Varicose Remodeling of Veins Is Suppressed by 3‐Hydroxy‐ 3‐Methylglutaryl Coenzyme A Reductase Inhibitors by Johannes Eschrich, Ralph Meyer, Hanna Kuk, Andreas H. Wagner, Thomas Noppeney, Sebastian Debus, Markus Hecker, and Thomas Korff J Am Heart Assoc Volume 5(2): e 002405 February 23, 2016 © 2016 Johannes Eschrich et al.
Statins inhibit stretch‐induced activation of AP‐ 1 in HUVSMCs. A, Nuclear extracts from HUVSMCs, stretched for 1 to 6 hours and/or treated or pretreated with 10 μmol/L AVS, RVS, or SVS, were exposed to 32 P‐labeled double‐stranded gel shift ODNs mi. . . Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
MCP 1 m. RNA expression in stretch‐stimulated HUVSMCs. m. RNA expression ratio of MCP 1 and RPL 32 (house‐keeping gene) was determined by real‐time polymerase chain reaction from samples of HUVSMCs exposed to biomechanical stretch for 6 hours (0. 5 Hz, 13. . . Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
AVS and RVS inhibit human VSMC proliferation. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
Atorvastatin and Rosuvastatin attenuate pressure‐induced phosphorylation of c‐Fos in venous wall cells. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
AVS counteracts pressure‐induced activation of venous wall cells. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
AVS and RVS attenuate the pressure‐induced decrease in myocardin abundance in veins. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
RVS lowers blood cholesterol levels in NMRI mice. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
Treatment with AVS or RVS blocks varicose‐like venous remodeling in the mouse auricle model. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
Treatment with SVS does not block varicose‐like venous remodeling in the mouse auricle model. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
Proliferation in an auricle vein on induction of venous hypertension. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
Statin treatment diminishes phosphorylation of c‐Fos of SMCs in human varicose veins. c‐Fos and p‐c‐Fos (activated) were detected by immunofluorescence analyses in cross‐sections of excised human varicose saphenous vein segments from patients chro. . . Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
Statin treatment diminishes SMC activation in human varicose veins. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
Statin treatment diminished smooth muscle cell activation in human varicose veins. Johannes Eschrich et al. J Am Heart Assoc 2016; 5: e 002405 © 2016 Johannes Eschrich et al.
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