Investigation of allergic sensitisation in areas of Hungary

Investigation of allergic sensitisation in areas of Hungary with different level of ragweed pollution Páldy A 1 Bobvos J 1. , Nékám K 2. , Bitay Zs 3. , Csajbók V 4. , Kelemen A 5. , Major T 6. 1 National Institute of Environmental Health, 2 Hospital of Brothers of Mercy, Budapest, 3 Bács-Kiskun County Dispensary Kecskemét, 4 Józsa András Hospital, Nyíregyháza, Szabolcs-Szatmár Bereg County 5 Heves County Dispnesary Eger, 6 HRCh Hospital of Cardio-pulmonary patients Mosdós

Aim n To investigate the pattern of sensitisation of allergic patients in areas with different level of ragweed pollution n Sampling sites and patients: n Kecskemét, Nyíregyháza, Eger n n n 50 -50 adult allergic patients Mosdós: 22 allergic patients Study: questionnaire survey n Specific Ig. E measurement by using a common panel

Examined allergens in children and adult population with symptoms of allergy, Hungary, 2006

Results Evaluation of the questionnaire n Description of sensitisation n Demonstration of the association of ragweed sensitisation and answers to the questions n

Distribution of answers to the questionnaire I. In Eger and Kecskemét the rate of breast fed patients was higher In Eger and Nyíregyháza the rate of complaints due to feather allergy was high The rate of smokers and rate of mould in flats was the highest in Kecskemét

Distribution of answers to the questionnaire II. The leading complaints are housedust mite and pollen allergy – highest in Eger, Allergic skin symptoms and pet allergy – highest in Kecskemét.

Distribution of polysensitisation acc. to the questionnaire Rate of polysensitized patients -highest in Eger, lowest in Nyiregyhaza

Animal hair allergy Cow hair allergy was reported in Mosdós and Kecskemét Rate of patients reporting dog hair allergy is high in each site

Type of house and allergic complains In Mosdós, majority of patients live in family houses, In Eger and Nyíregyháza the majority of them live in housing district (panel building). The type of house does not affect the allergic complaints. House dust mite allergy is the most frequent in block houses, drug allergy and skin symptoms – in family houses, pet hair – in panel buildings.

Allergic symptoms and breast feeding Multiallergic symptoms are less frequent among non breast fed patients. Rate of pollen and mite alleric symptoms are less frequent among breast fed patients.

Percentage of sensitisation in the total sample X X X x

The most frequently detectable outdoor allergen Ig. Es by sites

The most frequently detectable food allergen and animal Ig. E levels (%) by sites

Prevalence of pollen and dust mite allergy complaints in relation to ragweed sensitised patients In Eger and Kecskemét complaints do not correlate with ragweed Ig. E positivity In general 33% of patients have Ig. E against house dust mite - in more than 50% in Nyíregyháza.

Detectable anti - ragweed Ig. E in breast fed and smoking patients In Kecskemét and in Nyíregyháza rate of ragweed Ig. E pozitivity is higher among non breast fed patients. In Kecskemét rate of smoking patients is higher among ragweed positive patients

The project was founded by: National Research and Development Program socio-health research NKFP -1 B/022/04. 2005 -2006