Institutional Animal Care and Use Committee IACUC The

Institutional Animal Care and Use Committee (IACUC) The IACUC provides internal oversight of animal: - husbandry - facilities - use in teaching & research The ASU IACUC consists of 11 voting members plus other supporting participants who include: - faculty representing the various departments and uses of animals - representatives of relevant ASU service departments - DACT (including the Attending Veterinarian) - EH&S - Campus Health - VPREA Office - Risk Management - non-affiliated member

Institutional Animal Care and Use Committee (IACUC) Web site includes: - Policy and Procedure Manual - forms - training instructions and exams - Occupational Health & Safety Program documents - Standard Institutional Guidelines - protocol due dates & meeting dates - Animal Welfare Assurance & USDA certificate numbers - society non-traditional species guidelines - AVMA euthanasia guidelines - federal regulations - etc. http: //researchintegrity. asu. edu/animals iacuc

Institutional Animal Care and Use Committee (IACUC) Last year’s 2 aims as the new Chair: 1) To assure that ASU meets all regulatory requirements - USDA – enforces the Animal Welfare Act. Definition of “animal”? All mammals except laboratory mice & rats October 28 -29, 2009 - OLAW (Office of Laboratory Animal Welfare) – oversees the use of non -human vertebrates in PHS-supported research (PHS Policy on Humane Care and Use of Laboratory Animals, 2002) - AAALACi (Association for the Assessment & Accreditation of Laboratory Animal Care International) – voluntary, covers all non-human vertebrates at the institution March 5 -6, 2009 - U. S. Fish & Wildlife Service – oversees federally protected species and international transport of all vertebrate animals and their parts - Arizona Game & Fish Department – oversees the capture & holding of native wildlife, as well as the holding of restricted non-native wildlife - Arizona Department of Health Services – covers species where there is a concern for zoonotic disease

Institutional Animal Care and Use Committee (IACUC) Last year’s 2 aims as the new Chair: 2) To minimize the burden on investigators (provided it does not interfere with Aim 1) - Require IACUC training and certification specific to the investigator, not the protocol. - Eliminate the need for duplicative protocols in situations where a PI conducts work at multiple local institutions. ASU-BNI agreement - ? ? Species with which individual will have direct contact (“all” or list species)* Name Title Role in Protocol (What procedures will each person be doing? ) Dale De. Nardo Associate Professor PI, no procedures none Joe Shmoe Graduate Student all rats, mice IACUC USE ONLY Training (mm/yy)

Institutional Animal Care and Use Committee (IACUC) The review process (details in the Policy & Procedure Manual): Protocols: - pre-reviewed by the Attending Veterinarian, then one other IACUC member (assigned by the Chair as the Primary Reviewer) - reviewed by the full committee at a convened meeting in the presence of the PI or designee Amendments: - Minor – administratively approved by the Chair - a change that does approval of effect the animals - Significant – with thenot in any waythe full committee, reviewed by a Designated Reviewer (assigned by the Chair) and the Attending Veterinarian - – rationale by full committee at a convened - Major thereviewed for the new procedure is consistent with the research goals in the approved protocol meeting - involves no increased risk of pain, distress, or discomfort to animals - does not markedly increase, by absolute or relative terms, the number of animals involved in the project

Changes to the Protocol Form Why were there changes? - section for Additional Contact information - split the literature search into two separate searches - duplicative research - alternatives to animal use and painful procedures - includes section to summarize results - pay close attention to the search words used - method of animal identification, if any Regulatory oversight is very dynamic, expect more changes! - qualifications and training of all participants (in protocols and added in an amendment) MAKE SURE TO USE THE MOST CURRENT FORM! (available on the web site)