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Roger Prichard and Catherine Bourguinat Institute of Parasitology Centre for Host-Parasite Interactions Mc. Gill Roger Prichard and Catherine Bourguinat Institute of Parasitology Centre for Host-Parasite Interactions Mc. Gill University Sainte Anne-de-Bellevue, Québec

Focus of presentation: Focus of presentation:

The diseases The diseases

Burden of high prevalence NTDs Lancet 2009) Disease (modified from Hotez et al. DALYs Burden of high prevalence NTDs Lancet 2009) Disease (modified from Hotez et al. DALYs (million) Deaths /yr Global prevalence Control Lymphatic filariasis 5. 8 500 120 m MDA (ABZ Hookworms 1. 8 -22. 1 3, 00065, 000 600 m MDA (ABZ) Ascariasis 1. 2 -10. 5 3, 00060, 000 800 m MDA (ABZ) Trichuriasis 1. 6 -6. 4 3, 00010, 000 600 m MDA (ABZ) Onchocerciasis 1. 5 500 37 m MDA (IVM) Schistosom -iasis 1. 7 -4. 7 15, 000280, 000 200 m MDA (PZQ) +DEC/IVM)

Lymphatic Filariasis -1. 2 billion people in 83 countries at risk -120 million people Lymphatic Filariasis -1. 2 billion people in 83 countries at risk -120 million people infected worldwide -India, Indonesia, Nigeria and Bangladesh (account for 70 % of global lymphatic filariasis infections) -Estimates of annual economic loss in India due to lymphatic filariasis US $1 b -Lymphoedema, hydrocele, elephantiasis, impaired motility, social stigma

Soil-transmitted helminths Soil-transmitted helminths

Onchocerciasis- River Blindness -Onchocerciasis –blindness, visual impairment, severe skin pathology - greatly reduces income-generating Onchocerciasis- River Blindness -Onchocerciasis –blindness, visual impairment, severe skin pathology - greatly reduces income-generating capacity, incurs significant health expenditures, reduces life expectancy and exerts a very negative socioeconomic impact on the afflicted populations and land use -Currently, via APOC/OEPA, more than 40 million people receive regular ivermectin treatment through a community drug-distribution Distribution of Onchocerciasis/Current Status of Global Onchocerciasis Control

Schistosomiasis - 200 million people infected; half in Africa (650 million people live in Schistosomiasis - 200 million people infected; half in Africa (650 million people live in endemic areas) - 2 nd most socioeconomically devastating parasitic disease, after malaria - Anemia, malnutrition, impaired cognitive development, damage to liver, intestines, lungs, bladder (bladder cancer), hepatosplenomegaly - Found in 74 tropical countries. -3 main species of Schistosome in humans – -The drug praziquantel costs 18 cents per dose - >423 million tablets PZQ needed globally/year to treat schistosomiasis

Lymphatic filariasis: Treatment and control Lymphatic filariasis: Treatment and control

HEALTH IMPACT: ‘BEYOND LF’ BENEFITS HEALTH IMPACT: ‘BEYOND LF’ BENEFITS

HEALTH IMPACT: ‘BEYOND LF’ BENEFITS HEALTH IMPACT: ‘BEYOND LF’ BENEFITS

STH: Treatment & control STH: Treatment & control

Onchocerciasis: Treatment & control Onchocerciasis: Treatment & control

Schistosomiasis: Treatment & control Schistosomiasis: Treatment & control

General opportunities for NTD General opportunities for NTD

Challenges Challenges

Conclusions: Conclusions: