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Improving Performance in Practice (IPIP) Change Package Coaching Practices Improving Healthcare State by State Improving Performance in Practice (IPIP) Change Package Coaching Practices Improving Healthcare State by State Martha Rome, RN, MPH Milwaukee, WI February 11, 2009 1

Aims of IPIP • To dramatically improve patient outcomes by transforming the way we Aims of IPIP • To dramatically improve patient outcomes by transforming the way we deliver primary care, focusing initially on measurable improvement in diabetes and asthma, but rapidly spreading to preventive services and other conditions • To assist different types of practices in using practice redesign strategies to improve efficiency and implement best practices • To align efforts and motivate action at the national, regional, state, practice and patient level 2

Aligning Across Policy Levels National State Network Practice Patient 3 Aligning Across Policy Levels National State Network Practice Patient 3

Build will on state level and create state infrastructure • National specialty societies work Build will on state level and create state infrastructure • National specialty societies work through state chapters • Specialty Boards provide clear expectations for maintenance of certification • Partner with other organizations in the state – AHEC, QIO, payers, businesses, state government • Aligning state efforts creates the IPIP model • National Team supports states with: – – – Standard protocols Decision support tools Access to other practices who’ve done this work successfully Access to experts in the field Data aggregation and reports 4

Model • Improvement networks/collaboratives • Quality Improvement Coaches: Support individual practices and improvement networks Model • Improvement networks/collaboratives • Quality Improvement Coaches: Support individual practices and improvement networks – Onsite consulting – Group meetings (in person and phone) • Reporting: monthly submission of performance measures 5

Schematic of IPIP Process QIC Enroll in IPIP Statewide primary Care practices Documentation of Schematic of IPIP Process QIC Enroll in IPIP Statewide primary Care practices Documentation of knowledge and performance Activated physician Starting point for QI Collaborative practice Using shared data Knowledge Management Improved outcomes with physicians and practices expert in QI 6

Role of Quality Improvement Coaches • Intensive (often) on-site work with the practice team Role of Quality Improvement Coaches • Intensive (often) on-site work with the practice team • Provide avenue to network activities and share best practices • Focused approach for implementation starting with key process changes – Move practices faster for basic implementation – Create group momentum with regard to implementation and standardization • Help practices ensure that all IPIP changes are implemented • Assist practices in developing teams & standardized work flow • Provide examples of tools (standing orders) and roles • Assist practices with regular monitoring of 7 implementation to ensure reliability

Living with chronic illness is like piloting a small plane 8 Living with chronic illness is like piloting a small plane 8

To get safely to their destination pilots need: • Flight instruction • Preventive Maintenance To get safely to their destination pilots need: • Flight instruction • Preventive Maintenance • Safe Flight Plan • Air Traffic Control Surveillance • Self-Management Support • Effective Clinical Management • Treatment Plan • Close Follow-up 9

Usual care works well if your plane is about to crash 10 Usual care works well if your plane is about to crash 10

The IOM Quality Report: Selected Quotes • “The current care systems cannot do the The IOM Quality Report: Selected Quotes • “The current care systems cannot do the job. ” • “Trying harder will not work. ” • “Changing care systems will. ” 11

The Watchword Systems are perfectly designed to get the results they achieve 12 The Watchword Systems are perfectly designed to get the results they achieve 12

A Recipe for Improving Outcomes Evidence-based Clinical Change Concepts System change strategy System Change A Recipe for Improving Outcomes Evidence-based Clinical Change Concepts System change strategy System Change Concepts Learning Model 13

Advantages of a General System Change Model • Applicable to most preventive and chronic Advantages of a General System Change Model • Applicable to most preventive and chronic care issues • Once system changes in place, accommodating new guideline or innovation much easier • Early participants in our collaboratives using it comprehensively 14

Essential Element of Good Chronic Illness Care Informed, Activated Patient Productive Interactions Prepared Practice Essential Element of Good Chronic Illness Care Informed, Activated Patient Productive Interactions Prepared Practice Team 15

What characterizes a “prepared” practice team? Prepared Practice Team At the time of the What characterizes a “prepared” practice team? Prepared Practice Team At the time of the visit, they have the patient information, decision support, people, equipment, and time required to deliver evidence-based clinical management and self-management support 16

