Скачать презентацию Транспортные системы Транспортеры Механорецепторы Терморецепторы Аквапорины Скачать презентацию Транспортные системы Транспортеры Механорецепторы Терморецепторы Аквапорины

Membrane systems.ppt

  • Количество слайдов: 74

Транспортные системы • • Транспортеры Механорецепторы Терморецепторы Аквапорины Порины Экспортные каналы Токсины Gap junction Транспортные системы • • Транспортеры Механорецепторы Терморецепторы Аквапорины Порины Экспортные каналы Токсины Gap junction

Транспортеры Транспортеры

Model of peptide transport in epithelial cells from intestine and kidney Model of peptide transport in epithelial cells from intestine and kidney

Peptide transporter Membrane domains in green – substrate-binding part; colored residues are critical to Peptide transporter Membrane domains in green – substrate-binding part; colored residues are critical to function

Phylogenetic tree for members of the PTR family Phylogenetic tree for members of the PTR family

Neurotransmitter transporter families Neurotransmitter transporter families

GABA transport GABA transport

Leu transporter from Aquifex aeolicus Leu transporter from Aquifex aeolicus

Leu transporter from Aquifex aeolicus Leu transporter from Aquifex aeolicus

Lactose transporter E. Coli Lactose transporter E. Coli

Lactose transporter E. Coli. Residues involved in substrate or H+ interaction Lactose transporter E. Coli. Residues involved in substrate or H+ interaction

Na+-coupled Glu transporter from Pyrococcus horikoshii (Glt. Ph) Na+-coupled Glu transporter from Pyrococcus horikoshii (Glt. Ph)

Glu transporter from Pytococcus horikoshii Glu transporter from Pytococcus horikoshii

Lactose transporter from E. coli Lactose transporter from E. coli

Механорецепторы Механорецепторы

Mechanosensitive and voltage activated channel from E. Coli of small conductance ~ 1 n. Mechanosensitive and voltage activated channel from E. Coli of small conductance ~ 1 n. S (Msc. S). TM 3 helices lining pore, TM 1 and TM 2 are candidates for the tension and voltage sensor.

Терморецепторы Терморецепторы

корица андрографолид камфора корица андрографолид камфора

Test receptors Test receptors

Аквапорины Аквапорины

Порины Порины

Omp 32 Omp 32

Maltoporin from Salmonella typhimurium Maltoporin from Salmonella typhimurium

Экспортные каналы Экспортные каналы

Model of Acr. B-Acr. A-Tol. C complex in E. coli Model of Acr. B-Acr. A-Tol. C complex in E. coli

Structure of Acr. B from E. coli at 3. 5 A resolution Structure of Acr. B from E. coli at 3. 5 A resolution

Trimeric Acr. B pump from E-coli with large central cavity of 5000 cubic angstroms Trimeric Acr. B pump from E-coli with large central cavity of 5000 cubic angstroms

To. IC & OM proteins To. IC & OM proteins

To. IC To. IC

ATP dependent drug efflux system ATP dependent drug efflux system

Msb. A (E. coli) Msb. A (E. coli)

ABC transporter proteins ABC transporter proteins

ATP-induced conformational changes Mod. BC-A Sav 1866 ATP-induced conformational changes Mod. BC-A Sav 1866

Токсины Токсины

a-Hemolysin (Staphylococcus aureus) Mr 33, 2 k. Da 16 b-strands heptamer a-Hemolysin (Staphylococcus aureus) Mr 33, 2 k. Da 16 b-strands heptamer

Yersinia protein injectisome Yersinia protein injectisome

Modeles of type III (T 3 SS) and type IV (T 4 SS) secretion Modeles of type III (T 3 SS) and type IV (T 4 SS) secretion systems

Gap junction Gap junction