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Survival following VAD complications: implications for transplant priority. Todd Dardas, MD, MS May 16, Survival following VAD complications: implications for transplant priority. Todd Dardas, MD, MS May 16, 2015

Disclosures • Funding: – American College of Cardiology/Sankyo Daiichi Career Development Grant Disclosures • Funding: – American College of Cardiology/Sankyo Daiichi Career Development Grant

Candidate survival Wever-Pinzon, O, et. al. ; Circulation 2012 Candidate survival Wever-Pinzon, O, et. al. ; Circulation 2012

Cumulative Mortality Status 1 A: Indexed by “first status” Ventilator Paracorporeal Exception VAD Complication Cumulative Mortality Status 1 A: Indexed by “first status” Ventilator Paracorporeal Exception VAD Complication IABP/Dual Inotrope Implanted VAD 0. 4 0. 3 0. 2 0. 1 0 0 15 30 45 60 Days from initial listing Dardas T, et al J Am Coll Cardiol 2012 75 90

Status 1 A exceptions Meyer D, et. al. American Journal of Transplantation 2015; 15: Status 1 A exceptions Meyer D, et. al. American Journal of Transplantation 2015; 15: 44– 54

UNOS 1 A(b) justifications 4% 15% 11% Thrombosis Infection Device malfunction 18% 52% Arrhythmias UNOS 1 A(b) justifications 4% 15% 11% Thrombosis Infection Device malfunction 18% 52% Arrhythmias Other Unpublished data, UNOS registry

Tier Proposals 1. MCS with arrhythmias, non-dischargeable VAD 2. Device malfunction, IABP 3. MCS Tier Proposals 1. MCS with arrhythmias, non-dischargeable VAD 2. Device malfunction, IABP 3. MCS (infection, thromboembolism, other complications), LVAD 30 days, dual inotropes 4. Inotrope w/o HD monitor, stable VAD 5. Multi-organ transplants 6. Remaining candidates Meyer D, et. al. American Journal of Transplantation 2015; 15: 44– 54

Guidance from OPTN 1. 2. 3. 4. 5. 6. 7. 8. Aortic insufficiency Hemolysis Guidance from OPTN 1. 2. 3. 4. 5. 6. 7. 8. Aortic insufficiency Hemolysis Pump thrombosis Pump-related local or systemic infection Bleeding Right heart failure Recrudescent arrhythmias Device malfunction Meyer D, et. al. American Journal of Transplantation 2015; 15: 44– 54

OPTN infection guidance Pump-related or systemic infection with one of: • Symptoms along driveline OPTN infection guidance Pump-related or systemic infection with one of: • Symptoms along driveline with leukocytosis AND: + blood culture or + site culture • Surgical debridement of the driveline AND + site culture • + Pump pocket culture • Bacteremia with the same organism 4 weeks following treatment Meyer D, et. al. American Journal of Transplantation 2015; 15: 44– 54; http: //www. uab. edu/medicine/intermacs/appendices-4 -0/appendix-a-4 -0

Research aims • Determine mortality for complications following CF VAD placement and compare to Research aims • Determine mortality for complications following CF VAD placement and compare to non-MCS UNOS candidates. • Evaluate whether subgroups within complications have distinct risks useful for ranking in the tier system.

Methods • INTERMACS data for all primary implants of CF devices implanted between 4/2012 Methods • INTERMACS data for all primary implants of CF devices implanted between 4/2012 and 3/2014 • DT and BTT included unless otherwise specified • Complications: – – – Multiple complications per time point First and isolated complication First infection of any number reported • OPTN/UNOS registry data for patients without MCS

Sample Complications/ interval Strategy Other 0 1 2 3 4 5 6 7 BTT Sample Complications/ interval Strategy Other 0 1 2 3 4 5 6 7 BTT BTE DT Total 5 162 53 12 1 1 0 0 151 2, 607 808 118 24 9 1 0 186 4, 320 1, 385 207 44 9 4 4 299 6, 011 2, 052 342 87 17 3 0 641 13, 100 4, 298 679 156 36 8 4

Outcome • Death during VAD support • Censoring at transplant or recovery Outcome • Death during VAD support • Censoring at transplant or recovery

Sample • • • 4725 primary CF VAD implants 22, 524 complications 2975 1 Sample • • • 4725 primary CF VAD implants 22, 524 complications 2975 1 st and isolated complications No AE report n=641 Final cohort: n= 3616

Mortality following first complication N = 3616 Mortality following first complication N = 3616

Freedom from major complication Major Complications: INTERMACS 1 0. 8 0. 6 0. 4 Freedom from major complication Major Complications: INTERMACS 1 0. 8 0. 6 0. 4 0. 2 0 0 365 730 1095 Days since implant Kirklin J et. al. , J Heart Lung Transplant 2013 1460

INTERMACS AEs Hemolysis Other SAE Respiratory Failure Neurological Dysfunction Right Heart Failure Hepatic Dysfunction INTERMACS AEs Hemolysis Other SAE Respiratory Failure Neurological Dysfunction Right Heart Failure Hepatic Dysfunction Venous Thromboembolism Cardiac Arrhythmias Device Malfunction Hypertension Wound Dehiscence Pericardial Fluid Collection Major Bleeding Myocardial Infarction Arterial Non-CNS embolism Psychiatric Episode Major Infection Renal Dysfunction

