VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEE CBER, FDA February 16 -17, 2005, Bethesda, MD Nancy COX, Ph. D. WHO COLLABORATING CENTER FOR SURVEILLANCE, EPIDEMIOLOGY AND CONTROL OF INFLUENZA Influenza Branch Division of Viral and Rickettsial Diseases National Center for Infectious Diseases Centers for Disease Control and Prevention Atlanta, GA 30333 Influenza Branch
Influenza A(H 5 N 1) December 2003 – February 2005 H 5 N 1 –outbreaks in birds , controlled and final report submitted to OIE H 5 N 1 –outbreaks in birds reported H 5 N 1 – outbreaks in birds and humans Influenza Branch
Human H 5 N 1 Cases, 2004 -2005 Country H 5 N 1 Cases Deaths Case Fatality Cambodia 1 1 100% Thailand 17 12 71% Vietnam 37 29 78% Total 55 42 76% Ø High case fatality regardless of age Ø Clinical symptoms similar to earlier cases, including lymphopenia Ø Diarrhea prominent in some cases ØSecond wave of infections in Aug 2004 -present ØThai family cluster; probable H-to-H transmission Influenza Branch
Antigenic Characterization of H 5 N 1 Influenza Viruses FERRET H 5 N 1 ANTISERA VIRUSES VN/1203/03 CK/KO/03 HK/213/03 HK/97 VN/1194/04 640 40 <10 VN/1203/04 640 40 20 <10 1280 80 ND <10 20 80 20 40 160 320 5120 320 80 640 320 TH/353/04 CK/KOR/ES/03 HK/213/03 HK/97 Influenza Branch
Conclusions Ø Ø Ø Ø Avian influenza viruses can pose a major risk to global public health (H 5 N 1, H 7 N 7, H 9 N 2, etc. ) Early detection H-2 -H transmission of novel influenza viruses is essential 2003/05 Asian viruses are heterogeneous in AV susceptibility and pathogenicity; more lethal in mammals than 1997 strains Ongoing vaccine development, antiviral stockpiling and pandemic preparedness Surveillance in animals (birds, swine and other susceptible hosts) is critical Research agenda needed to enhance our understanding of the genesis of pandemic influenza viruses Global recognition of need for better communication between human and veterinary health authorities Influenza Branch
Influenza: An Emerging Disease that Rolls On Influenza Branch
Influenza Virus Isolates Characterized by CDC and Other WHO Collaborating Centers and Laboratories * (October 2004 – February 2005) North America Europe Asia A(H 1 N 1) 2 115 74 A(H 3 N 2) 616 402 212 B/Yamagata 98 62 B/Victoria 18 Total 734 Cent/So America Africa, Oceania Total (%) 2 193 (8%) 4 458 1692 (75%) 30 1 112 303 (14%) 28 16 3 9 74 (3%) 607 332 8 581 2262 Preliminary Data 02/14/2005 * Data based on cumulative influenza virus isolates antigenic characterization data provided by WHO Collaborating Centers in Atlanta, London, Melbourne, Tokyo, reports from European Influenza Surveillance Scheme and National Influenza Center, Canada Influenza Branch
Influenza A(H 1 N 1) Influenza Branch
