Hawaii Biotechnology Research: Interest Areas and Opportunities with the Department of Defense COL Karl Friedl, Ph. D Telemedicine & Advanced Technology Research Center US Army Medical Research & Materiel Command Frederick, MD COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide of 48
A hiatus exists between the inventor who knows what they could invent, if they only knew what was wanted, and the soldiers who know, or ought to know, what they want and would ask for it if they only knew how much science could do for them. - Winston S. Churchill (1929) COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 2 of 48
Agenda • Military medical research interests • Biomedical research in the Do. D • USAMRMC organizational structure • Competitive funding opportunities • Hawaii Federal Healthcare Network Program COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 3 of 48
Technology Shortfalls: Fill the Gaps Current Operational Concepts and Environment Future Operational Concepts and Environment Needed S&T Work S&T Shortfalls Needed S&T Work Ongoing S&T Work Existing Tech or Non-Technology Solutions Capability Needs Capability Challenges Desired Capabilities Existing Tech or Non-Technology Solutions Capability Today COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide of 48
The Linear Approach to R&D Army Medical Product Development Life Cycle Fed / Do. D Needs ICD CDD CPD Opportunities, Gaps, & Resources Funding Life Cycle MDD 6. 1 A 6. 2 B 6. 3 6. 4 Research, Development, Test, & Evaluation (RDT&E) $ Do. D Funding Categories 6. 1 – 6. 3: Basic research, applied research, and advanced technology development 6. 4 – 6. 5: Program management activities 6. 6: Program support including test and evaluation facilities 6. 7: Improvements to existing operational systems Joint Capability Integration & Development System Documents ICD: Integrated Capabilities Documents CDD: Capability Development Documents CPD: Capability Production Documents COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Program Management Initiation 6. 5 C 6. 7 Procurement $ Ops & Maint $ Vannevar Bush model Basic research is a pacemaker of technological innovation but must be segregated to avoid premature thoughts of practical use UNCLASSIFIED Slide 5 of 48
Do. D Problem-solving Focus: Use-inspired Medical Research Understanding underlying science creates rule base to help solve future problems Low Emphasis on Fundamental Understanding Revolutionary Pure basic research (Bohr) Low Emphasis on Applications High Emphasis on Basic Science Pure applied research (Edison) Evolutionary COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Use-inspired basic research (Pasteur) Slide 6 of 48
What are the Do. D Medical Research Priorities? (Where do they come from? ) • National strategic plans (e. g. , Quadrennial Review – in progress!) • Secretary of Defense & other authoritative sources in the Do. D and Services • Armed Services Biomedical Research Evaluation and Management • Near-term problems identified by field commanders & COCOMs COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 7 of 48
Secretary Gates' Press Briefing May 3, 2007 Apart from the war, this department and I have no higher priority than to ensure wounded servicemembers have the best care and facilities and ample assistance navigating the next step in their lives. That is what we intend to give them. COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 8 of 48
Current Priorities: Secretary Gates' Budget Briefing April 6, 2009 Recognize the critical and permanent nature of wounded, ill and injured, traumatic brain injury, and psychological health programs. This means institutionalizing and properly funding these efforts in the base budget and increasing overall spending by $300 million. The department will spend over $47 billion on healthcare in FY 10. COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 9 of 48
Enduring Challenges: Old Medical Threats, New Science LIMB LOSS SHELL SHOCK HEMORRHAGE COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 10 of 48
Core Medical R&T Responds to Threats to Soldier Health and Performance Endemic Disease Threats • Parasitic Diseases • Bacterial Diseases • Viral Diseases Chemical/Biological Warfare Threats • Bacterial Threats • Viral Threats • Toxin Threats • Nerve Agents • Vesicant Agents • Blood Agents Environmental Hazards • Heat and Cold • Altitude • Toxic Industrial Chemicals & Materials COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Operational Stressors • Sleep Deprivation • Traumatic Stress and Situational Stressors • Physical Work Load • Cognitive Burden & Operational. Injuries Combat Complexity • Hemorrhage • Head Trauma • Blast Injury Inadequate Medical C 4 ISR UNCLASSIFIED Systems Hazards • Laser • Blast • Biomechanical Insults and Stresses • Noise Slide 11 of 48
