Stephen E Fish Ph D Mitchell L Berk

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Stephen E. Fish, Ph. D. Mitchell L. Berk, Ph. D. Marshall University J. C. E. School of Medicine

Note to instructors: I use these Power. Point slides in histology lectures that I give to first year medical students. Copy the slides, or just the images into your own teaching media. We all know that teaching science often requires compromises and simplification for specific student populations, or the requirements of a specific course. Please feel free to offer suggestions for improvements, corrections, or additional illustrations. I would be pleased to hear from anyone who finds my work useful, and am always willing to make it better. Also, the images have been compressed to screen resolution to keep Power. Point file size down, and I can provide them at any resolution. Contact me about the illustrations and Mitchell L. Berk about the photomicrographs. Stephen E. Fish, Ph. D. Fish@Marshall. edu Berk@Marshall. edu

Blood & lymph vessels

Vessels have a common plan of layers

A little about elastin in the media • It is made by the smooth muscle cells • Elastin fibers predominate in small arteries • Elastic laminae predominate in large arteries – They are like inner tubes, one inside another – But they are perforated to allow access to O 2 & nutrients – They appear wrinkled in most slides because the smooth muscle often contracts in death

Very large arteries- aorta Artifactual crack Intima Adventitia Media Vasa vasorum

Aorta detail This is so dark because it is stained for elastin (Intima is missing on many slides) Intima Internal elastic lamina hard to see, look for others in the media Endothelium Media

Dense irregular CT of adventitia with elastic stain Aorta detail Media Vasa vasorum Crack External elastic lamina

Muscular arteries (medium size) Media- elastic lamina faint or nonexistent, mostly elastin fibers Intima very thin Internal elastic lamina Adventitia

Arterioles • Minimal intima & 1 - 3 muscle layers • In media a few elastin fibers & no laminae • Normal constriction (vasomotor response) is important for regulating capillary blood flow

Capillaries supplying sweat glands with water & proteins • Capillaries consist of endothelial cells & their basement membrane • The only layer is the intima