HEMAGGLUTINATION INHIBITION REACTIONS OF INFLUENZA H 1 VIRUSES REFERENCE FERRET ANTISERA REFERENCE ANTIGENS 1 2 3 4 5 6 A/BEIJING/262/95 A/N. CALEDONIA/20/99 * A/FUJIAN/156/2000 A/NEIMENGGU/52/2002 A/CHILE/8885/2002 A/PERU/3135/2003 BJ/262 NC/20 640 160 80 40 40 160 640 640 320 40 160 320 160 80 320 320 160 320 10 320 320 160 320 160 160 160 1280 1280 1280 640 640 640 1280 1280 1280 640 640 320 640 1280 1280 1280 640 640 640 1280 640 320 640 640 320 320 320 160 320 640 Date collected Passage 40 160 80 40 20 640 01/09/95 06/09/99 08/25/00 01/25/02 07/03/02 04/09/03 E 3/E 3 E 4/E 2 E 2/E 4 E 1/E 4 X/C 3 320 640 640 320 320 320 160 320 160 320 12/20/04 12/09/04 09/18/04 09/20/04 09/23/04 09/27/04 10/04/04 09/20/04 10/04/04 09/23/04 09/24/04 08/31/04 10/04/04 03/31/04 06/11/04 04/19/04 07/10/04 09/25/04 10/08/04 10/25/04 X 1/C 1 X 2/C 1 C 1/C 1 C 1/C 1 C 1/C 1 E 3/E 1 C 1/C 1 E 4/E 1 E 2/E 1 C 2/C 1 FUJ/156 NEI/52 CI/8885 PE/3135 TEST ANTIGENS 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 A/FLORIDA/04/2004 * A/FLORIDA/03/2004 A/PRACHINBURI/1749/2004 A/BANGKOK/1757/2004 A/PRACHINBURI/1817/2004 A/BANGKOK/1876/2004 A/SUPHANBURI/2131/2004 A/BANGKOK/1752/2004 A/SUPHANBURI/2130/2004 A/BANGKOK/1822/2004 A/RATCHABURI/1847/2004 A/BANGKOK/1544/2004 * A/SUPHANBURI/2129/2004 A/SAKAEW/2132/2004 A/SINGAPORE/14/2004 A/N. CALEDONIA/9/2004 A/N. CALEDONIA/3/2004 A/MALAYSIA/1513/2004 A/HONG KONG/4555/2004 A/HONG KONG/4580/2004 A/HONG KONG/4596/2004 * Serology antigens Influenza Branch
Influenza A(H 1) Isolates Characterized by CDC U. S. A. North America Europe Asia Cent/So America Africa, Australia, New Zealand Total (%) 3 2 1 16 1 2 25 (9%) October 2003 – March 2004 A/N. Caledonia/20/99 - like A/N. Caledon. /20/99 (low) 2 1 3 (11%) Total 28 2 43 (98%) April 2004 –September 2004 A/N. Caledonia/20/99 - like 1 4 A/N. Caledon. /20/99 (low) 36 1 1 (2%) 44 October 2004 – January 2005 A/N. Caledonia/20/99 - like 2 12 14(100%) A/N. Caledon. /20/99 (low) 14 Total 5 3 7 65 2 4 86 Influenza Branch
Evolutionary Relationships Among Influenza A(H 1) HA Genes Hong Kong/2637/04 nimr. Hong Kong/2675/04 Taiwan/1559/04 0 5 nucleotides niid. Taiwan/1559/04 aus. Christ Church/106/04 (LR) Low reactor in HI aus. Philippines/987/04 # - Egg Isolate Taiwan/1571/04 aus. Philippines/936/04 R 192 K * Serology Antigen niid. Okinawa/42/04 aus. Ayathaya/2111/04 Ayathaya/1720/04 Date Collected Bangkok/1544/04#* Y 101 H aus. Taiwan/1559/04 Jan-Feb-Mar aus. Bangkok/1940/04 Apr-May-Jun Canada/591/04 Jul-Aug-Sep Singapore/11/2004 Oct-Nov-Dec T 90 K, R 212 K Massachusetts/1/04 Singapore/5/04 T 269 N aus. New Caledonia/3/04# aus. New Caledonia/4/04# R 149 K aus. New Caledonia/9/04# Indonesia/5840/04 Indonesia/5841/04 Singapore/14/04#* Q 285 H aus. Singapore/14/04#* Florida/3/04 nimr. Ireland/15680/04 Florida/4/04* nimr. Netherlands/128/04* tw. Taiwan/1574/04 tw. Taiwan/1573/04 niid. Okayama/53/04 niid. Nagano/1328/03 aus. Prachinburi/1686/04 Sakaew/2132/04 nimr. Ireland/9728/04 Hong Kong/4596/04 Prachinburi/1817/04 Nonthaburi/1739/04 V 317 A aus. Malaysia/1513/04# V 317 A nimr. Lyon/Chu 28824/04 Y 256 F nimr. Lyon/Gi 346/04 F 256 Y Saudi Arabia/2526/04 A 317 V Suphanburi/2129/04 Ratchaburi/1847/04 New Caledonia/20/99#* V 169 A, N 190 D, W 255 R Influenza Branch
