University of Cincinnati West Campus Instrumentation Facilities Bill Connick Professor of Chemistry 556 -0148 bill. Connick@uc. edu
Mass Spectrometry Facility • Thermo Finnigan LTQ-FTMS: Used for Accurate mass, LC-MS for general and biological compounds (Electrospray). • Micromass Q-TOF 2: Utilized for low molecular weight organic compounds (Electrospray). • GCT Micromass GC-MS: High resolution, accurate mass system with NIST Search Library capability (GC). • Agilent 5977 A MSD/7890 B GC System: Equipped with NIST Compound Search Library for unknowns identification. Training is provided for self sample runs to users. • Bruker Bi. Flex-III MALDI- MS: Used for peptides, intact proteins, synthetic polymers, oligos and high molecular weight organic molecules. For rates and additional information: http: //www. artsci. uc. edu/departments/chemistry/core-facilities/massspectometry-facility. html Contact: Larry Sallans, Ph. D (513) 556 -1575 larry. sallans@uc. edu Stephen Macha, Ph. D (513) 556 -1575 stephen. macha@uc. edu
Plasma Spectrochemical Analysis and Metallomics Center This facility specializes in the analysis of complex samples for elemental quantification, and chemical speciation. From biological samples to industrial materials down to parts per trillion for most common elements. • 2 x Agilent 7500 ce ICP-MS- Second generation octopole collision reaction system. • Agilent 8800 x ICP-MS-MS- Triple quad ICP-MS with 3 rd generation collision reaction cell, organic kit and auto sampler. • Agilent 6890 GC with transfer line to connect to the 8800 ICP-MS-MS- For analysis of volatile molecules, like pesticides, with compound-independent-calibration elemental capabilities. • CEM Explorer Microwave Digestion System- 10 or 35 ml vessels for digestion of 0. 01 to 0. 3 g of samples at 300 PSI and up to 200 o. C. • 4 x Agilent 1100 HPLC systems- With DAD and FLD detectors, with direct connection to the ICP-MS systems for speciation analysis. • Agilent 1200 nano. HPLC coupled to Agilent 6300 nano. Chip-ESI-IT-MS- Microfluidic nano-HPLC-MS-MS for analysis of peptides. • Millrock Benchtop Freeze Dryer- To lyophilize samples, to dry and concentrate under mild conditions. Contact: Prof. Julio A. Landero (513) 556 -4837 Landerjo@ucmail. uc. edu
Environmental Analysis Service Center (EASC) This facility supports the application of instrumental and bioanalytical techniques in the field of different engineering disciplines. It is equipped with state-of-the-art instrumentation with emphasis on high-resolution mass spectrometry and DNA sequencing. • Agilent 7700 x ICP-MS - 3 rd generation octopole reaction system with GC or LC. • Agilent 7890 A GC-7000 - quadrupole MS/MS for volatile and semivolatile compounds at the ppt level even when extracted from complex matrices. • Agilent 1290 LC-6540 Q-TOF - femtogram-levels that corresponds to high-resolution LC/MS instruments. Sub ppm mass accuracy from m/z 20 -10, 000. • Agilent 1200 LC-6410 - triple quad with electrospray ionization allowing for detection of polar compounds in water samples at the ng per liter concentrations without derivatization. • Ion Personal Genome Machine – DNA sequencer with Ion Torrent semiconductor chip technology as well as natural biochemistry. • vario MACRO cube - elemental analyzer capable of simultaneous CHNS determination. Contact: Dr. Zhiqiang (Mark) Wang EASC Director zhiqiang. wang@uc. edu (513)556 -4171 For rates and additional information: http: //ceas. uc. edu/bcee/Research_Centers/EASC/Lab_In strumentation. html
The ERC Clean Room & OCMI The ERC Clean Room is an 8000 square foot facility including areas of class 10, 1000, and 10, 000 located on the 300 level of the Engineering Research Center. It includes tools for photolithography, deposition, etching, oxidation, and characterization. The Ohio Center for Microfluidic Innovation (OCMI) is used for developing products that can be applied to biomedical, electronics, and sensor industries. The center includes equipment to take microfluidic devices from concept to pilot fabrication, located on the 900 level of Rhodes Hall. Access: Users must request access, complete web-based EH&S compliance training, and watch the clean room safety video. A tour of the facilities is given with an emphasis on safety. Addition training is required to use most of the equipment in the laboratories. For additional information on these extensively equipped facilities: - http: //ceas. uc. edu/cleanroom/Home. html - http: //ceas. uc. edu/ocmi. html Contact: Ron Flenniken Microelectronics Engineer (513) 556 - 4796 flennirg@ucmail. uc. edu Jeff Simkins Microelectronics Engineer simkinjr@ucmail. uc. edu (513) 556 - 4775
