market World medical schools at target countries Russia 68 UK 47 France 53 USA 170 Spain 37 World med schools: approx. 2, 400 2014 China 179 India 355 Source: International Medical Education Directory (IMED) Medical graduates per 100 000 population 25. 0 20. 0 15. 0 10. 0 5. 0 Austria Denmark Ireland Netherlands Greece Czech Republic Iceland Portugal Mexico Australia Germany United Kingdom Finland Hungary Norway Italy OECD Belgium Slovenia Switzerland Estonia Spain Poland Sweden Slovak Republic Korea New Zealand Canada Turkey United States Chile France Japan Israel 0. 0 Source: OECD Health Data 2011 Page 10 Virtual Patient Ltd. Confidential March 2015

Strategy and Milestones Year 1 Year 2 Increased marketing efforts, including primary publications in professional journals, in order to reach customers in 25 institutions abroad. Initial penetration into nursing and paramedicine fields. Development of mobile and expansion patches and features + software DB + translation to 4 additional languages. Year 3 Increased marketing with target of 235 customers in overseas institutions. Completion of the remaining development and expansion of case database in all fields. Development of new cases applicable for medical internship programs. Year 4 Continuous operation, expanding case database and variety, customers in 580 overseas institutions and initial penetration into dentistry. Year 5 Page 11 Further system development (incl. GUI, adding cases to existing 200 cases in internal medicine, complete translation to English, development of surgery, pediatrics and gynecology). Marketing- first customers in 3 institutions. Efforts will also be focused on conferences and creating initial awareness. . Continuous operation, expanding case database and variety, customers in 1, 480 overseas institutions. Initial penetration into pharmacology and veterinary. Virtual Patient Ltd. Confidential March 2015

Model Assumptions Model assumptions Projected headcount The financial model is based on assimilating the Company's proven platform into multiple medical schools, both in high-income and middle to low- income countries. Significant growth is also based on further transformation of VP System into more educational fields, including dentistry, Nursing, Pharmacology, Paramedicine and Veterinary. Revenue assumptions are based on penetration to a few leading institutions in the first two years, followed by fast adoption onward. To date, Virtual Patient has developed a working software product that has been successfully implemented in The Technion. Israel Institute of Technology. Funding Uses Y 1 Y 2 Y 3 Y 4 Y 5 CEO 1 1 1 COO CTO CMO (Chief Medical Officer) CFO MD professional Graphic Designer SW Developer Data Developer (MDBA) Account manager: pre sale Account manager: post sale Administration staff 1 1 0 0 1 1 2 2 1 0 1 1 1 2 2 3 0 2 1 1 3 2 10 6 3 1 1 3 2 23 16 4 1 1 3 2 64 42 9 11 18 34 58 130 Y 1 3 0. 1% 0 3 Y 2 Y 3 75 3. 2% 160 235 Y 4 150 6. 3% 430 580 Y 5 Total Client forecast R&D: Case preparation for various medical and educational fields, improved GUI and mobile platform development. M&S: Establishment of global marketing activities and sales. G&A: Setting the operations and customer support globally. Page 12 Employees Virtual Patient Ltd. Clients Medical Institutions Market Share Other medical related institutions Total Institutions Confidential 15 0. 6% 10 25 March 2015 200 8. 4% 1, 280 1, 480

Financial Forecast P&L 5 year forecast Currency: $000 FY 1 Total revenues Cost of Sales 376 Gross profit (loss) Sales and Marketing Research and Development General and Administrative (299) 186 796 423 FY 4 FY 5 1, 317 77 FY 2 10, 176 27, 868 57, 228 875 1, 694 2, 870 6, 192 442 8, 482 24, 998 51, 036 392 1, 128 908 1, 196 1, 366 1, 621 2, 537 1, 386 2, 016 6, 366 1, 406 2, 897 Total Cost (1, 780) (3, 303) (5, 877) (8, 808) (1, 703) (1, 986) 4, 299 19, 060 40, 367 Cumulative profit (1, 703) (3, 689) 611 19, 670 reserve, assuming no sales) (16, 861) Operational profit (loss) Funding requirement for 3 years of operation: $12 m (incl. $1 m 60, 037 Page 13 Virtual Patient Ltd. Confidential March 2015

The management Professor Arie Oliven Dr. Adam Baruch Co-founder ► ► ► Director, Department of Internal Medicine, Bnai Zion Medical Center in Haifa. Chairman of Internal Medicine and of the Examination Committee at the Ruth and Bruce Rappaport Faculty of Medicine, Technion (Israel Institute of Science and Technology), Haifa. M. D. , specialist in internal medicine and lung diseases. Involved in all departmental teaching of medical students since 1975. Developed all existing medical cases of the VP System. Mr. Daniel Fatelevich Co-founder ► ► ► IT system developer with extensive experience in the field and a specialist in Data Base development. Vast experience as programmer since 1980. Among other projects, Daniel developed the first Argentinian data base in CD-Rom in 1991 and library system for PC in 1993. Mr. Fatelevich has been leading the development and implementation of the VP System since its inception. Page 14 Virtual Patient Ltd. Co-founder ► ► IT specialist with 40 years of experience, including academic and teaching background. Extensive experience in leading and managing IT development projects and development teams. Experience as a senior programmer and computing manager in leading companies such as Paz Oil Co. Ltd. , Israeli Oil Refineries and M. L. L. Systems Ltd. Adam has been leading the development and implementation of the VP System since its inception. Point of contact Ms. Hani Hoffman Business development Web: www. virtual–patient. com Email: mail@virtual-patient. com Mobile: +972 50 3001848 Confidential March 2015