Evolutionary Relationships Among Influenza N 1 NA Genes 0 Scale 3 Nucleotides *Serology antigen (LR) Low reaction to HI # Egg isolate A/Argentina/6/2003 A/New Caledonia/20/99 A/Suphanburi/2129/2004 A/Hong Kong/4555/2004 A/Bangkok/1724/2004 A/Bangkok/1752/2004 A/Bangkok/406/2004# A/Bangkok/1876/2004 A/Bangkok/1507/2004# A/Bangkok/1759/2004 A/Bangkok/1498/2004# A/Bangkok/1757/2004 A/Prachinburi/1817/2004 A/Prachinburi/1749/2004 A/Bangkok/1822/2004 A/Bangkok/1467/2004# A/Nonthaburi/1738/2004 A/Bangkok/1410/2004# A/Nonthaburi/1739/2004 A/Florida/03/2004 E 332 K A/Florida/04/2004* N 450 D A/Suphanburi/2130/2004 A/Suphanburi/2131/2004 A/Bangkok/1755/2004 A/Hong Kong/4580/2004 A/Nagano/1328/2003 A/Argentina/678/2003 A/New Mexico/7/2003 aus-A/Malaysia/1003/2003 A/Malaysia/1513/2004# A/Mexico/268/2003 A/Romania/955/2003 nimr-A/Moscow/7/2003 aus-A/Chrischur/1/2003 nimr-A/Israel/2/2003 A/Michigan/5/2003 A/Michigan/4/2003 A/Michigan/6/2003 A/Michigan/1/2003 nimr-A/Barcelona/7891 v 31/2003 A/Peru/2223/2003 A/Peru/3192/2003 A/Peru/3135/2003 A/Minnesota/18/2003 A/Gansu/185/2003 aus-A/Darwin/1/2003 A/New Caledonia/3/2004# V 234 M A/Singapore/14/2004 A/Sakaew/2132/2004 A/Singapore/14/2004#* A/Singapore/23/2004 A/Ayatthaya/2111/2004 A/Bangkok/1544/2004#* A/Bangkok/1699/2004 E 214 G, R 222 Q A/Bangkok/1741/2004 D 382 N A/Bangkok/1742/2004 A/Hong Kong/2637/2004 A/Ratchaburi/1847/2004 A/Bangkok/1468/2004# A/Ayutthaya/1720/2004 A/Guangzhou/78/2003 A/Sichuan/646/2002 Influenza Branch
HI Antibody Response to 2004 -2005 Vaccine (adults) % w/HI titer >40 Sera N 30 Japan 30 30 30 25 USA 25 25 25 Antigen A/New Caledonia/20/99 A/Bangkok/1544/2004 A/Florida/04/2004 A/Netherlands/128/2004 % Rise 23 17 17 27 32 32 24 24 Pre Post GMT Vaccine 21 26 27 27 19 23 24 26 44 54 54 59 54 57 53 66 43 53 53 57 44 40 48 52 67 77 73 77 76 76 80 80 Influenza Branch
H 1 Summary: October 2004 to February 2005 Ø Relatively few H 1 viruses have been detected worldwide Ø The majority of H 1 N 1 viruses were closely related antigenically to the A/New Caledonia/20/99 vaccine strain and no significant variants of H 1 N 1 viruses were detected Ø No H 1 N 2 viruses were detected Ø N 1 neuraminidase genes of recent H 1 viruses were similar to those of viruses isolated prior to October 2004 Influenza Branch
Influenza A(H 3 N 2) Influenza Branch
HEMAGGLUTINATION INHIBITION REACTIONS OF INFLUENZA H 3 VIRUSES STRAIN DESIGNATION REFERENCE ANTIGENS 1 2 3 4 5 A/WYOMING/03/2003 X-147 * A/WELLINGTON/01/2004 * A/NORTH DAKOTA/01/2004 A/CALIFORNIA/07/2004 * A/SINGAPORE/37/2004 REFERENCE FERRET ANTISERA Date collected Passage WY/3 WEL/01 ND/01 CA/7 SN/37 640 160 80 320 160 80 160 320 640 160 320 320 640 40 320 160 640 02/13/03 01/26/04 10/20/04 09/16/04 6/7/2004 X/E 1 E 3/E 2 Spf. CK 1 E 4 Spf. CK 1 E 3 E 4/E 1 320 320 160 160 80 80 40 80 80 160 80 320 160 160 80 40 80 40 40 80 160 80 20 40 160 20 640 1280 320 640 320 320 320 160 320 640 320 80 160 160 1280 640 320 320 640 160 320 160 160 160 320 640 320 160 1280 160 640 160 320 160 80 160 160 80 40 80 80 640 320 80 