Pharmaceutical Advanced Development Pipeline at USAMMDA Pre-Clinical Phase 1 Phase 2 Phase 3 Licensed VACCINES (License Submitted) (Proof-of-Concept Completed) Adenovirus Type 4 & 7 HIV Prime-Boost (Proof-of-Concept) Dengue Tetravalent ANTIPARASITIC DRUGS/Dx Leish Drug, Pentostam. TM Antimalarial-IV Artesunate Topical Leishmania Drug Antimalarial-Tafenoquine (Proof-of-Concept) Leish Rapid Diagnostic COMBAT CASUALTY CARE Intranasal Ketamine RBCs Extended Life Cryopreserved Platelets Freeze-Dried Plasma COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 12 of 48
Joint Force Health Protection Capability Gap Medical R&D OVERARCHING NEEDS: Maintain a Healthy & Fit Force Protect Personnel in the Field Military Infectious Diseases Research Program Medical Biological Defense Research Program Vaccines and pre-treatments Small molecule therapeutics Next generation diagnostics Animal model development Broad-spectrum therapeutics Vaccines Prophylaxis/treatment drugs Diagnostics/prognostics Vector control HIV countermeasures (Congressional mandate) Medical Chemical Defense Research Program Combat Casualty Care Research Program Nerve agent pre-treatments Therapeutics for nerve agents Therapeutics for vesicant injury Diagnostic assays/technologies Meet Demands on First Responders Reduce the Number of Deaths on the Battlefield Limit Brain Damage Improve Medic, Provider, and Team Training Restore Full Function Improve En Route Care Reduce Morbidity and “Died of Wounds” Rate Clinical Trials Clinical and Regenerative Medicine Research Program Improve Prosthetic Function Enhance Self Regenerative Capacity Improve Limb/Organ Transplant Success Create Fully-Functioning Limbs/Organs Military Operational Research Program Prevent, Detect and Treat Mental Health Problems and m. TBI (Concussion) Prevent/Mitigate Blast, Blunt, Ballistic, and Impact Injury Reduce Attrition in Basic Combat Training Due to Injury and Mental Health Problems Prevent/Mitigate Injury from Environmental Exposures to Heat/Cold/Altitude and Toxic Chemicals and Materials Sustain Soldier Performance COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Diagnosis for Early Treatment Rapid Return to Duty Blast Injury Program Coordinating Office Develop Medical Standards for Individual and Combat Vehicle Crew Blast Protection Systems Elucidate the Mechanism of Blast-Induced Brain Injury Improve Diagnosis of m. TBI Effectively Communicate Blast-Related Research Across the Do. D Reset Advance Treatment Options UNCLASSIFIED Slide 13 of 48
Key Blast Injury Research Topics (FY 07 -10 Investments) Injury Prevention ($183 M) • Existence and mechanism of non-impact, blastinduced m. TBI? • Drugs to prevent and treat blast-related hearing loss • Analysis of combat injuries and PPE performance (JTAPIC) • Multi-effect blast injury models to improve protective equipment • Resilience enhancement and prevention of PTSD Acute Treatment ($437 M) • Diagnostics and neuroprotectant drugs for TBI • Hemorrhage control & blood products • Treatment of psychological trauma • Damage control orthopedics • Pain management Hair Cell Antioxidan t Defenses CFD Simulation Observed Blast Loading Conditions Test Pathology FEM Simulation Reset ($141 M) • Tissue engineering and prosthetics • Return-to-duty Standards • Recovery of function COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Before UNCLASSIFIED After Slide 14 of 48
Do. D Blast Injury Research Extends Back to World War II Nuclear & conventional explosions Los Alamos & Albuquerque Cave blasts Armored Med Res Lab COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 15 of 48
New Science and Technology Options: Modernization of Military Medical R&D Prevention (Mitigate Risk) Acute Treatment (Mitigate Injury) Reset (Mitigate Disability) ØSystems Biology Methods Personalized Medicine Diagnostics Regenerative Medicine “Laying the tracks for the train” ØAdvanced Training Technologies & Neuroplasticity Individual Resilience Provider Training Individual Retraining ØComputational Bioengineering, Biomaterials & Nanotechnologies Biomedical Standards Wound Care Advanced Prosthetics ØElectronic Health Record Outcomes Research Injury Surveillance Optimized Interventions COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Return-to-Duty Standards Slide 16 of 48
Chemical Biological Defense Program Threat Focus • Advanced Threats – pathogens engineered to increase resistance, transmissibility, and virulence • Traditional Threats – intracellular bacterial pathogens (e. g. , plague) – viral hemorrhagic fevers (e. g. , ebola) • Enhanced Threats – “bioprospecting” of virulent strains in nature – cultivating virulent strains in the laboratory • Emerging Threats – natural diseases (e. g. , pandemic flu, malaria) – multidrug and vaccine resistant pathogens COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 17 of 48
