Скачать презентацию The development of biologically active medication to treat Скачать презентацию The development of biologically active medication to treat

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The development of biologically active medication to treat TBC patients Malkov S. А. , The development of biologically active medication to treat TBC patients Malkov S. А. , Shironosov O. V. , Shironosova G. I.

PROBLEM TOPICALITY WHO declared TBC the global danger in 1993. Every year TBC causes PROBLEM TOPICALITY WHO declared TBC the global danger in 1993. Every year TBC causes the following: l 1 billon people infection; l 8 -10 billion people illness; l 3 -4 billion people death.

Modern TBC patient treatment Is expensive (the average cost of one bed day 1600 Modern TBC patient treatment Is expensive (the average cost of one bed day 1600 rubles); l Causes poisonous effect; l Requires long-term (4 -6 months) administration; l Is aggravated by multidrug resistance. l

Galleria Mellonella – The Greater Wax Moth l l l I. I. Mechnikov (1889); Galleria Mellonella – The Greater Wax Moth l l l I. I. Mechnikov (1889); S. А. Mukhin (1955); N. А. Spiridonov (1989). Extract's properties: 1. Immune protective; 2. Antimicrobial; 3. Antioxidant.

HOW TO GET A BIOACTIVE PRODUCT FROM THE GREATER WAX MOTH LARVAE (21)4938002/14 (22) HOW TO GET A BIOACTIVE PRODUCT FROM THE GREATER WAX MOTH LARVAE (21)4938002/14 (22) 2603. 91 (46)2706. 95 Bulletin № 18 (71) Institute of Theoretical and Experimental Biophysics, USSR Academy of Sciences (72) Spiridonov. NA; Rachkov. AK; Mukhin SA; Kondrashova. MN. (73) Spiridonov. Nikolay Aleksandrovich (55) USSR certificate of authorship 1284229, А 61 К 35/04. 1989. N

The way of noncontact activation Solutions with negative redox potential are deoxidants; have powerful The way of noncontact activation Solutions with negative redox potential are deoxidants; have powerful antioxidant features; improve permeability of biological membranes; improve the protective features of organism.

THE PROJET’S AIM is the development of bioactive medication (with long-lasting redox potential) on THE PROJET’S AIM is the development of bioactive medication (with long-lasting redox potential) on the basis of water solutions of The Greater Wax Moth larvae to treat TBC patients.

DYNAMICS OF REDOX POTENTIAL CHANGE Date Control (redox potential , m. V) Experiment (redox DYNAMICS OF REDOX POTENTIAL CHANGE Date Control (redox potential , m. V) Experiment (redox potential , m. V) 09. 07. 11 12. 08. 11 18. 08. 11 24. 08. 11 06. 09. 11 80 84 82 79 83 -193 -248 -301 -445 -476

Clinical research Republican tuberculosis dispensary: l l l 15 patients; Infiltrative TB. Average - Clinical research Republican tuberculosis dispensary: l l l 15 patients; Infiltrative TB. Average - 40 years; Gender - male; Treatment duration – 3, 5 months.

Research results ltwofold reduction of abacillary duration; lreduction of intoxication; limprovement of blood value Research results ltwofold reduction of abacillary duration; lreduction of intoxication; limprovement of blood value (reduction of the number of lymphocytes, improvement of differential blood cell count, ESR reduction, etc. ).

Commercialization perspectives Bed day shortening by 1, 5 -2 times. l Treatment course depreciation. Commercialization perspectives Bed day shortening by 1, 5 -2 times. l Treatment course depreciation. l Increase of medication’s biological activity. l

Demand assessment after launching: 1 st year (USD) 3 rd year (USD) Russia 50 Demand assessment after launching: 1 st year (USD) 3 rd year (USD) Russia 50 000 200 000 CIS countries 70 000 300 000 ЕС countries, USA 100 000 350 000

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