Non-Invasive Early Detection of Lung Cancer (LCD) by Cytogenetic Biomarker in Sputum Dekel Shlomi 1, Alon Ben-Nun 4, Tal Kaplan 7 , Maya Ilouzeb 3, David Simanski 4, , Tiberiu Shulimzon 5, Naomi Gai-Mor 3, Lahav Cohen 7, Nir Golan 4, Erik Baltaxe 5, Jair Bar 6, Amir Onn 5, 6 and Nir Peled 2, 3 1 Clalit Health Services, Dan Petah-Tikva District, 2 Thoracic Cancer Unit, Davidoff Cancer Center, Rabin Medical Center, 3 Thoracic Cancer Research and Detection Center, Sheba Medical Center, Tel-Aviv University, 4 Department of Thoracic Surgery, Sheba Medical Center , 5 Institute of Pulmonary Diseases, Sheba Medical Center, 6 Thoracic Oncology Unit, Sheba Medical Center, 7 Bio. View Ltd, Rehovot, Israel. Introduction • Lung cancer is the leading cause of cancer death. • Early detection and treatment of lung cancer (LC) is the most important factor to decrease mortality. • A target-FISH Lung Cancer Detection (LCD) test developed by Bio. View Ltd, under a license from MD Anderson Cancer Center, as a noninvasive diagnostic assay based on combine analysis of cytology and cytogenetic biomarkers of bronchial epithelial cells present in sputum. Methods Results • Induced sputum samples were collected from subjects with 0. 8 -3 cm solitary pulmonary nodule who were scheduled for a lung biopsy procedure. • The Target FISH LCD Test integrates the expression of specific cytogenetic biomarker within a selected population of exfoliated respiratory cells in induced sputum with the imaging capabilities of the Bio. View Duet™ System which enables to examine the same cell twice. • Objective: To evaluated the performance of the LCD test for detection of numeric alterations at the 3 p 22. 1 and 10 q 22. 3 loci via fluorescence in situ hybridization (FISH) in induced sputum specimens in patients with pulmonary nodules suspected of having lung cancer. Conclusions: • • Suspicious lung nodules can be evaluated non-invasively by a new sensitive test of induces sputum that combines morphology detection and FISH analysis. We recommend the LCD test as an aiding tool in the management of solitary pulmonary nodule.
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