40 80 nd 40 11/27/04 12/28/04 01/06/05 11/29/04 11/09/04 01/05/05 01/03/05 12/29/04 01/05/05 12/12/04 11/18/04 12/27/04 11/22/04 01/05/05 01/07/05 01/05/05 01/06/05 11/16/04 11/03/04 12/01/04 01/05/05 11/22/04 12/29/04 11/09/04 09/15/04 Spf. C 1 KE 3 X 2/C 1 M 1/C 1 Spf. CK 3 E 3 Spf. CK 2 E 4 X 1/C 1 M 1/C 1 X/C 1 Spf. CK 2 E 2 X/C 1 Spf. CK 3 E 2 C 1/C 1 M 2/C 1 M 1/C 1 X 1/C 1 E 5/E 1 C 1/C 1 X/C 1 C 2/C 1 X/C 1 C 1/C 2 C 2/C 1 TEST ANTIGENS 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 A/KENTUCKY/6 e/2004 A/NEW YORK/57/2004 A/VIRGINIA/02/2005 A/WISCONSIN/21 e/2004 A/NEW YORK/39 e/2004 A/NEW YORK/02/2005 A/NEW YORK/03/2005 A/TEXAS/12/2004 A/MASSACHUSETTS/01/2005 A/ALASKA/16/2004 A/NEW YORK/55 e/2004 A/N. HAMPSHIRE/04/2004 A/WISCONSIN/16 e/2004 A/WEST VIRGINIA/01/2005 A/VIRGINIA/03/2005 A/ARIZONA/03/2005 A/GEORGIA/01/2005 A/CANADA/707/2004 A/VICTORIA/523/2004 A/MADRID/RR 1734/2004 A/UNITED KINGDOM/305/2005 A/NORWAY/1103/2004 A/IRAQ/01/2004 A/SINGAPORE/68/2004 A/HONG KONG/4465/2004 * Serology antigens Influenza Branch
HEMAGGLUTINATION INHIBITION REACTIONS OF INFLUENZA H 3 VIRUSES (guinea pig red blood cells) Influenza Branch
Influenza A(H 3 N 2) Isolates Characterized by CDC Influenza Branch
Evolutionary Relationships Among Influenza A(H 3) HA Genes Washington/1/2004 # LR NIMR-Lisbon/4/2004 California/7/2004 # LR * Alaska/3/2004 # LR Singapore/36/2004 # LR * Singapore/37/2004 # LR Aus-Victoria/512/2004 # Maryland/2/2004 LR New York/39/2004 # New York/55/2004 K 145 N New York/40/2004 # Nepal/1646/2004 LR NIMR-Latvia/15743/2004 Aus-Malaysia/25/2004 LR NIID-Kobe/189/2004 N 278 K Wisconsin/16/2004 # S 227 P Wisconsin/19/2004 # North Dakota/1/2004 # LR Georgia/1/2004 LR Texas/6/2004 LR Aus-Wellington/1/2004 # * El Salvador/43/2004 LR Japan/120/2004 # Wisconsin/21/2004 # K 145 N Guangdong/596/2004 LR K 326 T Canada/578/2004 LR * Hong Kong/2874/2004 LR Hunan/L 200 -3/2004 * Tennessee/6/2004 LR * NIID-Mie/1/2005 Ningbo/1032/2004 * Aus-Victoria/500/2004 # NIID-Sendai/67/2004 Hong Kong/1186/2003 # LR Fujian/411/2002 Korea/770/2002 Texas/40/2003 # Wyoming/3/2003 (X-147) # * Peru/1296/2004 LR 22 D 188 N LR - Low reactor to A/Wyoming/3/2003 Vaccine Strain # - egg isolate * - Reference antigen 0. 01 Panama/2007/99 # Influenza Branch
Evolutionary Relationships Among Influenza N 2 NA Genes 0 Scale 7 Nucleotides *Serology antigen (LR) Low reactor in HI # egg isolate N 92 D, EI 99 K Q 432 E S 18 A, F 23 L, I 30 V, Y 40 H, F 42 C V 143 G, K 172 R, V 216 G, T 265 I, I 307 V, N 385 K, D 399 E, L 437 W Panama/2007/99 Sydney/5/97 Ningbo/982/2004 Ningbo/1043/2004 Ningbo/1042/2004 Ningbo/1032/2004(LR)* Ningbo/1114/2004 Ningbo/1018/2004 Hong Kong/2874/2004 K 221 E Hong. Kong/2976/2004 I 392 T Hong. Kong/2982/2004 Hong Kong/2874/2004 Ningbo/1119/2004 Hunan/L 200 -3/2004(LR)* Ningbo/1049/2004 Tennessee/6/2004(LR)* N. Dakota/01/2004# nimr-Lisbon/3/2004 New. York/55/2004# nimr-Baleares/720/2004 nimr-Ireland/9195/2004 Texas/6/2004 Ningbo/997/2004 Ningbo/1001/2004 New. York/40/2004# Washington/1/2004 