What characterizes a “informed, activated” patient? Informed, Activated Patient understands the disease process, and What characterizes a “informed, activated” patient? Informed, Activated Patient understands the disease process, and realizes his/her role as the daily self manager. Family and caregivers are engaged in the patient’s self-management. The provider is viewed as a guide on the side, not the sage on the stage! 17

How would I recognize a productive interaction? Informed, Activated Patient Productive Interactions Prepared Practice How would I recognize a productive interaction? Informed, Activated Patient Productive Interactions Prepared Practice Team • Assessment of self-management skills and confidence as well as clinical status • Tailoring of clinical management by stepped protocol • Collaborative goal-setting and problem-solving resulting in a shared care plan • Active, sustained follow-up 18

Chronic Care Model Community Health System Health Care Organization Resources and Policies Self. Management Chronic Care Model Community Health System Health Care Organization Resources and Policies Self. Management Support Informed, Activated Patient Delivery System Design Productive Interactions Decision Support Clinical Information Systems Prepared, Proactive Practice Team Improved Outcomes 19

Clinical Information System • Provide reminders for providers and patients. • Identify relevant patient Clinical Information System • Provide reminders for providers and patients. • Identify relevant patient subpopulations for proactive care. • Facilitate individual patient care planning. • Share information with providers and patients. • Monitor performance of team and system. 20

Delivery System Design • Define roles and distribute tasks amongst team members. • Use Delivery System Design • Define roles and distribute tasks amongst team members. • Use planned interactions to support evidencebased care. • Provide clinical case management services. • Ensure regular follow-up. • Give care that patients understand that fits their culture 21

Self-management Support • Emphasize the patient's central role. • Use effective self-management support strategies Self-management Support • Emphasize the patient's central role. • Use effective self-management support strategies that include assessment, goalsetting, action planning, problem-solving and follow-up. • Organize resources to provide support 22

To Change Outcomes (e. g. , Hb. A 1 c) Requires Fundamental Practice Change To Change Outcomes (e. g. , Hb. A 1 c) Requires Fundamental Practice Change • Interventions focused on guidelines, feedback, and role changes can improve processes • Interventions that address more than one area have more impact • Interventions that are patientcentered change outcomes. Renders et al, Diabetes Care, 2001; 24: 1821 23

Templates Related to Better Performance and Less Variation (IPIP practices) 24 Templates Related to Better Performance and Less Variation (IPIP practices) 24

IPIP Change Package • High-leverage Changes – Implement Registry – Use Template for Planned IPIP Change Package • High-leverage Changes – Implement Registry – Use Template for Planned Care – Use Protocols – Adopt Self-management Support Strategies 25

Implement IPIP Changes in Steps 1. Use Registry to identify asthmatics/diabetics prior to visit Implement IPIP Changes in Steps 1. Use Registry to identify asthmatics/diabetics prior to visit (this requires the work of implementing a registry or “fixing” the EHR) Use condition-specific decision support tool (e. g. , visit planner) Create customized flow diagram and protocols to standardize the care process 2. 3. • • • 4. Nursing Standing Orders to increase reliable execution [examples] Standard Protocol [example] Specific Care Team roles: who does what in the protocol Implement a self-management support system Throughout: Frequent monitoring of reliability and investigation of failures for ideas about how to improve standard performance 26

Detailed Changes: Registry 1) Select and install a registry tool 2) Determine staff workflow Detailed Changes: Registry 1) Select and install a registry tool 2) Determine staff workflow to support registry use 3) Populate registry with patient data 4) Routinely maintain registry data 5) Use registry to manage patient care and support population management 27

Detailed Changes: Templates 1) Select template tool from registry or create a flow sheet Detailed Changes: Templates 1) Select template tool from registry or create a flow sheet 2) Determine staff workflow to support use of template 3) Use template with all patients 4) Ensure registry updated each time template used 5) Monitor use of template 28

Detailed Changes: Protocols Step 3: Use Protocols a. Select and customize evidence-based protocols to Detailed Changes: Protocols Step 3: Use Protocols a. Select and customize evidence-based protocols to office b. Determine staff workflow to support protocols, including standing orders c. Use protocols with all patients d. Monitor use of protocols 29

Protocols: Asthma-specific • Assess and document asthma severity and control • Prescribe appropriate asthma Protocols: Asthma-specific • Assess and document asthma severity and control • Prescribe appropriate asthma medications and monitor overuse of beta agonists • Use Asthma Management plans • Establish visit frequency protocol • Assess and treat co-morbidities • Assess, counsel, and prevent exposure to environmental triggers 30

