Rubor, calor, tumor: histamine Dolor: PGE 2 bradykinin

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РЕГИСТРАЦИЯ

Rubor, calor, tumor: histamine Dolor: PGE 2 bradykinin

Vascular leakage: vendothelial cell contraction vendothelial cell retraction valterations in transcytosis(VEGF) vdirect injury v. Indirectly by leukocyte-mediated damage

ПЛАЗМЕННЫЕ

C 3 a and C 5 a. B 1 receptors B 2 receptors

decayaccelerating factor (DAF) C 1 esterase inhibitor (C 1 INA) Protectin (CD 59)

клеточные

v Hsp 27, Hsp 70, Hsp 90 v substance P (SP) v neurokinins A (NKA) and // B (NKB)

Mediators have diverse functions including: a. Vasodilation • Examples — histamine, nitric oxide, PGI 2 b. Vasoconstriction • Example—thromboxane A 2 (TXA 2) c. Increasing venular permeability • Examples — histamine, bradykinin, LTC 4, LTD 4, LTE 4, ……C 3 a, . and C 5 a (anaphylatoxins) d. Producing pain • Examples — PGE 2, bradykinin e. Producing fever • Examples — PGE 2, IL-1, TNF f. Chemotaxis • Examples — C 5 a, LTB 4, IL-8 g. Liver synthesis of acute phase reactants (APRs; e. g. , …. . fibrinogen, ferritin, complement, …. . hepcidin, C-reactive protein) • IL-6 stimulates APR synthesis.