VERIS by Electro-Diagnostic Imaging Inc Redwood City

VERIS ™ by Electro-Diagnostic Imaging, Inc. Redwood City, California, USA First in Multifocal Electrophysiology and its Future

The Multifocal ERG

120 scaled elements Monitor screen ~40° The Multifocal VEP Gold cup electrodes Amplifcation 100 k gain 3 -100 Hz Computer fast m-transform 120 focal VEPs 500 nv 200 ms

Traditional Visual Electrodiagnostic Testing EOG Full-field ERG ISCEV Standards + full control of Ganzfeld stimulation and data analysis for supplementary testing Pattern ERG Traditional VECP Fast quadrant VECP using m-sequence stimulation

VERIS™ Ganzfeld Stimulator Special Features • All solid state engineering • Continuous computer control of Flash intensity (max. > 100 cd • sec/m 2) Flash chromaticity Flash duration Background luminance (max. >1000 cd/m 2) Background chromaticity 3 Red Fixation LEDs for EOG recording • Integrated infrared eye camera Monitor electrode & fixation while recording All Ganzfeld recording uses fully automated protocols that can be customized with VERIS Science software

Complete VERIS™ system using the FMSIII (fundus monitoring stimulator) Ssolid State (RGB color) Ganzfeld Stimulator with IR Eye Camera FMS II Stimulator and Fundus/Eye Camera Wheelchair accessible stimulator System works with any laser or inkjet printer Software controlled amplifier system (up to 16 channels) Isolation Transformer

Monitoring the Patient’s Fixation (Essential for Multifocal Testing) Eye Camera Can monitor fixation stability Fundus Camera Monitors position of the stimulus array on the fundus

FMS III Stimulator with Eye and Fundus Monitoring during Stimulation Stimulated field ~ 500 standard Incorporates: • High resolution color microdisplay for stimulation • Eye camera for alignment • Fundus camera for fixation monitoring

$Complete VERIS™ system using 9” stimulator with integrated refractor/camera$

Complete VERIS™ system using 9” stimulator with integrated refractor/camera

$21” Ultra High Luminance Stimulator with Eye Camera/Refractor Stimulated field ~ 500 standard$

21” Ultra High Luminance Stimulator with Eye Camera/Refractor Stimulated field ~ 500 standard

Conventional and Multifocal stimulation of Retinal Preparation through Microscopes Attaches to camera port with C-mount Features: • • High resolution microdisplay (1280 x 1024) Fast Response time (<50 µs) RGB color High light intensity capability

Kernels v/s Responses and some New Developments in VERIS 6 The m-sequence technique provides a series of kernels. Most of us do not have an intuitive understanding of these mathematical constructs. However, from them we can easily predict the results of many experiments such as double and multi-flash tests from a single m-sequence stimulus series. This is illustrated in the following few slides that are derived from a single record of 54 seconds duration using m-sequence Ganzfeld flash stimulation. Ask for a Demo with VERIS!

Test: Test Kernel Series Ganzfeld standard flash Record length 54 s Base Inteval 20 ms First Order Kernel Second Order Third Order Forth Order Not all kernels used in the analysis are shown here

Test: Test Kernel Series Ganzfeld standard flash Record length 54 s Base Inteval 20 ms First Order Second Order Third Order Forth Order Not all kernels used in the analysis are shown here

Test: Test Kernel Series Ganzfeld standard flash Record length 54 s Base Inteval 20 ms First Order Second Order Third Order Fourth Order Not all kernels used in the analysis are shown here

Response Sequence Derived from the Kernel Series Ganzfeld standard flash Record length 54 s, Base Interval 20 ms Single Flash Response Double Flash Responses Interval 20 ms Interval 40 ms Interval 60 ms

Response Sequence Derived from the Kernel Series Ganzfeld standard flash Record length 54 s Base Interval 20 ms Single Flash Response Double Flash Responses Interval 20 ms Interval 40 ms Interval 60 ms

Response Sequence Derived from the Kernel Series Ganzfeld standard flash Record length 54 s Base Inteval 20 ms Single Flash Response Double Flash Responses Interval 20 ms Interval 40 ms Interval 60 ms

From the Same Short Record Single Flash (transient) Response Flicker Response

Kernels v/s Responses The same kernel synthesis can be performed on multifocal records. The following three slides were all derived from the same single 7 minute record from a normal subject. Ask for a Demo with VERIS!

First Order Kernel Isolated Focal Flash Response

Multifocal Flicker 37 Hz

Multifocal Flicker 75 Hz

The Optic Nervehead Component (ONHC) for Evaluating Ganglion Cell and Optic Nerve Function

Fig. 1 Feature contributed by the ONHC Optic nerve head Direct Response First Induced Component Second Induced Component Response Epoch Used in this Study

Normal Subject

The ONHC in Primary Open-Angle Glaucoma

hb. 01. 24. 02. mfofo. 100 hz. 600 os

120 scaled elements Monitorscreen ~40° The Multifocal VEP Gold cup electrodes Amplifcation 100 k gain 3 -100 Hz Computer fast m-transform 120 focal VEPs 500 nv 200 ms

Dartboard Pattern Stimulus for mf. VEP Recording with Various Numbers of Sectors

™ VERIS 6 Software Four Levels 1. BASIC • Simple mf. ERG 2. CLINIC • All Pre-programmed Tests 3. SCIENCE • CLINIC + full stimulation and analysis creation and editing capability 4. PRO • SCIENCE + advanced kernel synthesis

Apple OS X Platform • Exceptionally stable • VERIS data can be stored automatically to any local, network, or Internet-accessible storage device • Choice of open or password-protected file locking of data, analysis settings, and recording settings files • Easy creation of pdf copies of reports for electronic medical records or email communications without additional (3 rd party) software • Easy to learn and fun to use!

Real-time Internet support from EDI • Available to all VERIS users by appointment • Real-time monitoring and control of your VERIS system from our California office for training and troubleshooting at your location. • Fully encrypted with security controls and session transcripts to ensure privacy of medical information • Supplied through Motorola Corp. e. Care platform • Requires only fast Internet connection