California/7/2004(LR)#* Wellington/1/2004(LR)#* Singapore/15/2004 New. Caledonia/7/2004# Argentina/126/2004 Brazil/1759/2004 nimr-Reunion/581/2004 Hunan/L 201 -2/2004 Japan/120/2004# Singapore/21/2004 Singapore/36/2004(LR)#* Nepal/1646/2004 Korea/770/2002 Wyoming/3 e/2003#* Fujian/411/2002 nihj-Nagasaki/52/2003 Canada/578/2004(LR)* Ningbo/1005/2004 Wuhan/269/2004 French. Guyana/12/2004 Uruguay/3173/2004 Peru/1296/2004 Victoria/505/2004# Influenza Branch
H 3 Summary: October 2004 to February 2005 Ø Influenza A (H 3 N 2) viruses circulated in many countries in the Americas, Asia, Europe and Oceania. Ø In HI tests, A(H 3 N 2) viruses were antigenically heterogeneous. Viruses isolated early in the season were often more closely related to A/Fujian/411/02 and A/Wyoming/3/03. Ø An increasing proportion of recent isolates were antigenically distinguishable from the A/Wyoming/3/03 and A/Wellington/1/04 vaccine strains and were most closely related to the A/California/7/04 reference virus. Ø Sequence analysis of N 2 neuraminidase genes of recent H 3 N 2 viruses indicates that NAs of recent viruses were genetically distinguishable from that of the Wyoming/3/03 virus (N 93 D, E 199 K, Q 432 E) but were similar to the NAs of A/Wellington/1/04 and A/California/7/04. Influenza Branch
Influenza Branch
HEMAGGLUTINATION INHIBITION REACTIONS OF INFLUENZA B VIRUSES Influenza Branch
Influenza B Isolates Characterized by CDC Influenza Branch
Evolutionary Relationships Among Influenza B/Yamagata HA Genes LR - Low reactor to B/Shanghai/361/2002 Vaccine Strain # - egg isolate * - Reference antigen 0. 01 H 40 Y L 131 P North Carolina/5/2004 LR New Jersey/1/2005 LR NIMR-Madrid/g 1695/2004 Hawaii/18/2004 # LR Hawaii/19/2004 # LR Egypt/2040/2004 NIMR-Norway/1102/2004 NIID-Yokohama/5/2004 Aus-Victoria/501/2004 # Aus-Brisbane/5/2004 # N 123 S M 252 I California/3/2004 LR Colorado/4/2004 # LR * Massachusetts/3/2004 Saint Lucia/1689/2004 LR Washington/2/2004 Peru/1322/2004 LR Pennsylvania/4/2004 LR Florida/7/2004 # LR * Canada/580/2004 V 252 M NIID-Hyogo/6/2004 Argentina/584/2004 Concepcion/8881/2004 # Montana/1/2004 # LR Aus-Christchurch/27/2004 # Aus-Christchurch/33/2004 # Ulan-Ude/6/2003 # Fujian/437/2004 # LR Wuhan/281/2004 LR I 180 V Aus-Victoria/508/2004 # Jilin/20/2003 # Jiangsu/10/2003 # * K 129 N Shandong/22/2003 # D 233 A G 256 R Hong Kong/307/2004 Chanthaburi/218/2003 Aus-Brisbane/4/2004 # NIID-Shizuoka/144/2004 # Shanghai/361/2002 # Harbin/7/94 # Sichuan/379/99 # Influenza Branch
Evolutionary Relationships Among Influenza B/Victoria HA Genes Hawaii/20/2004 # LR Nevada/1/2005 LR Washington/1/2004 Hawaii/33/2004 # Hawaii/32/2004 # K 299 R Hawaii/31/2004 # Hawaii/13/2004 # * Aus-Phitsanulok/2053/2004 * A 217 S LR - Low reactor to Aus-Surin/1597/2004 B/Hong Kong/330/2001 Aus-Perth/33/2004 Vaccine Strain Aus-Perth/12/2004 # - egg isolate Kyonggi/501/2004 LR * - Reference antigen K 80 E Brazil/1921/2004 LR New York/9/2004 Saint Lucia/2185/2004 LR 0. 