Mortality following first AE reported Adverse Event Cumulative hazard at 90 days following report Mortality following first AE reported Adverse Event Cumulative hazard at 90 days following report Std. err. Renal Dysfunction 0. 46 Neurological Dysfunction 0. 45 0. 09 Status 1 A 0. 10 Respiratory Failure 0. 21 0. 04 Device Malfunction 0. 21 0. 10 Right Heart Failure 0. 17 0. 04 Bleeding 0. 15 0. 02 Pericardial Drainage 0. 12 0. 05 Infection 0. 12 Other SAE 0. 10 Status 1 B 0. 02 Venous Thromboemb. 0. 08 0. 06 Hemolysis 0. 07 0. 05 Cardiac Arrhythmia 0. 07 0. 01 Psychiatric Episode 0. 05 0. 03

st 1 Infection AE N= 4632 st 1 Infection AE N= 4632

Adjusting for initial device strategy Variables Hazard ratio P-value AE infection 3. 1 <0. Adjusting for initial device strategy Variables Hazard ratio P-value AE infection 3. 1 <0. 0001 DT Ref BTT 0. 58 <0. 0001 BTE 0. 67 <0. 0001 Other strategy 0. 97 0. 92

Comparison to OPTN Status 1 A Status 1 B Comparison to OPTN Status 1 A Status 1 B

Infection Definition OPTN One of: • Symptoms along driveline with leukocytosis AND: • + Infection Definition OPTN One of: • Symptoms along driveline with leukocytosis AND: • + blood culture • + site culture • Surgical debridement AND + site culture • + pump pocket culture • Bacteremia 4 wks s/p treatment INTERMACS • Localized non-device • Driveline or pump pocket • Sepsis • Internal pump component Meyer D, et. al. American Journal of Transplantation 2015; 15: 44– 54; http: //www. uab. edu/medicine/intermacs/appendices-4 -0/appendix-a-4 -0

INTERMACS subgroups All p-values <0. 01 vs. No infection AE INTERMACS subgroups All p-values <0. 01 vs. No infection AE

Adjusted for initial device strategy Variable Hazard ratio P-value Infection AE No Inf. AE Adjusted for initial device strategy Variable Hazard ratio P-value Infection AE No Inf. AE reported Ref Localized, non-VAD 3. 2 <0. 0001 Perc. lead/pocket 1. 9 <0. 0001 Device component 8. 5 0. 003 Sepsis 3. 8 <0. 0001 DT Ref BTT 0. 58 <0. 0001 BTE 0. 68 <0. 0001 Other 0. 95 0. 86 Strategy

INTERMACS AEs & OPTN status Driveline vs. No inf. AE p=0. 13 All other INTERMACS AEs & OPTN status Driveline vs. No inf. AE p=0. 13 All other p-values <0. 01 Status 1 A Status 1 B

Tier Proposals 1. MCS with arrhythmias, non-dischargeable VAD 2. MCS sepsis OR pump pocket/internal Tier Proposals 1. MCS with arrhythmias, non-dischargeable VAD 2. MCS sepsis OR pump pocket/internal device infection OR localized infection, IABP 3. MCS driveline infection, thromboembolism, LVAD 30 days, dual inotropes 4. Inotrope w/o HD monitor, stable VAD Meyer D, et. al. American Journal of Transplantation 2015; 15: 44– 54

Considerations • How should continued eligibility be weighted in priority decisions? Considerations • How should continued eligibility be weighted in priority decisions?

Changing device strategy Teuteberg J, et. al. J Am Coll Cardiol HF 2013 Changing device strategy Teuteberg J, et. al. J Am Coll Cardiol HF 2013

BTT vs DT: 90 -day mortality AE type BTT DT DT - BTT Bleeding BTT vs DT: 90 -day mortality AE type BTT DT DT - BTT Bleeding 0. 12 0. 18 0. 06 Cardiac Arrhythmia 0. 01 0. 12 0. 11 Infection 0. 14 0. 12 -0. 02 Neurological Dysfunction 0. 22 0. 59 0. 37 Other SAE 0. 02 0. 16 0. 13 Psychiatric Episode 0. 07 0. 00 -0. 07 Renal Dysfunction 0. 24 0. 55 0. 30 Respiratory Failure 0. 23 0. 28 0. 05 Right Heart Failure 0. 08 0. 23 0. 15

Considerations • How many subgroups should be identified analyzed? Considerations • How many subgroups should be identified analyzed?

Stratified complications? Yes • Infections • Right heart failure • Bleeding • Hemolysis Maybe Stratified complications? Yes • Infections • Right heart failure • Bleeding • Hemolysis Maybe • Device malfunction No • Ventricular arrhythmias • Thrombosis • Aortic regurg.

Conclusions Subgroups of patients within broad complication types may warrant further characterization and stratification Conclusions Subgroups of patients within broad complication types may warrant further characterization and stratification by INTERMACS definitions

 • • • Susan Meyer Frank Pagani Kent Shively • • • Susan Meyer Frank Pagani Kent Shively

Mortality following first AE reported Cumulative hazard at 90 days following report Std. err. Mortality following first AE reported Cumulative hazard at 90 days following report Std. err. At risk Deaths Renal Dysfunction 0. 46 0. 09 53 30 Neurological Dysfunction 0. 45 0. 10 56 24 Respiratory Failure 0. 21 0. 04 95 22 Device Malfunction 0. 21 0. 10 38 5 Right Heart Failure 0. 17 0. 04 170 29 Bleeding 0. 15 0. 02 367 55 Pericardial Drainage 0. 12 0. 05 46 6 Infection 0. 12 0. 02 238 25 Other SAE 0. 10 0. 02 224 22 Venous Thromboemb. 0. 08 0. 06 23 2 Hemolysis 0. 07 0. 05 33 2 Cardiac Arrhythmia 0. 07 0. 01 291 22 Psychiatric Episode 0. 05 0. 03 41 2 Adverse Event

Risk of first AE relative to Status 1 A/B Status 1 A Status 1 Risk of first AE relative to Status 1 A/B Status 1 A Status 1 B