The ERC Clean Room & OCMI Capabilities • • • • Photolithography processing of small pieces up to 150 mm substrates Nano-imprinting over 150 mm substrates Multi-layer metal deposition up to six different metals Deposition of metal alloys and dielectrics with available substrate heating and biasing Conformal polymer coatings. High aspect ratio sub-micrometer etching Nanoscale morphology by atomic force microscopy Contact and non-contact 3 D surface metrology Optical interferometry for film thickness measurements Five-axis micro-milling of metal and plastic substrates Injection molding, hot embossing, and thermal bonding of plastics and composites Contact angle and surface tension analysis Measure particle flows in a microfluidic devices For additional information on these extensively equipped facilities: - http: //ceas. uc. edu/cleanroom/Home. html - http: //ceas. uc. edu/ocmi. html Contact: Ron Flenniken Microelectronics Engineer (513) 556 - 4796 flennirg@ucmail. uc. edu Jeff Simkins Microelectronics Engineer simkinjr@ucmail. uc. edu (513) 556 - 4775
Advanced Materials Characterization Center Scanning Electron Microscopy • FEI XL-30 Environmental SEM • Hitachi S-3400 N • FEI SCIOS Dual-Beam SEM/FIB • Lithography/Elemental Analysis/EBSD Transmission Electron Microscopy • CM-20 200 Kv La. B 6 • Elemental Analysis AFM • Dimension D-3100 • Wet-Cell • Contact/Tapping X-ray Diffraction • Panalytical XRPD • Panalytical X’Pert Pro • STOE Stadi-P (Transmission) Contact: Melodie Fickenscher, Ph. D 513 -556 -3220 fickenm@uc. edu For additional information: http: //amcc. uc. edu
Chemical Sensors & Biosensors Instrumentation Facility • Raman Microscope (Renishaw In. Via): Laser lines: 785 nm, 514 nm, 488 nm, 457 nm, 442 nm • FT-IR Spectrometer and Microscope (Nicolet 6700) • Multiplate Reader (Bio. Tek, Synergy 4) • UV/Vis (Cary 50) & Fluorescence (Cary Eclipse) • Digital Light Microscope (Keyence, VHX-1000 E) • Scanning Probe Microscope (Veeco): AFM, STM, EFM, MFM • Electron Microscope (FEI XL-30 ESEM) • Variable Angle Spectroscopic Ellipsometer (VASE) • Isothermal Titration Calorimeter (VP-ITC, Micro. Cal) • Simultaneous TGA and DSC (NETZSCH STA 409 PC) Contact: Necati Kaval, Ph. D (513) 556 -9201 kavaln@ucmail. uc. edu For additional information: http: //www. artsci. uc. edu/departments/chemistry/corefacilities/chemical-sensors---biosensors. html
X-ray Crystallography Facility • Bruker SMART APEX-II CCD Diffractometer System with low temperature capability for in-house 3 -dimensional structural analysis for single crystal chemical crystallography applications • Synchrotron radiation access through the SCr. ALS and SCr. APS projects at ALS (LBNL) and APS (ANL) • Olympus Stereomicroscopes with video & polarizing capability Contact: Jeanette Krause, Ph. D (513) 556 -9226 jeanette. krause@uc. edu For additional information: http: //www. artsci. uc. edu/departments/chemistry/corefacilities/x-ray-crystallography. html
NMR Facility • Bruker DMX 500 MHz: with GRASP capabilities • z-grad 1 H/13 C/15 N TXI probe: 3 D & 4 D protein NMR; 2 D 1 H-1 H, 1 H-13 C and 1 H-15 N spectra • z-grad BBI probe: direct 1 D 1 H, 15 N to 31 P NMR; 2 D 1 H-1 H & 1 H-X spectra (X: 15 N to 31 P) • Bruker AV 400 MHz with GRASP capabilities; fully automatic + autosampler • z-grad BBFO ATM probe: direct 1 D 1 H, 15 N to 31 P & 19 F NMR • 2 D 1 H-1 H and 1 H-X spectra (X: 15 N to 31 P and 19 F) • Bruker AMX 400 MHz: wide bore with solid-state capabilities • MAS accessory: MAS and CP-MAS 15 N - 31 P NMR in solids • solution BBI probe: direct 1 D 1 H, 15 N to 31 P & 19 F NMR in solution Contact: Keyang Ding, Ph. D (513) 556 -9201 dingkg@ucmail. uc. edu For additional information: http: //www. artsci. uc. edu/departments/chemistry/corefacilities/nuclear-magnetic-resonance-facility. html
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