Introduction Biochemize S. L. is a biotechnological company focused in the design and development of processes based on biocatalysis. Our technological platform lies in the use of enzymes or microorganisms to perform chemical reactions able to substitute manufacturing processes based on classical organic chemistry.
Location We are located in Terrassa, at 20 km from Barcelona. Our office and laboratories are part of the facilities of the Technology Centre of our associate partner Leitat.
Our Technology Biochemize S. L. develops bioprocesses using biocatalysts (enzymes or microorganisms) in single or multiple transformation steps. Our technological platform P 2 B (Platform to Biochemize) is capable to perform high throughput screening of biocatalysts, reaction conditions, suitable substrates and products obtained. The screening can be done in a short period of time and renders information about different possible bioprocesses and conditions that could be further developed at a larger scale.
P 2 B – Platform To Biochemize P 2 B is the key to determine quickly with low risk and at very small scale if a conceptual biotransformation is technologically viable. Once the succeeding biocatalysts or bioprocesses have been identified, Biochemize S. L. investigates at lab scale the experimental conditions which can lead to the highest yields. Two approaches can be followed: P 2 B Bioprocess Development of bioprocesses suitable to substitute already established synthetic procedures up to an industrial scale P 2 B Discovery Perform biotransformations that can lead to a (new) chemical entity with improved features compared to the starting molecule
P 2 B – Discovery P 2 B Discovery is an ideal approach for molecules with a complex structure or different functional groups that can be affected when trying to modify them by synthetic procedures. Biocatalysts can be used to obtain new lead, lead optimization, me-too and me-better compounds by modification of already available structures.
P 2 B – Discovery The biotransformation can be: Directed The type of transformation is selected based on the functional group or structure targeted. This approach is suitable when it is well known what feature is conferred by the new functional group or structure in the final molecule (e. g. make it more soluble) Exploratory The transformations applicable are diverse in order To test what kind of molecules can be obtained from a given starting structure or what kind of final properties may be achieved. This approach is appropriate to seek new development opportunities (e. g. improved or different pharmacological properties)
P 2 B – Discovery Biotransformations Oxidations / Reductions Hydration / Dehydration Glycosilations Sulfidations / Sulfoxidations Aromatic Chlorination N-, O-, S-methylation Nitrilation Alkylation / Dealkylation Amide and Ester formation / hydrolysis Potentially, any biotransformation already described…
Applications of P 2 B – Discovery Evaluation of pharmacological properties Improve the solubility Source of building blocks Obtain more stable molecules Increase the IP of the company or the pipeline of products Support in Analytical Methods development More…
Project Management in P 2 B – Discovery The P 2 B Discovery process consists of the following phases: Bibliography Assessment PHASE I Biotransform. Screening Biocatalyst Selection & Reproduction Compound Characteriz. PHASE III PHASE IV Small Scale Production Tests of Properties by Customer PHASE V q Flexible: Phases can be omitted, merged, delimited or adapted to each project or customer requirements. q Step-wise: Each phase is not planned nor quoted until the previous phase is completed and the results presented. q Risk-Control: The customer decides the project continuation at each phase depending on results and conclusions obtained so far. q Fast: The objective is to provide small amounts of promising (new) molecules in a short time, avoiding setting-up long, difficult and low yield synthetic procedures. q Results oriented: The customer is able to decide if full development is a business opportunity according to the properties tests of molecules provided.
Operations Biochemize S. L. offers the most outstanding and up to date technology options, while maintaining an industrial scope. If necessary, many operations can be outsourced to other companies and research centres under our direction and supervision. We have a powerful network of contacts in biocatalysis and bioprocessing. Several partnership agreements have been established. Advisors Analytical Services Biocatalyst Suppliers Bioprocessing Services Biotransformation Experts Enzyme Screening Enzyme Immobilization Genetic Engineering Manufacturers Research & Development Scaling-Up Services Austria Bulgaria China Denmark Ireland Italy Korea Netherlands Spain United Kingdom United States
Why contracting Biochemize? We offer the most outstanding and up to date technology options. Industrial scope guaranteed: productivity, costs and risks are the key drivers of our evaluations. Our technology platform (P 2 B) is a powerful tool for fast, low risk and P 2 B small scale proof of concept verifications. We increase the success possibilities through the P 2 B platform and our network of contacts. Project management based on a development by phases approach. The customer controls the risks and costs associated to the project development.
Contact Jaume Mir Founder CEO and Commercial Director E-mail: jmir@biochemize. com Telephone: ++34 686 441 120 Address: C/. de la Innovació, 2 (Leitat Centre Tecnològic) 88225 – Terrassa (Barcelona) SPAIN
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