Micro- and Nanoencapsulation Laboratory St. Petersburg State Polytechnic University Gleb Sukhorukov /Queen Mary University of London, United Kingdom/
Technology of Layer –by-Layer encapsulation (Max Planck Institute of Colloids and Interfaces) - >25 groups working in area of Lb. L encapsulations in Europe, USA, China, Japan, Singapore, Australia and worldwide - ~ 3, 000 publications over 10 years - Reserach impact (high citation numbers) - Versatile applications (Biomedical, Pharma, Cosmetic, Food, Materials) - Strong industrial interest (Bayer AG, BASF, L‘Oreal, Nestle. . . ) - Spin-off company Capsulution AG
Multifunctionality to Microcapsules (50 nm – 50 mkm) Microreactors Macromolecule encapsulation Visualization, Sensors A+B C Protection Cell-/Tissue. Targeting Controlled release Remote activation Magnetism Most of activities are in: - Novel Phys/Chem properties; - Deliver systems; - Cell biology tool
Delivering/Sensing Submarine Floating in body Submarine External triggering / reporting inside cells/tissues
Perspective Research Activities at SPb. SPU - Bio. Medical & Bio. Physics Single-cell biopsy/ Cell-to Cell communication n Capsule-Surface interactions n Fabrication of Release control over depot-systems n In vivo studies for encapsulated drugs delivery n and more… n
Single-cell biopsy / Cell-to-Cell Communication Capturing molecules intracellularly and delivery to other cells – artificial exosomes exchange Available expertise: Mass-Spec, Cell facilities Collaboration: Prof. M. Khodorkovskii Dr. Irina Nazarenko (Freiburg), Dr. Arkady Shipuline
Capsule – Surface Interaction - One of major problems of Lb. L microencapsulation technology – aggregation and sticking to cell membranes when used in vivo. Some coatings (PLL-g-PEG, Dextran) are proposed to cope with the problem, but are not absolute solution. Study adhesion aiming to optimize selectivity to cell surface Optical tweezers technique (M. Khodorkovski’s group) to measure interaction forces.
Fabrication and Release control of depot-systems Fabrication and controlled gradual release from microcapsules and its assemblies as a depot-system. Monitoring on cell culture/ Tissue scaffolds . Modelling of Release kinetics
Animal Testing and More…… Partner for sample testing St. Petersburg Institute of Vaccines and Sera Russian Ministry of Health We open for New Ideas on Other Areas!
Outlook / Key Performance Indicators In 2 -3 years time: - 3 -4 academic staff/postdocs, Ph. D students, master students Publications (IF>3): - 1 -2 (2015), 3 -4 (2016, 2017. . . and beyond) Indusrial contracts and/or joint research grant (1 -2 per year) Research grants (RSF, . . EU, International) – 1 per year from 2016
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