Chemical Biological Defense Program: Transformational Medical Technologies Initiative • Develop broad-spectrum countermeasures and novel technology platforms (one drug, many bugs) • Pursue countermeasures targeting common disease pathways or enhance the host’s immune system • Integrate best efforts within government, academia, Do. D, biotech industry, and small and large pharmaceutical corporations • Provide seamless “end-to-end” product development • Eliminate capability gaps by adding promising candidate technologies to the pipeline www. tmti-cbdefense. org; ww. fedbizops. gov COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 18 of 48
The Changing Operational Environment “Low level Persistent Conflict” General Casey, 14 Aug 07 COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 19 of 48
The Changing Operational Environment “Low level Persistent Conflict” General Casey, 14 Aug 07 Stability Operations & International Health COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 20 of 48
Medical Research and Related Programs in the Do. D Services ARO ONR AFOSR DCo. E for PH and TBI DCo. E for Vision USAMRMC NMRC ONR DARPA (e. g. , DSO) CBDP/DTRA (e. g. , TMTI) SOCOM (BISC) VA-Do. D sharing (e. g. , JIF) AFRL COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Other Agencies AFMOA UNCLASSIFIED NIH joint efforts Slide 21 of 48
Medical Research and Related Programs in the Do. D Services ARO ONR AFOSR DCo. E for PH and TBI DCo. E for Vision USAMRMC NMRC ONR DARPA (e. g. , DSO) CBDP/DTRA (e. g. , TMTI) SOCOM (BISC) VA-Do. D sharing (e. g. , JIF) AFRL COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Other Agencies AFMOA UNCLASSIFIED NIH joint efforts Slide 22 of 48
Armed Services Biomedical Research Evaluation & Management The ASBREM Committee shall: • Review medical RDT&E program plans and accomplishments for quality, relevance, and responsiveness to military operational needs, the needs of the Military Health System, and the goals of Force Health Protection • Review program plans and budgets in support of the various guidance documents relevant to National Security and to the missions and functions of the Department of Defense • Provide coordination, recommendations, and support to Do. D Executive Agencies and other Do. D officials as requested, directed, or otherwise appropriate COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 23 of 48
Medical Research and Related Programs in the Do. D ASBREM Joint Technical Coordinating Groups 1 2 3 4 5 6 7 8 Med Training Systems & Information Tech Military Infectious Diseases Chemical Defense Biological Defense Military Operational Medicine Combat Casualty Care Radiation Effects Clinical and Rehabilitative Medicine COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 24 of 48
Defense Health Program: GDF Enhancement MISSION DESCRIPTION AND BUDGET ITEM JUSTIFICATION: This Program Element (PE) funds Advanced Component Development of medical products that are regulated by the U. S. Food and Drug Administration (FDA) and the accelerated transition of FDA licensed and unregulated products and medical practice guidelines to the military operational user through clinical and field validation studies. Projects in this PE are designed to address areas of interest to the Secretary of Defense and to close medical capability gaps associated with the Joint Force Health Protection Concept of Operations (JFHP CONOPS) and are complementary to research conducted by the Army, Navy and Air Force in analogous PEs. Projects include Trials for Accelerated Transition of Modeling and Simulation Technology for Medical Training/Education/Treatment; Trials for Accelerated Transition of Medical Technology, Practice Guidelines and Standards; Medical Products – Advanced Component Development; and Medical Information Technology Development. $198 M COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 25 of 48
Congressional Special Interest (CSI) RDA Programs About 50% of USAMRMC Funding Each Year Is Congressionally Directed Function of Congressional Special Interest (CSI) Research: • Sponsor good science using Congressional appropriations that are not in the President’s budget Advanced Development 9% • Responsive to the intent of Congress, managed to Core R&T 33% maximize military relevance Process: Core • Proposals peer reviewed for scientific merit prior to Effort award 39% • Programs executed by extramural awardees and USAMRMC laboratories and acquisition offices Program Managers: • USAMRMC Research Area Directorates (33%) • U. S. Army Medical Materiel Development Activity (USAMMDA – 9%) • Congressionally Directed Medical Research Programs TATRC 29% CDMRP 32% • Telemedicine and Advanced Technology Research Center COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 26 of 48