Protocols: Diabetes Check and treat BP <130/80 Check and treat cholesterol Check A 1 Protocols: Diabetes Check and treat BP <130/80 Check and treat cholesterol Check A 1 C and treat hyperglycemia Assess aspirin and prescribe if not using Assess need for eye exam and make referral if needed • Assess nephropathy risk • Perform foot exam • Provide appropriate vaccines • • • 31

Self-management Support • Obtain patient education materials (e. g. , asthma action plans) • Self-management Support • Obtain patient education materials (e. g. , asthma action plans) • Determine staff workflow to support SMS • Provide training to staff in SMS techniques • Set patient goals collaboratively • Document and monitor patient progress toward goals • Link with community resources (schools, service organizations) 32

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Cincinnati Children’s Hospital PHO • 44 geographically dispersed, sites • Individual models and styles Cincinnati Children’s Hospital PHO • 44 geographically dispersed, sites • Individual models and styles of practice • “First Wins” – Early adoption of registry – Concurrent data collection: written parent symptom review and clinical interview 34

BMF Included PHO practices achieve > 80% reliability (“perfect care”) 35 BMF Included PHO practices achieve > 80% reliability (“perfect care”) 35

Relationship between changing process and changing outcome 80% of Patients Receive “Perfect Care” 36 Relationship between changing process and changing outcome 80% of Patients Receive “Perfect Care” 36

Impact of PHO Asthma Initiative 37 Impact of PHO Asthma Initiative 37

UNITE HERE Health Center l Founded 1914 by ILGWU l Union mergers over the UNITE HERE Health Center l Founded 1914 by ILGWU l Union mergers over the years, now UNITE HERE l Comprehensive Primary and Specialty Care Serves predominantly UNITE HERE members, their families and retirees and SEIU 32 BJ members l l 1000 office visits/week l 12 PCP’s, 40 specialists, all staff bilingual On Site Physical Therapy, Radiology and Pharmacy l 38

Primary Care Teams l High functioning multidisciplinary teams with 2 hours protected meeting time Primary Care Teams l High functioning multidisciplinary teams with 2 hours protected meeting time every other week l Huddles –Led by MA who does chart reviews day before –First 20 minute appointment blocked –Identify patients for health coach interventions l Cell phones and walkie-talkies Protocols developed & incorporated into EMR templates l 39

Teamwork • PCAs trained in monofilament testing, glucose diaries and ABC cards • Standing Teamwork • PCAs trained in monofilament testing, glucose diaries and ABC cards • Standing orders for Pneumovax and ophthalmology appointments • Pharmacy gets A 1 C lists for medication review • Health Coaches for DM education, self management goal setting, BP checks and blood glucose checks 40

Transforming Medical Assistants into Health Coaches l Curriculum developed for in-house training l Didactic Transforming Medical Assistants into Health Coaches l Curriculum developed for in-house training l Didactic and observational testing Promotion to “Health Coach” after competency evaluation l Supervision by Nurse Practitioner and RN coordinator l 41

Evidence Based Care • All providers use the DM template • Review and discussion Evidence Based Care • All providers use the DM template • Review and discussion of data at provider meetings • DM always on the agenda • Provider educational seminars • Provider chart reviews 42

Challenges 43 Challenges 43

Focus on Hypertension • Reinforced • • use of BP check visit – patient Focus on Hypertension • Reinforced • • use of BP check visit – patient sees RN or Health Coach New protocol and training for MA to recheck BP if high prior to seeing PCP BP Loan Program Chart Reviews Discussion with PCPs at monthly meeting 44

CHART REVIEW FOR UNCONTROLLED HYPERTENSION IN PEOPLE WITH DIABETES Number of patients: 122 BP CHART REVIEW FOR UNCONTROLLED HYPERTENSION IN PEOPLE WITH DIABETES Number of patients: 122 BP at last PCP visit: <140/90 72 (59%) >140/90 50 (41%) Was BP rechecked after first reading: Yes 37 (30%) No 86 (70%) Number of medications for HTN: 0 - 14 (11%) 1 - 28 (23%) 2 - 34 (28%) 3 - 26 (21%) 4 - 13 (11%) >4 - 6 (5%) 2 or fewer 76 (62%) 3 or fewer 102 (84%) Was uncontrolled HTN identified as a problem: Yes 82 (67%) No 40 (33%) Took medications for HTN on day of visit: Yes 33 (27%) No 24 (20%) Not in note 51 ( 42%) N/A 8 (7%) 45

