Modeling Platform for Collaboration Zheng Li
TERANODE Modeling Platform • TERANODE Design Suite – Biological Modeler – Protocol Player – Closed-loop Edition – Starter Edition (free) • TERANODE Model Server • SDK 2
Teranode History 2005 Q 1 Q 4 2004 V 2 Launch (Oct) “ Top 100 Innovators” award Q 3 Q 2 V 2. 5 Launch (Jan) First Production Sites Q 1 Closed Series A Production Clients V 1 Released (Feb) Q 4 2003 Q 3 Signed First Pilot Customer Q 2 Q 1 Q 4 NIH Grant Awarded ($1. 8 M over 3 yrs) 3 Teranode Patents Pending Technology Transfer Complete Q 3 Incorporated in Seattle, WA (June) DARPA, NSF, NIH, Intel research funding 3
The Challenge • Closed-loop R&D requires • flexibility and Scalability Flexibility Documents Desktop apps Scalability Existing options force users and managers to choose 4 Databases Custom apps
Our Approach Modeling provides both 5
Informatics Choices: Databases, Documents, and Models SCALE Millions of Data Points LIMS/Databases Models Expensive Programming Long Deployment Cycles Poor Data Mobility Programming-free Common Data Platform Data Mobility Cost-effective Documents Error-prone Time-consuming Limited Reuse 1, 000’s of Data Points Dynamic Static DATA REQUIREMENTS 6
TERANODE Offering TERANODE Solutions Pathway Analytics Reagent Production Sample Management TERANODE Design Suite Analytics Lab Equipment and Systems System Biology Repositories TERANODE Model Server 7
Data Bottlenecks with Current LIMS Bottleneck Impact Fragmentation Data Must Be Imported and Exported Between Multiple Systems and Applications Programming Delayed Results Slow and Costly Development Changing Data Requirements of Protocols Requires Programming Centralization Limited Collaboration Data Access and Sharing Requires Database Connection Rigidity Siloed Systems Required Schema Standardization Limits Broad Deployments 8
Model-Driven LIMS with Teranode Solution Benefit Protocol Models Real-Time Decision Support Automation of Data Management, Integration, and Analytics Protocol Modeler Visual Protocol Designs by Scientists Captured as Models Protocol Player Rapid Development Common Platform Design Independent Automation VLX Portable Data Format Enabling Data Mobility for Collaboration and Integration 9 Anywhere Data Usage
TERANODE Solution Screening Automation • TERANODE Screening Automation – TERANODE Design Suite – TERANODE Model Server – Screening Models – Integration Libraries • Benefit – Flexible assay design – Data automation – Real-time decision support – No programming required 10
Flexible Assay Design Challenge Develop a protein array solution that supports changing assay parameters and automates statistical and regression analysis Solution • TERANODE Design Suite • Custom regression analysis tool Results • • Deployed solution in 7 days Provided unlimited assay design flexibility Automated statistical & regression analysis Enhanced project team collaboration 11
Data Automation Challenge Develop a chemical screening solution that automates data processing and IC 50 determinations Solution • TERANODE Design Suite & Model Server • MD Spectramax data importer tool • Data dictionary Results • • Deployed solution in 5 days Automated data processing and analysis Eliminated data processing errors Provided real-time assay results 12
Model-Driven Informatics: VLX Models Data Services Data Flow, Storage, and Indexing Computation Services Analytics and Simulations Integration Services Interchange with Equipment and External Systems Compliance Services Audit Trail and Reporting VLX Model 13
Versatility of TERANODE Platform Pathway Analytics Study Design Target Id. Diagnostics Assay Design Process Science Hit Triage HTS Reagent Prod. 14 Sample Mgmt.
Demo 15
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