Research in the Emory School of Medicine David

Research in the Emory School of Medicine David Stephens Jeff Sands Trish Haugaard October 2006

Emory University Hospital Yerkes Primate Research Ctr. GCRC VA-Research Ctr CRCA/MSCR/K 30/K 12 Wesley Woods Crawford Long Hospital CDC

Research progress at Emory SOM 1979: $105 M Woodruff gift 1986: 5 th strategic plan for research: goal - national prominance 1986: Juha Kokko, Chair Dept. Medicine 1988: Jeff Houpt, Dean 1990 -95: 9 new chairs appointed; new space – Rollins Bldg & WRMB wing 1996: Tom Lawley, Dean; Mike Johns, VP WHSC 1997: 6 th Strategic plan for research: goal – expand workforce 1996 -05: 14 new chairs appointed; >160 new NIH-funded investigators 1996 -05: new space: Vaccine Center, Whitehead, WCI, Pediatrics, Yerkes Neuroscience; lose space – A&P building 1999: Biomed. Engineering Department, Don Giddens Chair 2000: Em. Tec-Bio incubator 2003: 7 th strategic plan for research: goal – team science 2005: capital campaign

Growth rate of NIH funding 1996 -2005 benchmark Schools Rank 19 15 9 13 5 2 4 1 17 11 18 7 SOM Emory Univ. Vanderbilt Univ. of Pittsburgh Baylor College Duke Univ. of Penn. Washington Univ. Johns Hopkins U. Univ. of NC Stanford Univ. UAB Yale Univ. 1996 2005 $ millions 55 71 99 89 128 149 162 204 132 98 159 190 244 288 257 350 399 378 449 217 264 191 298 Ave. Annual Compound Growth Rate 14. 8% 12. 6% 12. 5% 11. 9% 11. 6% 9. 8% 9. 2% 8. 6% 8. 0% 7. 7% 7. 2%

Top-20 ranked SOM departments (2005 NIH Funding) Clinical departments • • Otolaryngology (3) Emergency Medicine (3) Surgery (8) Dermatology (9) Pathology & Lab Medicine (8) Neurology (11) Urology (11) Physical Medicine & Rehabilitation (14) • Psychiatry & Behavioral Sciences (17) • Neurosurgery (20) Basic science departments • Biomedical Engineering (1) • Microbiology & Immunology (7) • Pharmacology (11)

Selected recent achievements 2003 • • $16 M for vaccine research (R Ahmed) $12 M for emerging infections and bio-defense $10 M + $7. 6 M for prostate metastasis study (L Chung, J Simons) $7 M for alcohol link to acute respiratory distress syndrome (M Moss) 2004 • Chris Larsen “Roche Basic Science Award” by Amer. Soc. Transplantation • $4. 9 M to develop drugs for depression (C. Nemeroff) 2005 • • • Top 10 “best work environment for postdocs” – The Scientist $25 M for cancer nanotechnology (S Nie) $11. 5 M for cardiovascular nanomedicine (G Bao) $9 M for small molecule discovery (R Dingledine) $7. 4 M for Alzheimer’s Center (A. Levey) $525 M received for sale of 3 TC (D. Liotta, R. Schinazi)

Selected recent achievements 2006 • $7. 5 M to WCI Lung Cancer Research • $10 M to Emory’s Transplant Center, Vaccine Center, and Yerkes for development of new vaccine strategies • 42 SOM investigators now have $1 M+ in NIH awards • Vision 2012 – two new research buildings proposed – 1523 Clifton Road – As part of the new Medical Research Complex

Strategic Plans for Research 1946 Glenville Giddings Develop SOM on Emory campus, not Grady 1952 Boisfeuillet Jones Establish Emory Clinic 1960 Boisfeuillet Jones Build new space 1967 Art Richardson Improve quality, not quantity 1986 Ken Walker Strive for national prominance 1996 Wright Caughman & Ray Dingledine Expand research workforce 2003 Wright Caughman & Ray Dingledine Focus on team science & translational research

2003 Strategic Plan for Research Goal • Accelerate our progress towards top-tier status as a medical research enterprise Mechanisms • • Grow space, infrastructure and investigators Promote translational & team science

Strategic Plan for Research: 2008 goals Culture • Improve integration of research and clinical missions People • Increase the number of NIH funded investigators by ~100 • Attend to retention as well as recruitment • Increase # grad students from 322 to ~500, MD/Ph. Ds from 8% to 12% of entering class, and postdocs from 420 to 630 Programs • Build new research space (550, 000 gsf) • Build team science research from 18 to 25% of NIH income • Increase investment in enabling technologies & research cores

Seven Research Areas for Emphasis 1. Cancer 2. Neurosciences 3. Immunity and Host Defense 4. Cardiovascular and Epithelial Biology 5. Regenerative, Transplantation and Reparative Medicine 6. Integrative Medicine and Health Services Research 7. Molecular Structure and Interactions

Plan of Action for NIH RFA for Clinical and Translational Science Award (CTSA) The purpose of this initiative is to forge a uniquely transformative, novel and integrative academic home for clinical and translational science.

CTSA It should: 1. Captivate, advance and nurture a cadre of well-trained multi- and inter-disciplinary investigators and research teams. 2. Create an incubator for innovative research tools. 3. Synergize multi- and inter-disciplinary clinical and translational research.

CTSA • • • U 54 Cooperative Agreement Mechanism Application Due January 2007 $6 million/yr. for 5 years total costs 8 awards made in 2006 NIH plans to award up to 60 awards by 2010 -2012

Research Resources • Clinical Trial Office (Peter Block) • GCRC (Arlene Chapman) • Research core facilities • • • Microchemical and proteomics BIMCORE DNA sequencing Flow cytometry Microscopy Animal imaging Biomedical imaging technology MRI center PET center Transgenic mouse Human tissue procurement & banking Human embryonic stem cell

Additional SOM CORE FACILITIES • • • Animal Imaging BIMCORE Biomedical Imaging Technology Center DNA Sequencing Flow cytometry Human Tissue Procurement & Banking Microchemical & Proteomics Microscopy MRI Center Positron Emission Tomography Center Transgenic Mouse & Gene-Targeting

NEW CHALLENGES • NIH FUNDING • Budget growth shrinking • 90% of grant applications not funded • 1% across-the-board cut on all discretionary spending translating into a $286 M reduction in NIH spending

NEW CHALLENGES • Grants. gov • • • Electronic Submission system not ready SR 424 very different than PHS 398 Change from % effort to # of person months No internal electronic routing system (yet) Earlier internal submission deadlines required

GRANT POINTERS • Submit your grant to multiple funding agencies, such as NIH, VA, AHA, others • Write your grant at least a month in advance of the deadline • Have people who know the field read it • Have people NOT in the field read it • Do not submit just to submit – it is better to get it right (or close) than to get triaged