Скачать презентацию Optical Biopsies in Neurosurgery Raman Spectroscopy Raman Скачать презентацию Optical Biopsies in Neurosurgery Raman Spectroscopy Raman

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Optical Biopsies in Neurosurgery: Raman Spectroscopy Optical Biopsies in Neurosurgery: Raman Spectroscopy

Raman Spectroscopy Raman Spectroscopy

The First Step towards Precision Medicine “Coupling established clinical– pathological indexes with state-ofthe-art molecular The First Step towards Precision Medicine “Coupling established clinical– pathological indexes with state-ofthe-art molecular profiling to create diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient's requirements”. Mirnezami, R. , J. Nicholson, and A. Darzi, Preparing for precision medicine. N Engl J Med, 2012. 366(6): p. 489 -91.

Aims: Pilot Study 1. To determine the diagnostic accuracy of Raman spectroscopy in a Aims: Pilot Study 1. To determine the diagnostic accuracy of Raman spectroscopy in a prospective study of brain tumours 2. To determine if a Raman spectral fingerprint exists in vivo to identify patients with a better prognosis 3. To develop a novel methodology for Raman fibreoptic deployment and test it in vivo

Identification of Tumour Raman • Clear difference in Raman spectra between normal and tumour Identification of Tumour Raman • Clear difference in Raman spectra between normal and tumour tissue (right) • Data also separates according to intrinsic tumour grade (above)

Identifying the Brain-Tumour Interface Identifying the Brain-Tumour Interface

Identification of IDH mutations Identification of IDH mutations

Conclusions • • Accurate, real-time, label free molecular tissue imaging during surgery is a Conclusions • • Accurate, real-time, label free molecular tissue imaging during surgery is a reality: a number of challenges need to be overcome The technology provides information to ensure the maximum extent of resection is obtained Further trial required to investigate individual surgeon learning curves, comparison with other standards (IDEAL 3) The future: such advances are the beginning of an exciting journey shifting Neurosurgery from organ level precision to cellular level precision