PCP Discussions • Monthly PCP meetings • Results of chart reviews drive PCP • PCP Discussions • Monthly PCP meetings • Results of chart reviews drive PCP • • • discussion Discuss clinical management of HTN Ask PCP with best results – what do you do? Share best practices - start with combination drugs 46

PCP Discussions • Identifies common misconceptions – • “uncontrolled patients are already on maximal PCP Discussions • Identifies common misconceptions – • “uncontrolled patients are already on maximal doses of medications” Identifies target for improvement – importance of rechecking BP if uncontrolled and asking if patients took their medications on the day of the visit 47

The Multidisciplinary Team: The key to successful planned diabetes care and quality improvement in The Multidisciplinary Team: The key to successful planned diabetes care and quality improvement in our practice Robb Malone, Pharm. D UNC General Internal Medicine January 20, 2009 48

Water cooler discussions Change is scary leadership requires necessary complicated an opportunity Successfulhard change Water cooler discussions Change is scary leadership requires necessary complicated an opportunity Successfulhard change towell designed, active a improve team 49

We assessed root causes and actions Root Causes Actions Continuity of care is poor We assessed root causes and actions Root Causes Actions Continuity of care is poor because providers have limited clinical time Make clinical pharmacists available to patients daily Patients often miss follow-up appointments Call patients to remind them of appointments Transportation barriers can hinder care Increase phone management; 1 -800 number; transportation program Physicians lack time and skill to provide proper diabetes education Pharmacists provide individualized education Patients have low education and literacy Design interventions that do not rely on literacy Physicians contribute to clinical inertia by failing to escalate therapy Need agreement on evidence-based treatment algorithms; Pharmacists use algorithms to escalate therapy with physician sign-off Tracking of patient outcomes is poor Design registry to allow better tracking of 50 patients

Everything tipped in late 2007: How did we hit ‘The Tipping Point’? • “The Everything tipped in late 2007: How did we hit ‘The Tipping Point’? • “The level at which the momentum for change becomes unstoppable. “ • "Ideas and products and messages and behaviors spread like viruses do. “ – The Tipping Point: How Little Things Can Make a Big Difference. Malcolm Gladwell Consensus driven growth that focused on the teamwork, contribution from all, and leadership development in QI Acceptance from the late majority and laggards 51

What did we learn from the first 3 years? • ‘Every system is perfectly What did we learn from the first 3 years? • ‘Every system is perfectly designed to get the results it gets’ • If we don't like the results we have to change the system- basically and radically • Providers responded to data and information at the point of care – Addressed unanswered questions • We must build consensus and standardize • We must diversify • We need to move more quickly 52

An epiphany: The run chart , reporting AVG A 1 c for our clinic An epiphany: The run chart , reporting AVG A 1 c for our clinic 2004 53

Diabetes planned care • Patient registry • Robust decision support • Prompting and stratification Diabetes planned care • Patient registry • Robust decision support • Prompting and stratification of patients by risk – Stepped care approach • • • All patients eligible and recruited for care Patient-centered education Care coordination Expanded standardization and algorithmic care Extensive quality reporting Adoption of the Model for Improvement (MFI) 54

What we learned from 2003 to 2006 • A successful program includes: – A What we learned from 2003 to 2006 • A successful program includes: – A multidisciplinary team – A registry with decision support for proactive care – Consensus backed by evidence-based algorithms and standards • Persistence and leadership are key • Appropriately designed interventions or systems can overcome patient vulnerability • We continually evolve, change is necessary and represents opportunity – Embrace rapid cycle change and the MFI 55

An example of our stepped care approach: Green Zone Stepped-Care Stratification ~ 40% of An example of our stepped care approach: Green Zone Stepped-Care Stratification ~ 40% of our patients Low Risk A patient with any of the following: A 1 C < 7. 5% AND BP < 140/85 AND Global Assessment Good Patient Care Plan All new or recent onset patients are encouraged to attend our group class. 1. CDE visits per request (Medical Intervention). 2. Assistance and care coordination at PCP visit per request only. 3. RD MNT‡ as needed. 4. Passive medication management. 5. Phone follow-up as needed. 6. Toll-Free telephone access and after hours nurse support. 7. Automated lab ordering Continuous Clinical Reassessment 56