Medical Advanced Development Supporting Commands USAMMDA USAMMA U. S. Army Medical Materiel Development Activity U. S. Army Medical Materiel Agency Defense Medical Logistics Center Pharmaceutical Systems Applied Medical Systems COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Integrated Clinical Systems UNCLASSIFIED Medical Devices Slide 27 of 48
Core Medical R&T Supporting Laboratories USAARL USAISR U. S. Army Aeromedical Research Laboratory U. S. Army Institute of Surgical Research USARIEM U. S. Army Research Institute of Environmental Medicine Combat Casualty Care 18. 3% Military Operational Medicine 17. 1% Medical Biological Defense 25. 5% Military Infectious Diseases 23. 6% Medical Chemical Defense 15. 5% USAMRIID U. S. Army Medical Research Institute of Infectious Diseases USAMRICD U. S. Army Medical Research Unit - Nairobi, Kenya Armed Forces Res Inst of Med Sci, Bangkok, Thailand US Army Medical Research Unit, Heidelberg, Germany US Army Dental and Trauma Research Detachment US Army Medical Research Detachment WRAIR Walter Reed Army Institute of Research COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED U. S. Army Medical Research Institute of Chemical Defense US Army Center for Env Health Med Slide 28 of 48
http: //cdmrp. army. mil/ FY 09 Funding Opportunities: COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 29 of 48
http: //cdmrp. army. mil/ COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 30 of 48
Medical Research and Related Funding Programs in the Do. D Services ARO DCo. E for PH and TBI DCo. E for Vision USAMRMC Other Agencies DARPA (e. g. , DSO) CBDP/DTRA (e. g. , TMTI) NMRC Small Business Innovative Research SOCOM (BISC) ONR Small Business Technology Transfer VA-Do. D sharing (e. g. , JIF) (SBIR/STTR) AFRL AFOSR http: //www. acq. osd. mil/osbp/sbir/ efforts NIH joint AFMOA COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 31 of 48
KEY TATRC Initiatives and Portfolios • Cell phone-based systems • Remote biomonitoring • Global Biosurveillance • Health information portal unified EHR • Research data cube/ medical outcomes • Pharmacovigilance • Virtual environments • Computational models & tools • Human/soldier phenome • Performance & injury prediction models e. HEALTH MEDICINE IN AUSTERE ENVIRONMEN TS HOSPITA L OF THE FUTURE DIGITAL WARRIOR INTEGRATI VE MEDICINE www. tatrc. org COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil • Robotic rescue & evacuation • Shelf stable diagnostics & vaccines • Blood products & blood safety UNCLASSIFIED • Natural orifice transluminal endoscopic surgery • Advanced medical imaging • Distance medical training & simulation • Operating room of the future • Prosthetics and human performance • Regenerative medicine & biomaterials • Optimal healing environments • Advanced pain management • Complementary and alternative medicine • Neuroplasticity/resilience • Genomics/personalized medicine Slide 32 of 48
TATRC Portfolios Joint Technical Coordinating Group 1. Medical Information & Training Technologies 4. Infectious Diseases Human Performance Optimization Psych Health Resilience & Retraining Dr. Shore Simulation & Training Technology MAJ Brininger Dr. Cardin Mr. Wiehagen Genomics / Proteomics International Health Medical Imaging Technologies Health Information Technologies Ms. Stanley Ms. Barrigan Dr. Pacifico LCDR Steffensen Infectious Disease Medical Logistics Blood Products & Safety Dr. Carney Mr. De. Pasquale Mr. Malloy COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Trauma Dr. Broderick 5. Military Operational Medicine 6. Combat Casualty Care 8. Clinical & Rehabilitative Medicine Bio-Monitoring Technologies Medical Robotics Advanced Prosthetics Dr. Lai Dr. Gilbert Mr. Turner Computational Biology Nano-Medicine & Biomaterials Regenerative Medicine Dr. Reifman Dr. Grundfest Dr. Lai Head & Spinal Cord Injury Dr. Curley UNCLASSIFIED Vision Mr. Read Acoustic Trauma Dr. Holtel Slide 33 of 48 Slide 33 of 12
Hawaii Federal Health Care Network (AKAMAI II) – FY 10 Competitive RFP AKAMAI II supports applied research, development and deployment of telehealth and healthcare technology, biotechnology, clinical informatics, VA/Do. D systems interoperability, to improve access and the quality of care to service members, their families, and impacted communities. With a focus on programs that align closely with military medical requirements, a competitive process will be used to provide funding in Hawaii to develop advanced medical technologies and biotechnology research critical to our nation's military medicine and the warfighter. Priority will be given to innovative collaborations between Hawaii-based industries and the Department of Defense. Outside partnerships that help to bring unique expertise to research in Hawaii to solve military medical problems will also be an important factor. http: //inouye. senate. gov/Congressional_Initiatives/ COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 34 of 48
