Vi si M i x Simulation of Mixing

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Vi si M i x Simulation of Mixing Processes Visi. Mix Ltd, PO Box 45170, Jerusalem, 91450, Israel Tel: 972 - 5870123 Fax: 972 - 5870206 E-mail: info@visimix. com

Vi si M i x Simulation of Mixing Processes Presentation Contents: - The Customers - The Technology - ROI - Visi. Mix Products - Saving Examples

About Us Visi. Mix is a unique software enabling chemical engineers, process engineers and R&D personnel to visualize mixing processes via a simple, user friendly interface. Our products allow significant savings in time and costs by drastically reducing the need for trial-and-error. They have been successfully adopted by hundreds of companies.

Customers and Markets Our Customers

What Our Customers Say About Us From the Dow Chemicals Intranet Website “Visi. Mix: This is a highly accessible PC software for mixing calculations available from Visi. Mix Ltd. , an Israeli company. It is a rating calculation tool for both nonreactive and reactive mixing involving blending, solid suspension, gas dispersion, liquid-liquid dispersion, or heat transfer processes in stirred vessels. It calculates the important process parameters for single- and two-phase systems – power consumption, circulation rates, local concentrations of solutes and suspended particles, drop size, concentrations of reactants, etc … ” Dr. Victor Atiemo-Obeng Dow Chemicals Co.

What Our Customers Say About Us “We have been using Visi. Mix. We have found it an accurate tool. . . Based on our success with the product, our Japanese colleagues at Fuji Xerox have bought a copy for their work. ” Emily Moore, Xerox Research Center of Canada “I am very pleased in applying your software. ” L'Oreal, France

Customers and Markets Customer List 1. L'Oreal, France 2. BASF AG, Germany 3. Dow Chemical Company, USA 4. Searle (MONSANTO), USA 5. Lightnin, USA 6. LG Chemicals, S. Korea 7. Xerox , Canada & USA 8. The Gillette Co. , USA & UK 9. De Dietrich, France & USA 10. ENIChem, Italy 11. Eli Lilly & Company, USA 12. NIPPON, Japan 13. Novartis, USA 14. Millennium, USA 15. ICI, UK 16. Hercules, USA 17. Pfizer, USA&UK&Gr. 18. Mitsubishi Chemicals 19. Abbott Laboratories, USA 20. Glaxo. Wellcome, UK&Singapore 1. L'Oreal, France 2. Techmix S. r. o, Czesh Republic 3. BASF AG, Germany 4. BASF, Denmark 5. BP Chemicals - Wingles, France 6. Sanofi Recherche, France 7. Technimont, Italy 8. Nycomed Imaging, Norway 9. Hoesch & Sohne, Germany 10. DSM, The Netherlands 11. Searle (MONSANTO), USA 12. Lightnin, USA 13. Chevron, USA 14. Teva, Israel 15. Plantex, Israel 16. Bromine Compounds, Israel 17. ENSIC, France 18. LG Chemicals, Taejon-city, S. Korea 19. LG Tech, Yeochon-city, S. Korea 20. Lonza, Switzerland 21. Thai Plastic and Chemical Public Company, Thailand 22. Xerox Research Centre of Canada, Canada 23. Xerox, USA 24. The Gillette Co. , USA 25. Gillette, UK 26. Lecaros, Chile 27. SK Chemicals, S. Korea 28. Dow Chemical Company, USA 29. Monsanto, USA 30. Buchi AG, Switzerland 31. Agisys, Hungary 32. Samsung, S. Korea 33. Mervers, Holland 34. American Cyanamid Company, USA 35. Belinka Belles, d. o. o. , Slovenia 36. LG Chem. , ABS Division (S. Korea) 37. BFGoodrich Advanced Technology Group, US 38. PT MECO INOXPRIMA, Indonesia 39. Ion Exchange, India 40. IL JIN Eng. & Const. Ltd. , Korea 41. CSIR Ltd. , South Africa 42. PTI, Brazil 43. De Dietrich, France 44. De Dietrich, USA 45. Rhodia (Rhone Poulenc Group), Brazil 46. Inymassa, Spain 47. ENIChem, Italy 48. Satake, Japan 49. Chesebrough-Pond’s, USA 50. Unilever, Italy 51. Schering-Plough, USA 52. Ontec, Israel 53. Cytec, USA 54. Degussa, Germany 55. IHN Groningen BV, the Netherlands 56. PEAS BV, the Netherlands 57. Eli Lilly & Company, USA 58. BSL (Dow group), Germany 59. VMD PTE Ltd. , Singapore 60. Tecnicas Reunidas, Spain 61. NIPPON, Japan 62. Chr. Hansen, Denmark 63. Danisco, Denmark 64. Novartis, USA 65. SNECMA, France 66. Millennium, USA 67. Ucosan B. V. , Holland 68. Norde Veenendaal B. V. , Holland 69. Akzo Nobel, Germany 70. Astra Charnwood, UK 71. ICI, UK 72. Stork, Netherlands 73. Hercules, USA 74. Luigi Menestrina, Italy 75. Siersma Leidshendam, the Netherlands 76. Sara Lee, the Netherlands 77. Pfizer, USA 78. Pfizer, UK 79. Pfizer, Germany 80. Beiersdorf AG, Germany 81. Sintef Applied Chemistry, Norway 82. Chemitec OY, Finland 83. Makhteshim, Israel 84. Chemagis, Israel 85. Nitto Denco, Japan 86. 3 M, USA 87. Broom Chemie, the Netherlands 88. Atlas-Stord, Denmark 89. Canon, Japan 90. Mitsubishi Chemicals 91. Imation, USA 92. NIKKI, Japan 93. Fuji Xerox, Japan 94. Oxy Vynils 95. Scanlube, Sweden 96. Glaxo. Wellcome, Singapore 97. Glaxo. Smith. Kline, UK 98. Smith. Kline Beecham, USA 99. M&F Process Simulation, The Netherlands 100. Abbott Laboratories, USA 101. Air Products, USA 102. Gruppo Lepetit, Italy 103. Johnson Polymer, Holland 104. Dow Corning, USA 105. Pharmacia Biotech, Sweden 106. Panandiker Research & Development (P) Ltd. , India 107. Fujifilm, Japan 108. Katholieke Hogeschool Brugge-Oostende, Belgium 109. The Casali Institute, Israel 110. Noordelijke Hogeschool Leeuwarden, the Netherlands 111. Stettin University 112. Taiwan University 113. Ecole d'Electrochemie, France 114. Ecole Polytechnique, Canada 115. University of Western Ontario, Canada 116. University of Barcelona, Spain 117. Taejon National University, S. Korea 118. Otto von Guericke Universitat, Germany 119. Tsinghua University, China 120. VUOS, Czesh Republic 121. Universita di Roma, Italy 122. Hanyang University, S. Korea 123. Royal Institute of Technology, Sweden Total : 123 customers