An example of our stepped care approach: Yellow Zone ~ 35% of our patients An example of our stepped care approach: Yellow Zone ~ 35% of our patients Stepped-Care Stratification Moderate Risk** A patient with any of the following: A 1 C 7. 5 to 8. 5% AND BP 140 -160/85 -90 AND Global Assessment Fair Patient Care Plan All new or recent onset patients are encouraged to attend our group class. Quarterly CDE visits (Medical Intervention). 1. Intense medication management. 1. If not on ASA, start. 2. If not on Statin, start. 2. Assistance and care coordination at most PCP visits. 3. Target 3 RD MNT‡ visits per year. 4. Phone follow-up as needed. 5. Toll-Free telephone access and after hours nurse support. 6. Automated lab ordering and interpretation Continuous Clinical Reassessment 57

An example of our stepped care approach: Red Zone Stepped-Care Stratification ~ 25% of An example of our stepped care approach: Red Zone Stepped-Care Stratification ~ 25% of our patients High Risk** A patient with any of the following: A 1 C > 8. 5% OR BP > 160/90 OR Global Assessment Poor OR No ASA or Statin Patient Care Plan All new or recent onset patients are encouraged to attend our group class. 1. 2. 3. 4. 5. 6. 7. 8. Bimonthly CDE visits (Medical Intervention). intense medication management. 1. If not on ASA, start. 2. If not on Statin, start. Assistance and care coordination at every PCP visit. Target 3 RD MNT‡ visits per year. Yearly Nutrition class referral. Monthly to biweekly phone follow-up. Toll-Free telephone access and after hours nurse support. Automated lab ordering and interpretation Continuous Clinical Reassessment 58

Role of The Care Assistants • Consists of 4 care assistants • Care assistants Role of The Care Assistants • Consists of 4 care assistants • Care assistants see patients during provider visits – Patient education – Utilize the tools created by the database – Assist the physician – Facilitate proactive care, encourage intervention – Address barriers, adherence, glucose monitoring, provide smoking cessation counseling, screen for depression 59

Average A 1 c in our clinic now 60 Average A 1 c in our clinic now 60

Example 1 Lipid screening & management: A front desk intervention 61 Example 1 Lipid screening & management: A front desk intervention 61

Status of Lipid Management September 2004 • 55% of patients had total cholesterol tested Status of Lipid Management September 2004 • 55% of patients had total cholesterol tested annually • Approximately 68% were prescribed statins • Average total cholesterol = 185 mg/dl • Average LDL = 99 mg/dl • We set a goal that 90% of patients would be screened annually and prescribed a statin 62

Front Desk Process • List of patients with diabetes • Whether or not labs Front Desk Process • List of patients with diabetes • Whether or not labs need to be drawn Plan/Do • We had patients that needed labs that were not getting triaged appropriately Study • Looked at front desk logs and process 63

Front Desk Logs • About 60 patients with diabetes/week • 30 needed a lab Front Desk Logs • About 60 patients with diabetes/week • 30 needed a lab drawn Study • Only 15 had it drawn (50%) 64

Pizza for 90% Fidelity • 25/33 = 75% No pizza • 34/36 = 94% Pizza for 90% Fidelity • 25/33 = 75% No pizza • 34/36 = 94% PIZZA Act-Plan Study 65

Start Automated Re-Start Automated Stop Automated Front desk fidelity 66 Start Automated Re-Start Automated Stop Automated Front desk fidelity 66

Focus on testing and utilization led to improved lipids 67 Focus on testing and utilization led to improved lipids 67

Example 2 Process measure improvement: Nurse-directed interventions, improving the prompts 68 Example 2 Process measure improvement: Nurse-directed interventions, improving the prompts 68

Process to engage nurses • Solidified divisional support for utilization of the intervention • Process to engage nurses • Solidified divisional support for utilization of the intervention • Developed educational session with nurses – Meeting introduction by medical director – Revisited intent of the yellow sheets – Reiterated the role of the nurse as an integral member of our team – Reviewed evidence behind recommendations – Listened to nurses’ concerns • Developed rapid means of feedback 69

