Macrophage Activation by Heparanase Is Mediated by TLR 2 and TLR-4 and Associates With Plaque Progression by Miry Blich, Amnon Golan, Gil Arvatz, Anat Sebbag, Itay Shafat, Edmond Sabo, Victoria Cohen-Kaplan, Sirouch Petcherski, Shani Avniel-Polak, Amnon Eitan, Haim Hammerman, Doron Aronson, Elena Axelman, Neta Ilan, Gabriel Nussbaum, and Israel Vlodavsky Arterioscler Thromb Vasc Biol Volume 33(2): e 56 -e 65 January 16, 2013 Copyright © American Heart Association, Inc. All rights reserved.
Increased cytokine levels after heparanase addition. Miry Blich et al. Arterioscler Thromb Vasc Biol. 2013; 33: e 56 -e 65 Copyright © American Heart Association, Inc. All rights reserved.
Elevation of cytokine levels by heparanase does not require heparan sulfate (HS)-degrading activity and involves increased gene transcription. Miry Blich et al. Arterioscler Thromb Vasc Biol. 2013; 33: e 56 -e 65 Copyright © American Heart Association, Inc. All rights reserved.
Mitogen-activated protein kinase and phosphatidylinositol-3 kinase signaling pathways mediate cytokine elevation by heparanase. Miry Blich et al. Arterioscler Thromb Vasc Biol. 2013; 33: e 56 -e 65 Copyright © American Heart Association, Inc. All rights reserved.
Cytokine induction by heparanase is mediated by nuclear factor-κB (NFκB), Toll-like receptor (TLR)-2, and TLR-4. Miry Blich et al. Arterioscler Thromb Vasc Biol. 2013; 33: e 56 -e 65 Copyright © American Heart Association, Inc. All rights reserved.
Clinical relevance. Miry Blich et al. Arterioscler Thromb Vasc Biol. 2013; 33: e 56 -e 65 Copyright © American Heart Association, Inc. All rights reserved.
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