De Dietrich - Example http: //www. ddpsinc. com/Mixing. Simulations. htm

De Dietrich - Example http: //www. ddpsinc. com/Visimix. htm

Simple and Effective - Interface Technology - Simulation of Mixing Processes

Simple and Effective - Background Technology - Simulation of Mixing Processes The First and the only tool in the Industry Reliable and accurate results Based on More Than 300 Man Years of R&D and Industry Experience Replacing Pilot Experiments Accelerated Time-to-Market process User Friendly and easily accessible

Simple and Effective Return On Investment (ROI) Per Year basis Benefits (The ICI Example) Product Cost $15, 000 Savings Per project - $20, 000 Per year - $150, 000 (5 -10 projects per year) Quality Time To Market

Visi. Mix Products Introduction Visi. Mix software: • Based on advanced scientific knowledge and practical expertise • User-friendly and easy to operate • Requires easily accessible initial data The latest Visi. Mix products are: • Visi. Mix 2 K 8 Turbulent • Visi. Mix 2 K 8 Laminar • Visi. Mix 2 K 8 Different Impellers • Visi. Xcel

Visi. Mix Products Visi. Mix Software Products • Visi. Mix 2 K 8 Turbulent – for low-viscosity liquids and multiphase systems. The program provides process parameters necessary for analysis, scaling-up and optimization of mixing tanks and reactors with all types of impellers Calculations of: ü Blending ü Suspension ü Dissolution ü Emulsification ü Gas dispersion ü Heat transfer ü Chemical reactions ü Mechanical stability of shafts

Visi. Mix Products Visi. Mix Software Products • Visi. Mix 2 K 8 Laminar - for highly viscous media ü ü Newtonian and non-Newtonian Macro-scale blending Micromixing in high-shear areas Heat transfer • pastes • creams • shampoos • liquid soaps • gels • ointments • paints: • coatings • slurries • polymer solutions

Visi. Mix Products Visi. Mix Software Products • Visi. Mix 2 K 8 Different Impellers – for combined mixing devices The program handles mixing devices consisting of any 2 – 5 impellers. Different distances between impellers Used in combination with Visi. Mix Turbulent. Provides parameters of hydrodynamics, turbulence and heat transfer. • Visi. Mix Visi. Xcel – automatic conversion of Visi. Mix output parameters into Excel spreadsheets. ü Integrating Visi. Mix report parameters in standard Excel worksheets ü Analyzing Visi. Mix results in Excel

Visi. Mix Orientation Visi. Mix Demonstration Tools The Visi. Mix Demonstration Tools: ü Visi. Mix Turbulent – Examples & User Guide ü Visi. Mix Laminar - Examples & User Guide ü Visi. Mix Different Impellers – Examples & User Guide ü Visi. Mix Turbulent SV – Trial & Education ü Visi. Mix Review of Mathematical Models

Saving Examples Finance Saving Examples (ROI) 1. Cooling A Paste 2. Paints 3. Suspension in a Batch Reactor 4. Scale up Methodology

Finance Saving Examples (ROI) Example Case Classic Solution Visimix Solution Saving Cooling of a Paste Batch Production Time Replacement of the whole mechanical system Input the existing mixing systems parameters to Visi. Mix software, implement small changes $125, 000 per year Paste and Coating Mixing several components to obtain high quality paint during scaleup process Increase the impeller speed and improve the heat removal in the tank. No successful results obtained Change agitator dimension for uniform mixing without overheating $40, 000 per year Suspensions in a batch reactor Plugging of the bottom valve of the reactor Replacement of the agitator Lower the impeller position $12, 000 saved on the cost of a new impeller and for all associated operational costs Scale up Methodology Implementation during the Scale studies Calculation after finishing the development stage Calculation during the development stage Decrease in the quantity of out of spec material in the launching and production steps.

Cooling a Paste

PAINTS PAINTS

Suspension in a batch reactor

Scale up optimization using simulation experiments. Scale Up Methodology (J. M. Berty. CEP, 1979)

Scale Up optimization using simulation experiments.

Scale Up optimization using simulation experiments. Financial aspects # produced lots until achieving to a stable process

Summary • Save per project • Save during development

Thank You Positive reaction from customers from all over the world confirms: - Visi. Mix is of tremendous help wherever mixing is involved. Thank you From the Visi. Mix Team

Thank you for your attention