Organs for research and education Matthew Bock
When are organs used for research? Only after they have been determined unsuitable for transplant
What makes an organ unsuitable for transplant? n n Performance Condition
Performance Kidneys Creatinine Liver AST/ALT Pancreas A 1 C Heart Troponin, Echo Lungs X-ray, PO 2
Condition n Fatty pancreas Polycystic kidney Fibrotic or fatty liver
If we can’t transplant… There is still an option… Research consent
Page 2 (back) of consent form
Page 2 (back) of consent form
Research consent for transplanted organs n Liver study n n Lung study n n Biopsy Bronch washings and blood ample Kidney study
Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National
Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National
Order n n 1 st - Transplant 2 nd- In-house research n n Pancreas islet cells 3 rd - National
Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National
Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National n n NDRI IIAM
Who are NDRI and IIAM? n NDRI, National disease research interchange IIAM, International Institute for the Advancement of Medicine n Both are 501 c non-profit n
Heart, Arteries and Veins Medical investigators use the human heart to learn about the development of atherosclerosis in coronary arteries
Kidneys Renal tissues is used to study the toxicity of anti-cancer therapies and to study the safe concentrations of other drugs in development
Lungs Research into chronic obstructive pulmonary disease (COPD), cystic fibrosis, asthma, emphysema and allergies
Pancres Diabetes researchers rely on pancreatic tissues to explore the regulation of insulin production, to identify the genetic components of the disease and for toxicity studies on new compounds.
Liver n n Hepatocyte cell isolation for transplantation Human model for drug interaction, toxicity and metabolism testing
Education n Whole body donation
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