Скачать презентацию U 41 Research resource for Image guided therapy Скачать презентацию U 41 Research resource for Image guided therapy

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U 41: Research resource for Image guided therapy PI: Ferenc Jolesz © 2005 Surgical U 41: Research resource for Image guided therapy PI: Ferenc Jolesz © 2005 Surgical Planning Laboratory, ARR Slide 1

U 41 Image guided therapy • Background & Significance – IGT technology growth – U 41 Image guided therapy • Background & Significance – IGT technology growth – Clinical imaging growth • Aim – Advance and propagate novel image guided procedures • To dev and implement IGT technologies and allow rapid deployment in clinic © 2005 Surgical Planning Laboratory, ARR Slide 2

U 41 program outline • Technology Research & Development cores • Admin core • U 41 program outline • Technology Research & Development cores • Admin core • Biostatistics & Validation core • Collaborations – Internal (11) – External (8) © 2005 Surgical Planning Laboratory, ARR Slide 3

Program outline • 5 TRD cores – Computational • Leader: Ron Kikinis – Imaging Program outline • 5 TRD cores – Computational • Leader: Ron Kikinis – Imaging • Leader: Larry Panych – MRI-guided therapy • Leader: Clare Tempany – Image guided Brain tumor surgery • Leader: Alex Golby – Focused Ultrasound • Leader: Kullervo Hynynen © 2005 Surgical Planning Laboratory, ARR Slide 4

Training & Dissemination • Leaders: John Carrino & Nancy Drinan • Continuous activities on Training & Dissemination • Leaders: John Carrino & Nancy Drinan • Continuous activities on site – First Monday seminars • • R 25 training grant Visiting fellowships Post docs, doctoral students Graduate and undergraduate students © 2005 Surgical Planning Laboratory, ARR Slide 5

Collaborations • Technology based – Advancing imaging and image processing into the OR of Collaborations • Technology based – Advancing imaging and image processing into the OR of the future • AMIGO • Testing utility of IG – Interventional Radiology – Surgery – Cancer therapy – Cardiology (FUS ablation) © 2005 Surgical Planning Laboratory, ARR Slide 6

U 41 Collaborative projects • Internal (11) NIH funded grants – d 2. 1 U 41 Collaborative projects • Internal (11) NIH funded grants – d 2. 1 G CT R 01 AG 19513 MR guided prostate diagnosis and brachytherapy • External (8) NIH grants with BWH collaborators – d 2. 1 p Christos Davatzikos 1 R 01 CA 104976 Targeted prostate biopsy using mathematical optimization © 2005 Surgical Planning Laboratory, ARR Slide 7

External collaborations Major groups • GE – Doumoulin/Pelc • 3 projects stem from the External collaborations Major groups • GE – Doumoulin/Pelc • 3 projects stem from the Engineering research center for computed surgical systems and technology (CISST ERC)of Johns Hopkins – Targeted biopsy (Christos Davatzikos) – Transrectal prostate therapy robot in closed MRI scanner (Gabor Fichtinger) © 2005 Surgical Planning Laboratory, ARR Slide 8

MRI guided therapy core • Neurosurgery • Prostate program • Interventional radiology – Tumor MRI guided therapy core • Neurosurgery • Prostate program • Interventional radiology – Tumor ablation program (SGS 0 – Spine interventions (JC) © 2005 Surgical Planning Laboratory, ARR Slide 9

TRD core and collaborative interactions: An example • Prostate intervention – Paradigm shift • TRD core and collaborative interactions: An example • Prostate intervention – Paradigm shift • Improved image quality – Higher field strength magnets • Magnet design issues – Closed bore systems • MRT core • Internal collaboration • External collaboration © 2005 Surgical Planning Laboratory, ARR Slide 10

Prostate Image guided diagnosis & therapy Detection Staging Brachytherapy FEM Based Deformation Prostate biopsy Prostate Image guided diagnosis & therapy Detection Staging Brachytherapy FEM Based Deformation Prostate biopsy Mutual Information Overlaid Choline/Citrate image Treatment monitoring MR Robotics SPL Infrastructure High Performance Computing Gigabit network Terabyte storage © 2005 Surgical Planning Laboratory, ARR Slide 11

Optimized biopsy project right left Probability of cancer occurrence shown in green (left) and Optimized biopsy project right left Probability of cancer occurrence shown in green (left) and its adaptation (middle) to a stack of segmented intra-operative MR images obtained at the BWH (right). Optimal biopsy sites are transferred to the patient's space. © 2005 Surgical Planning Laboratory, ARR * NIH R 01 PI: Davatzikos et al Slide 12

Validation methods • Pre-clinical – IGT technology-imaging system , guidance and monitoring techniques-organ/disease specific Validation methods • Pre-clinical – IGT technology-imaging system , guidance and monitoring techniques-organ/disease specific • IGT Procedural – Image registration & segmentation • DICE-Statistical analysis of registration matching • Staple-analysis of expert and automated methods – Procedure Feasibility • Safe and effective • Treatment specific -Cancer specific goals – Patient safety, toxicity profiles, Cancer control-long and short term outcomes © 2005 Surgical Planning Laboratory, ARR Slide 13

3 T endorectal coil MRI © 2005 Surgical Planning Laboratory, ARR Slide 14 Bob 3 T endorectal coil MRI © 2005 Surgical Planning Laboratory, ARR Slide 14 Bob Lenkinsky & Neil Rofsky BIDMC

Open vs Closed bore magnet design © 2005 Surgical Planning Laboratory, ARR Slide 15 Open vs Closed bore magnet design © 2005 Surgical Planning Laboratory, ARR Slide 15

1. Tempany CMC, Mc. Neil BJ. Advances in biomedical imaging. JAMA 2000; 285(5): 562 1. Tempany CMC, Mc. Neil BJ. Advances in biomedical imaging. JAMA 2000; 285(5): 562 -567. © 2005 Surgical Planning Laboratory, ARR Slide 16