U S HIV AIDS Therapies Markets Antiretroviral Drugs from

U. S. HIV/AIDS Therapies Markets Antiretroviral Drugs from Existing and Novel Categories Offer Major Growth Opportunities “Antiretroviral (ARV) drugs that prevent HIV replication are always recommended in combinations guided by the principles of highly active antiretroviral therapy (HAART), which seeks to reduce resistance, adverse reactions, and pill burdens, while improving efficacy. ” Pharmaceutical Biotech Analyst Team Frost & Sullivan © Copyright 2002 Frost & Sullivan. All Rights Reserved.

Key Features Frost & Sullivan provides: • Detailed insights into recent developments and trends • Drivers, restraints, challenges, and strategic recommendations • Analyst insights on ‘hot topics’ and emerging applications in the market • Market sizing and competitive analysis • Market forecasts and opportunity analysis • Quarterly assessments • End user analysis within each report © Copyright 2002 Frost & Sullivan. All Rights Reserved.

What We Offer • Coverage: The United States • Proven methodology encompassing extensive primary and secondary data and research • Focused information and strategies that cover business and technology issues • Credible data and analysis highlighting industry dynamics • Winning strategies to help you create precise business plans © Copyright 2002 Frost & Sullivan. All Rights Reserved.

Who Will Benefit? Current Market Participants • Find out how you compare to the competition • Assess current and future drivers and restraints • Determine and exploit new market share opportunities New Entrants • Analyze challenges associated with the industry • Calculate time scales for strategy implementation • Position yourself to capitalize on the market’s unmet needs Investment Community • Analyze long-term strategies of companies • Determine which participants will outperform the competition • Assess attractiveness of investing in the market © Copyright 2002 Frost & Sullivan. All Rights Reserved.

Key Market Participants 3 M / Drug Delivery Systems aai. Pharma, Inc. Abbott Laboratories, Ross Products Division Abgenix, Inc. Achillion Pharmaceuticals, Inc. Advanced Immuni T, Inc. Aesgen, Inc. Aethlon Medical, Inc. Agouron Pharmaceuticals, Inc. Alexion Pharmaceuticals, Inc. Allergan, Inc. Allermed Laboratories, Inc. Alpha Therapeutic Corp. Alpharma, Inc. / US Pharmaceuticals Div. Alpha. Vax, Inc. Amgen, Inc. Andrx Corp. Antex Biologics, Inc. Anthra Pharmaceuticals, Inc. Antigenics LLC Aronex Pharmaceuticals, Inc. Astra. Zeneca Pharmaceuticals LP Aventis Pharmaceuticals, Inc. AVI Bio. Pharma, Inc. Barr Laboratories, Inc. Baxter Healthcare Corp. / Hyland-Immuno Div. Bayer Pharmaceutical Division/ Bayer Corp. Bio. Cryst Pharmaceuticals, Inc. Biogen, Inc. Bio. Stratum, Inc. Biosyn, Inc. © Copyright 2002 Frost & Sullivan. All Rights Reserved.

Key Market Participants (Cont’d) Boehringer Ingelheim Pharmaceutical, Inc. Boston Life Sciences, Inc. Bristol-Myers Squibb Co. British Technology Group, USA, Inc. Cell Pathways, Inc. Cell Therapeutics, Inc. Celltech plc Centocor, Inc. Chiron Corp. Corixa Corp. CURA Pharmaceutical Co. , Inc. Cura. Gen Corp. Curis, Inc. Dey Laboratories, Inc. Du. Pont Merck Pharmaceuticals Du. Pont Pharmaceuticals Co. , Inc. Durect Corp. ECR Pharmaceuticals/ E. C. Robins International, Inc. Elan Pharmaceuticals, Inc. / Elan Corp. , plc Eli Lilly & Co. Endo Pharmaceuticals, Inc. Epimmune, Inc. Ferndale Laboratories, Inc. Forest Laboratories, Inc. Fujisawa Healthcare, Inc. Galenica Pharmaceuticals, Inc. Gilead Sciences, Inc. Glaxo. Smith. Kline plc Guilford Pharmaceuticals, Inc. Hoffmann-La Roche, Inc. Hollis-Eden Pharmaceuticals, Inc. Human Genome Sciences, Inc. ICN Pharmaceuticals, Inc. © Copyright 2002 Frost & Sullivan. All Rights Reserved.

Key Market Participants (Cont’d) Immune Response Corp. Immusol, Inc. Indevus Pharmaceuticals, Inc. Inter. Mune Pharmaceuticals, Inc. Ivax Corp. Janssen Pharmaceutica Products L. P. Johnson & Johnson Key Pharmaceuticals, Inc. KOS Pharmaceuticals, Inc. Ligand Pharmaceuticals, Inc. Matrix Pharmaceutical, Inc. Medarex, Inc. Merck & Co. , Inc. / Human Health Division Merz Pharmaceuticals LLC Mylan Laboratories, Inc. Na. Pro Bio. Therapeutics, Inc. Novartis Pharmaceuticals Corp. Novavax, Inc. OSI Pharmaceuticals, Inc. Otsuka America Pharmaceutical, Inc. Otsuka Pharmaceutical Factory, Inc. Pfizer, Inc. Progenics Pharmaceuticals, Inc. Sarawak Medi. Chem Pharmaceuticals, Inc. Schering-Plough Corp. Targeted Genetics Corp. Therion Biologics Corp. Triangle Pharmaceuticals, Inc. Trimeris, Inc. Vax. Gen, Inc. © Copyright 2002 Frost & Sullivan. All Rights Reserved.

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