Basic Steps to Innovation in the Hawaii Federal Health Care Network 1. Come up with a concept that would be immensely important to the Do. D, if successful 2. Secure the intellectual property 3. Publish the seminal supporting article in peer reviewed literature 4. Conduct the initial risk mitigation studies (e. g. , toxicity) that will encourage investors COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 35 of 48
Hawaii Biomedical Research Advantages and Dual Use Applications for Do. D • Stable population (~1. 2 M) • Unique healthcare system and Do. D-VA sharing of facilities (great starting point to optimize practices) • Distributed across islands (e. g. , model of remote health care access) • Chronic health care concerns, even though a state with the best longevity (e. g. , preventive medicine interventions and personalized health care/personal empowerment opportunities) • Modest size makes manageable testbed and model system and increases cooperation in the islands COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 36 of 48
AAMTI: Pediatric Telecardiology Referrals with Echocardiographic Validation AMEDD ADVANCED MEDICAL TECHNOLOGY INITIATIVE Pacific Rim Pediatric Heartsounds Trial: Store and Forward telcardiology with echocardiographic validation Pediatric Multi-site Phonocardiography: Automated interpretation of pediatric heartsounds Simultaneous Multi-site Phonocardiography: A simplified heartsound COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil Improved heartsound signal analysis using simultaneous multi-site phonocardiograms in children UNCLASSIFIED Telecardiology evaluation of newborns with heart murmurs using simultaneous, multi-site phonocardiography Slide 37 of 48
Janus – Do. D and VA Common Data View COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 38 of 48
Pacific Asynchronous Tele-Health (PATH) Teleconsultation Telehealth Services -VA Pacific Islands Health Care System (VAPICS) COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 39 of 48
ICU Multipoint Military Pacific Consultation Using Telehealth (IMMPACT) Telehealth Voice Therapy in Remote Regions in the Pacific Basin COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 40 of 48
Environmental Medical Surveillance (CBI “wet ware” / “canary”) Cell Matrix Chips for Air/Water Monitoring of Toxic Chemicals Principal Investigator: Kevin Chinn, Ph. D; Cellular Bioengineering, Inc. COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 41 of 48
Cell-based Treatments Treatment of Peripheral Vascular Disease by Adipose Derived Stromal Cell Injection Development of Technologies for Bioengineered Tissue Repair Principal Investigator: Paul Kosnik Ph. D; Tissue Genesis, INC. Principal Investigator: Mark Mugiishi, MD; Cellular Bioengineering, Inc. COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 42 of 48
Nanotechnology Capabilities RAIDER: Rapid Adverse Identifier for Drugs and Evaluation Resource Principal Investigator: Joanne S. M. Ebesu, Ph. D. ; Oceanit SEM image of nanoarray functionalized with antibodies COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 43 of 48
Development of the versa. HSDI system – Colon • Automated disease detection • Video reconstructed colon model • Local 3 D rendering 3 -D rendering software development to enable and develop Computer Aided Diagnosis and in situ pathology for colon cancer detection COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide of 48
Neurophysiologically-based Performance Monitoring and Enhancement Devices Intelligent PTSD Classification and Treatment-Augmentation Technology The device will utilize off the shelf technology and Archinoetics developed hardware to produce an integrated, unobtrusive Physiologic Warfighter monitoring/communication System Interface Research capability. COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide of 48
Broadband Respiratory Virus Surveillance COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide of 48
Sim. Center Hawaii Technology Enabled Learning and Intervention Systems Virtual Reality Applications for Health Care Education and Training COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 47 of 48
TATRC Science & Engineering Research Support Dr. Stan Saiki, Chief, TATRC Hui Dr. Chuck Peterson, Chief Scientist Ms. Jessica Kenyon, Chief, TATRC West Mr. Ron Marchessault, ORTA www. tatrc. org COL Karl Friedl/MCMR-TT (301 -619 -7967) (DSN 343) karl. friedl@us. army. mil UNCLASSIFIED Slide 48 of 48
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