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High-Throughput Microscopy and Computational/Theoretical Challenges in the Analysis of Neural Circuit Structure Society for High-Throughput Microscopy and Computational/Theoretical Challenges in the Analysis of Neural Circuit Structure Society for Neuroscience 2008 Minisymposium Tuesday, November 18, 2008 Room 207 B

“The goal of neural science is to understand the mind, how we perceive, move, “The goal of neural science is to understand the mind, how we perceive, move, think and remember. ” Eric Kandel, James Schwartz, Thomas Jessell, Principles of Neural Science, 4 th Ed.

Santiago Ramón y Cajal • Considered a founder of Neuroscience • Used Golgi staining Santiago Ramón y Cajal • Considered a founder of Neuroscience • Used Golgi staining to study the structure of the central nervous system Sotelo, C. Nature Reviews Neuroscience 4, 7 -77, 2003

We know a great deal about how neurons communicate at the level of the We know a great deal about how neurons communicate at the level of the individual cell and synapse ** http: //morbidanatomy. blogspot. com/2008/0/santiago -ramn-y-cajal-1852 -934. html **http: //www. learner. org/courses/biology/ units/neuro/images. html

Cholinergic synaptic vesicle Kandel et al. , Principles of Neural Science, 4 th Ed. Cholinergic synaptic vesicle Kandel et al. , Principles of Neural Science, 4 th Ed.

We know much less about what happens at the network level Sotelo, C. Nature We know much less about what happens at the network level Sotelo, C. Nature Reviews Neuroscience 4, 7 -77, 2003 http: //www. learner. org/courses/biology/ units/neuro/images. html

http: //www. learner. org/courses/biology/ units/neuro/images. html http: //www. mbl. org/atlas 170_start. html http: //www. learner. org/courses/biology/ units/neuro/images. html http: //www. mbl. org/atlas 170_start. html

This minisymposium will survey the latest advances in high-throughput microscopy methods with the goal This minisymposium will survey the latest advances in high-throughput microscopy methods with the goal of advancing our understanding of brain networks. Imaging and analysis of neuronal microcircuits on the scale of whole small animal brains will be presented. Pertinent computational issues will be discussed.

Speakers n Louise C. Abbott, Texas A&M University Knife-edge scanning microscope (KESM) n Kristina Speakers n Louise C. Abbott, Texas A&M University Knife-edge scanning microscope (KESM) n Kristina D. Micheva, Stanford University Array tomography to probe molecular architecture of neural circuits n Kenneth Hayworth, University of Southern California Use of SEM imaging to create ultrathin section libraries n n n Randal A. Koene, Boston University NETMORPH and automated network reconstruction Ravi Rao, IBM TJ Watson Research Center, NY High-performance computing techniques for neuro-image analysis Yoonsuck Choe, Texas A&M University Fast algorithms for reconstructing cortical neural circuits

SPEAKERS Louise C. Abbott, Texas A&M University Knife-edge scanning microscope (KESM) Kristina D. Micheva, SPEAKERS Louise C. Abbott, Texas A&M University Knife-edge scanning microscope (KESM) Kristina D. Micheva, Stanford University Array tomography to probe molecular architecture of neural circuits Kenneth Hayworth, University of Southern California Use of SEM imaging to create ultrathin section libraries Randal A. Koene, Boston University NETMORPH and automated network reconstruction Ravi Rao, IBM TJ Watson Research Center, NY High-performance computing techniques for neuro- image analysis Yoonsuck Choe, Texas A&M University Fast algorithms for reconstructing cortical neural circuits