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High prevalence of abnormal cervical cytology in young women with genital warts Chenchit Chayachinda, High prevalence of abnormal cervical cytology in young women with genital warts Chenchit Chayachinda, Manopchai Thammakhantho, Chanon Nuengton, Amphan Chalermchockcharoenkit, Isarin Thanabunyawat Methods Gynecolologic Infectious Disease and Female STD Unit, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Genital warts and cervical intra-epithelial habits such as smoking, multiple sex partners and Genital warts Syphilis Thailand, 10700 This retrospective cohort study included neoplasia (CIN) are both associated with condom usage refusal usually come along. (n= 53) (n= 2) human papillomavirus (HPV) infection. Although the etiologic HPV types are different, the occurrence of genital warts may be a marker of a relative deficiency in immune response that can be a factor for cervical intra-epithelial lesion. From literature review, only few studies have been conducted to explore this issue but all of them showed a significant Year Count n Design Pap Colposco association. ry smear pic Bx (LSIL+) 1992 1 N. Irelan d 10 Initial 0 Pap smear 10 years later (CIN+) 15(15%) - 12(12%) 99(20%) 2005 ASCUS+ 13. 5% => CIN 10. 8% Israel 2011 Croati 4 a 74 Crosssection al Genital warts (n= 293) Syphilis (n=104) P 26. 8 ± 8. 8 49. 7± 15. 5 <0. 0 1 20. 6 ± 3. 0 23. 5 ± 4. 0 <0. 0 1 Age at first intercourse (year) 20. 3 ± 4. 8 20. 8 ± 4. 0 0. 35 37(37%) 2003 Canad 49 Cohort 2 a 6 (10 year s) 3 600 women with either genital warts or syphilis who attended Siriraj Female STD Clinic from 2007 -2011. Exclusion criteria were pregnancy, HIV infection, known case of cervical cancer or genital warts, rape case and being a commercial sex worker. Eligible subjects were 104 women with latent syphilis and 293 women with genital warts. The diagnosis of cervical intraepithelial neoplasia was based on liquid-based Pap smear, colposcopy and/or biopsy. Loop electrical excisional procedure Results (LEEP) was performed when 149(30%) 22 Cohort 111(50% 78(35. 3%) 1 (7 years) ) Age (year) Body mass index (kg/m 2) Number of sex partner Pap smear (LSIL+) LSIL 44 0 ASC-H 3 1 HSIL 6 0 AGC 0 1 a Negative 1 1 Chronic inflammation 1 0 HPV infection 2 0 CIN I 4 0 CIN II-III 7 1 a 38 b 0 Colposcopic Bx No biopsy <0. 0 1 These factors increase oncogenic human papillomavirus (HPV) exposure. The malignant transformation of cervix takes 10 -15 years resultin the higher prevalence in the older women. LSIL; low grade squamous intra-epithelial lesion, ASC-H; atypical squamous cell cannot exclude HSIL, HSIL; high grade squamous epithelial lesion, AGC; atypical glandular cells, Bx; biopsy, CIN; Cervical intra-epithelial neoplasia a. Same 3: Abnormal cervical cytology Table patient b. Colposcopic finding appeared negative. Genital warts Syphilis (n= 7) (n= 1) The present study demonstrated that such transformation was strikingly faster among young women who had genital warts. Comparison to olde women with syphilis was aimed to illustrate how hu the interaction of different HPV-related diseases w This can be explained by the individual’s probable relative immunodeficiency toward HPV and the co-infection of the non-oncogenic and oncogen HPV infection 5. Conclusion The high prevalence of LSIL+ among young women with genital warts supports the relation among diseases causing by different HPV types. References 1. Handley J, Lawther H, Homer T, Maw R, Dinsmore W. Ten year follow-up study of women presenting to a Negative 1 0 <0. 0 genitourinary medicine clinic with anogenital warts. Int J Cancer 6(2. 7%) CIN I 1 0 Parity 0. 4 (0 -4) 2. 6 (0 -8) 1 STD AIDS. 1992; 3(1): 28 -32 Table 1: Literature review on prevalences lesions, LSIL; low grade squamous intraepithelial of abnormal cervical. CIN II-III 5 1 2. Li J, Rousseau MC, Franco EL, Ferenczy A. Is Abortion 0. 3 (0 -4) 0. 4 (0 -4) 0. 08 cytology in women with genital warts ASCUS; CIN; cervical intraepithelial neoplasia, colposcopy warranted in women with external anogenital CIN; Cervical intra-epithelial neoplasia Table 2: Characteristics of the participants Data was shown in mean ± S. D. or mean with warts? . Journal of lower genital tract disease. 2003; 7(1): atypical squamous cells of undetermined range with genital 22 -28 Objectives significance Table 4: Loop electrical escisional procedure (LEEP) results Women as appropriate. warts had 9 times higher 3. Sadan O et al. Occurrence of cervical intraepithelial To compare the prevalence of low grade squamous prevalence of LSIL+ than ones with latent syphilis neoplasia in generally healthy women with exophytic Discussion valvar condyloma acuminata. Infectious diseases in intra-epithelial lesions and more (LSIL+), as well as its (18. 1% vs 1. 9%, p < 0. 05). Age, body mass had Obstetrics and Gynecology. 2005; 13(3): 141 -3 associated factors, between women with genital warts (BMI) and number of sex partners revealed Sexually transmitted infection is one of the risk factors index 4. Milojkovic M, Milojkovic D, Russo M, Vakan BV. High and ones with syphilis. significant difference. squamoua intra-epithelail lesion and cancer of lower of cervical cancer development because other social genital tract in women with anogenital warts. Arch Gyenol Obster. 2011: 284: 453 -7 TEMPLATE DESIGN © 2008 www. Poster. Presentations. com 2. 1 (1 -10) 1. 5 (1 -2)