Скачать презентацию Основные сигнальные пути от рецепторов факторов роста GF Скачать презентацию Основные сигнальные пути от рецепторов факторов роста GF

2 Cytokine STAT PI3K.ppt

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Основные сигнальные пути от рецепторов факторов роста GF GF receptor Ras. GDP TK TK Основные сигнальные пути от рецепторов факторов роста GF GF receptor Ras. GDP TK TK p. Y IP 3 + DAG p. Y Ca PKC 2+ PLC PIP 2 PIP 3 p. Y Ras. GTP Sos Grb 2 p. Y Shc Raf p. S MEK p 110 p 85 p. Y PI-3 K p. Y STAT p. Y p. T ERK PKB STAT p. Y STAT DNA Transcription factors etc.

STAT proteins – signal transducers and activators of transcription STAT proteins – signal transducers and activators of transcription

Cytokine receptors Cytokine receptors

Cytokine receptors, JAKs and STATs Cytokines Signaling molecules Type I Cytokines utilizing γc IL-2, Cytokine receptors, JAKs and STATs Cytokines Signaling molecules Type I Cytokines utilizing γc IL-2, IL-7, IL-9, IL-15 IL-4 Jak 1, Jak 3 Stat 5 Stat 6 Cytokines utilizing βc GM-CSF, IL-3, IL-5 Jak 2 Stat 5 Cytokines utilizing gp 130 IL-6, IL-11, CNTF, LIF, oncostatin M IL-12 Jak 1, Jak 2, Tyk 2 Stat 3 Jak 2, Tyk 2 Stat 4

Cytokine receptors, JAKs and STATs Cytokines Signaling molecules* Cytokines utilizing homodimeric receptor GH Jak Cytokine receptors, JAKs and STATs Cytokines Signaling molecules* Cytokines utilizing homodimeric receptor GH Jak 2 Prolactin Jak 2 Erythropoietin, thrombopoietin Jak 2 G-CSF, leptin Jak 2 Type II IFN-α/β IFN-γ IL-10 IL-20 Stat 5 b Stat 5 a Stat 5 Stat 3 Jak 1, Tyk 2 Stat 1, Stat 2 Jak 1, Jak 2 Stat 1 Jak 1, Tyk 2 Stat 3 ? Stat 3

STAT proteins – signal transducers and activators of transcription STAT proteins – signal transducers and activators of transcription

STAT proteins STAT proteins

The molecular structure of STAT 1 complex with DNA The molecular structure of STAT 1 complex with DNA

The stages of STAT activation from cytokine receptor or from growth factor receptor The stages of STAT activation from cytokine receptor or from growth factor receptor

STAT proteins STAT proteins

The differentiation of the T-helper cells Th 0 IL-4 STAT 6 IL-12 STAT 4 The differentiation of the T-helper cells Th 0 IL-4 STAT 6 IL-12 STAT 4 SOCS-1 Th 2 Th 1

Negative regulation of STATs Negative regulation of STATs

PI-3 kinase (phosphoinositide-3 kinase) PI-3 kinase (phosphoinositide-3 kinase)

Phosphatidylinositol phosphorylation Phosphatidylinositol phosphorylation

The classes of the PI-3 kinases The classes of the PI-3 kinases

Targets of the PI-3 kinase products Targets of the PI-3 kinase products

Survival pathways from PKB PI-3 kinase PI-3, 4 -P 2, PI-3, 4, 5 -P Survival pathways from PKB PI-3 kinase PI-3, 4 -P 2, PI-3, 4, 5 -P 3 m. TORC 2 PDK 1 PKB/Akt Mdm 2 Fox. O GSK 3 Bad Apoptosis NFk. B p 53

PI-3 kinase and cell cycle PI-3 kinase and cell cycle

Regulation of cell metabolism by PI-3 kinase Regulation of cell metabolism by PI-3 kinase

Regulation of glycogen synthesis by PI-3 kinase Synip/syntaxin 4 ISPK GSK-3 PP 1 G Regulation of glycogen synthesis by PI-3 kinase Synip/syntaxin 4 ISPK GSK-3 PP 1 G Glycogen synthase Glycogen

Regulation of translation Erk 1, Er k 2, p 38 P T ranslation activ Regulation of translation Erk 1, Er k 2, p 38 P T ranslation activ ated MNK 1 4 G GTP GDP C e. IF 2 P e. IF 2 B GSK 3 4 A 4 E m 7 G 4 G N P AUG. . . A A AAAAA 4 G M 3 4 E-BPs P 40 S 6 S P m. TOR p 70 6 SK 4 E m 7 G AUG. . . A A AAAAA 4 E-BPs T ranslation inhibited MNK 1 4 G C 4 A 4 G N 4 G M

Regulation of PI-3 kinase/Akt by metabolites Regulation of PI-3 kinase/Akt by metabolites

Glycogen synthase kinase (GSK-3 beta) PI-3 kinase Integrins Wnt ERK Akt/PKB ILK p 90 Glycogen synthase kinase (GSK-3 beta) PI-3 kinase Integrins Wnt ERK Akt/PKB ILK p 90 RSK Dsh GSK-3 Glycogen synthase c-jun Cy. D -catenin e. IF-2 B

Major PI-3 kinase dependent GEFs for Rac PI-3 K PIP 2(3, 4) PIP 3(3, Major PI-3 kinase dependent GEFs for Rac PI-3 K PIP 2(3, 4) PIP 3(3, 4, 5) Vav 1 Vav 2 Rac SWAP-70 P-Rex 1 Dock 180 (indirect)