Items to be included in nurse assessment • Assess as indicated on the prompt Items to be included in nurse assessment • Assess as indicated on the prompt – Depression screening – Smoking assessment and intervention – Eye referrals – Monofilament testing – Pneumococcal vaccination 70

Modified Intervention (version 3) Feedback and change in clinical focus led to significant revision Modified Intervention (version 3) Feedback and change in clinical focus led to significant revision of the yellow sheets 71

Simple procedure for tracking daily progress- Excel spreadsheet Completed by ancillary staff 72 Simple procedure for tracking daily progress- Excel spreadsheet Completed by ancillary staff 72

Progress with mixed results Bring on the pizza 73 Progress with mixed results Bring on the pizza 73

Widespread, significant improvement noted 74 Widespread, significant improvement noted 74

Provider satisfaction has improved: How has this affected the life of a physician? • Provider satisfaction has improved: How has this affected the life of a physician? • Delegating processes frees up time to focus on diagnostic and therapeutic issues • A weight has been lifted • Excellent to know how the practice performs • Data has changed our conversations • It is satisfying to show improved care 75

Diabetes Improvement Across the Practice--Lessons • Just working harder doesn’t lead to better outcomes Diabetes Improvement Across the Practice--Lessons • Just working harder doesn’t lead to better outcomes • Just making a policy doesn’t mean the process gets done • Doctors in our system don’t follow algorithms or policies very well – Other members of the health care team are better…and that is OK • Each member must function at their highest level of skill • Distractions will arise, challenges will occur 76

In Summary: Change Package • Includes details about making changes, measures, assessment scales and In Summary: Change Package • Includes details about making changes, measures, assessment scales and tools • A resource for practices and QICs • Offers guidance and resources • Remember: Teams’ testing helps adapt and adopt strategies in their office 77

IPIP Expectations • Practices work on redesign of systems of care delivery • Target IPIP Expectations • Practices work on redesign of systems of care delivery • Target improvement in diabetes or asthma • This becomes how we practice healthcare — continuously tracking, sharing, and improving • Participation in IPIP meets one requirement for maintenance of certification and qualifies for Continuing Medical Education (CME) credit 78

Expectations re: Data • Collect data on performance measures (required) • Submit numerators and Expectations re: Data • Collect data on performance measures (required) • Submit numerators and denominators to IPIP via QIC, state program or directly • Reliable, quality care is provided to the entire population by using registry (or EHR with population management functions) 79

What do we mean by data? • Aggregate measures of quality – Based on What do we mean by data? • Aggregate measures of quality – Based on national standards (NCQA, AQA, HEDIS) – Physician or practice-based – Additional details enhance understanding of context and meaning (levels of data quality) – Range of data sources (paper -> Electronic Health Record) 80

Rely Upon Nationally Endorsed Measures • Early in IPIP development, it became clear that Rely Upon Nationally Endorsed Measures • Early in IPIP development, it became clear that the scope of determining “ideal” measures was beyond IPIP • Other organizations exist to do this: NCQA, Physicians Consortium, National Quality Forum, Ambulatory Care Quality Alliance • IPIP decided to only require measures that had been endorsed by a one or more of the above organizations 81

Benefits and Downsides • Mitigates the debate about individual opinions • Dramatically improves our Benefits and Downsides • Mitigates the debate about individual opinions • Dramatically improves our ability to align • Reduces flexibility • Often leaves us with more “clunky” measures (less sensitive to changes) • Measures sometimes change slower than we would like (concerns about obsolete) 82

Required IPIP measures are not the only measures practices should be using Use other Required IPIP measures are not the only measures practices should be using Use other measures to help ensure reliable processes and do small PDSAs 83

 • The complete IPIP Change Package is in Word format on the Extranet. • The complete IPIP Change Package is in Word format on the Extranet. Look under Resources and then in the Change Package folder. 84

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References • www. improvingchroniccare. org • http: //www. med. unc. edu/medicine/general m/documents/Diabetes. Research. pdf References • www. improvingchroniccare. org • http: //www. med. unc. edu/medicine/general m/documents/Diabetes. Research. pdf • www. ihi/org/extranet. 86

 • http: //www. med. unc. edu/medicine/general m/documents/Diabetes. Research. pdf 87 • http: //www. med. unc. edu/medicine/general m/documents/Diabetes. Research. pdf 87