Increased Brain Expression of Matrix Metalloproteinase-9 After Ischemic and Hemorrhagic Human Stroke by Anna Rosell, Arantxa Ortega-Aznar, José Alvarez-Sabín, Israel Fernández. Cadenas, Marc Ribó, Carlos A. Molina, Eng H. Lo, and Joan Montaner Stroke Volume 37(6): 1399 -1406 June 1, 2006 Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. A and B, Zymograms corresponding to 3 representative ischemic and 1 hemorrhagic patients. Anna Rosell et al. Stroke. 2006; 37: 1399 -1406 Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Gelatinase expression after hemorrhagic transformation: computed tomography image, fresh brain tissue sample displaying HT and corresponding in situ zymography (magnification 100 x) and gelatin zymography showing greater MMP-9 signal in HT than in infarct and peri-infarct. Anna Rosell et al. Stroke. 2006; 37: 1399 -1406 Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. A, A strong correlation was found (r=0. 912, P<0. 0001) between pro-MMP-9 and 145 k. Da bands. Anna Rosell et al. Stroke. 2006; 37: 1399 -1406 Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. MMP-9 immunohistochemistry: brown immunoreactivity in infarcted tissue (A and B) surrounding the endothelial/ periendothelial layer associated to neutrophils infiltration (arrowheads in B and C). Anna Rosell et al. Stroke. 2006; 37: 1399 -1406 Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. In situ zymographies: A through C are representative zymograms from an ischemic stroke (A: infarct; B: peri-infarct; C: ischemic contralateral); D and E, representative zymograms from a hemorrhagic stroke (D: perihematoma, and E: hemorrhagic contralateral); F, control. Anna Rosell et al. Stroke. 2006; 37: 1399 -1406 Copyright © American Heart Association, Inc. All rights reserved.
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