U S Department of Energy Life and Medical

U. S. Department of Energy Life and Medical Sciences Program Office of Science l Biological Facilities Support of biological stations at world-class synchrotron & neutron sources, JGI, and ORNL mouse house. l Genomics: GTL Systems biology research in bioenergy, bioremediation and carbon sequestration; development of bioenergy research centers. l Health Effects Research - Low Dose Radiation Program - Nuclear Medicine - Advanced bio-medical instrumentation - ELSI, Human Subjects Protection Program

Shewenella Federation PNL, ANL, ORNL, USC, UCLA, MSU, BU. OU, MBL, DRI, BIATECH, GEONOMATICA • Comparative genomic and physiological analysis of Shewenella species. • Functional genomics energy flow and electron transport. • Genetic and functional characterization of c-type cytochromes • Characterization and modeling of metabolic and regulatory networks.

Federation Integrated Approach to Shewanella Biology MR-1 Genome Information Synthesis & Interpretation Sequence, Bioinformatics Linked measurements Concepts & Hypotheses Imaging AFM, EM, CLSM Immuno-EM Computational Biology Physiology & Metabolism Controlled Cultivation ▲ Perturbation: • mutation • cultivation Cellular networks, Modeling Proteomics MS 2 -D gel Data Analysis & Integration Gene Expression Microarrays Reporters

U. S. Department of Energy DOE Imaging Instrumentation Office of Science Clinical PET Micro. PET Mobile PET

U. S. Department of Energy Awake Animal Project : The Rat CAP Office of Science • Miniaturized, novel electronics which allows the signals from the Rat. CAP to be collected, amplified analyzed Rat. CAP • LSO crystal arrays, backed to photodiodes and electronics board. • Image resolution comparable to micro-PET Micro. PET Schlyer, Vaska, Woody, 2006

• Six 16 -electrode devices implanted in humans. Longest implant in for 3 years. • 60 electrode device completing pre-clinical testing in dogs. Human study scheduled for 12/06. • Component design for 250 electrode device completed. ORNL, ANL, LANL, SNL, LLNL, BNL, USC, UC SC, Cal. Tech, NC State, Second Sight