01 Florida/1/2004 NIID-Sichuan/12/2003 # Taiwan/1558/2004 Talcahuano/6830/2004 # LR Wulumuqi/26/2004 # Hong Kong/318/2004 LR K 48 E Aus-Malaysia/2276/2004 K 80 R Hong Kong/312/2004 LR K 129 N Hong Kong/310/2004 LR Aus-Malaysia/20/2004 NIMR-Israel/12/2004 Paraguay/636/2003 LR Aus-Brisbane/32/2002 # Kazakhstan/222/2004 I 121 T NIID-Akita/9/2003 # NIMR-Madagascar/72134/2004 Shanghai/47/2003 # Beijing/243/97 # Shandong/7/97 # Fujian/203/2003 # K 129 E H 116 R NIID-Longyan/11/2003 # I 121 N Hong Kong/1434/2002 # D 164 E Hong Kong/330/2001 # Taiwan/217/97 Influenza Branch
Evolutionary Relationships Among Influenza B NA Genes Shd/Sic Reassortants Taiwan/1547/2004 Jiangsu/10/2003#* Jilin/20/2003 nihj-Shizuoka/2/2004 Shandong/22/2003# Fujian/437/2004# Fujian/393/04# Hong. Kong/64/2004 Fujian/430/2004(LR)* Shanghai/361/2002 Shizuoka/58/2004# nihj-shizuoka/58/2004 0 Scale 7 Sichuan/379/99 aus-Brisbane/32/2002 nucleotides Madagascar/72134/2004 Paraguyy/6362003 *Serology antigen T 42 P, E 148 G, S 198 N Wulumuqi/26/2004 (LR) Low reaction in HI I 248 V, N 342 D, K 373 E Talcahuano/6830/2004# Peru/658/2004 T 389 A # egg isolate Phitsanulok/2053/2004(LR)* vaccine Okinawa/1/2004 Hawaii/10/2004 K 125 N, S 397 I Hawaii/09/2004# D 463 N Hawaii/20/2004# Hawai/13/2004(LR)#* Ulan. Ude/6/2003 Brazil/658/2004 Florida/7/2004(LR)#* Concepcion/8881/2004# Canada/508/2004 Victoria/509/2004# T 42 Q, T 49 I, K 186 R Christchurch/33/2004# N 219 K, N 235 D, S 244 P Victoria/50/2004 D 329 N, N 324 D, D 392 E Oslo/586/2004 E 436 T Brisbane/05/2004# nimr-Norway/110 -2/2004 Massachusetts/3/2004 New. York/17/2004 Colorado/03/2004# Colorado/05/2004# Colorado/4/2004#* Harbin/7/94 Yamagata/16/88 Victoria/2/87 Shandong/7/97 Hong. Kong/330/2001 Singapore/222/79 Influenza Branch
B Summary: October 2004 to February 2005 Ø Influenza B viruses continued to circulate in many countries Ø The majority of analyzed B viruses belonged to the B/Yamagata/16/88 lineage and were closely related antigenically to the B/Shanghai/361/2002 vaccine strain Ø Most B/Victoria/2/87 lineage viruses analyzed were reassortants, bearing a B/Hong Kong/330/2001 -like HA gene and a B/Sichuan/379/99 -like NA gene. Ø B/Victoria/2/87 lineage viruses were antigenically distinguishable from B/Hong Kong/330/2001, the previous vaccine strain from this lineage Influenza Branch
Influenza Virus Isolates Characterized by CDC and Other WHO Collaborating Centers and Laboratories * (October 2004 – February 2005) North America Europe Asia A(H 1 N 1) 2 115 74 A(H 3 N 2) 616 402 212 B/Yamagata 98 62 B/Victoria 18 Total 734 Cent/So America Africa, Oceania Total (%) 2 193 (8%) 4 458 1692 (75%) 30 1 112 303 (14%) 28 16 3 9 74 (3%) 607 332 8 581 2262 Preliminary Data 02/14/2005 * Data based on cumulative influenza virus isolates antigenic characterization data provided by WHO Collaborating Centers in Atlanta, London, Melbourne, Tokyo, reports from European Influenza Surveillance Scheme and National Influenza Center, Canada Influenza Branch
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