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GPS-enabled inhaler to support real-time mapping of asthma exacerbations Team: Michael Alexander, Samantha Bergh, GPS-enabled inhaler to support real-time mapping of asthma exacerbations Team: Michael Alexander, Samantha Bergh, Mollie Lange and Peter Ma BME 301 March 2007

Client David Van Sickle, Ph. D. Robert Wood Johnson Health & Society Scholar Department Client David Van Sickle, Ph. D. Robert Wood Johnson Health & Society Scholar Department of Population Health Sciences Advisor Ken Gentry Department of Biomedical Engineering

University of Wisconsin - Madison Biomedical Engineering Design Courses INTELLECTUAL PROPERTY STATEMENT All information University of Wisconsin - Madison Biomedical Engineering Design Courses INTELLECTUAL PROPERTY STATEMENT All information provided by individuals or Design Project Groups during this or subsequent presentations is the property of the researchers presenting this information. In addition, any information provided herein may include results sponsored by and provided to a member company of the Biomedical Engineering Student Design Consortium (SDC). Anyone to whom this information is disclosed: 1) Agrees to use this information solely for purposes related to this review; 2) Agrees not to use this information for any other purpose unless given written approval in advance by the Project Group, the Client / SDC, and the Advisor. 3) Agrees to keep this information in confidence until the relevant parties listed in Part (2) above have evaluated and secured any applicable intellectual property rights in this information. 4) Continued attendance at this presentation constitutes compliance with this agreement.

Contents Content Humongous Insurance Problem Statement Background Motivation Design Constraints Proposed Designs Design Matrix Contents Content Humongous Insurance Problem Statement Background Motivation Design Constraints Proposed Designs Design Matrix Future Work

Problem Statement ¡ Time, date, location of inhaler use ¡ Development of a web-based Problem Statement ¡ Time, date, location of inhaler use ¡ Development of a web-based mapping and analytic system (future semesters).

Background Asthma ¡ A chronic respiratory disease in which the airways are blocked or Background Asthma ¡ A chronic respiratory disease in which the airways are blocked or narrowed due to allergy or inflammation. ¡ ~ 20 million Americans affected by this disease.

Background GPS ¡ First developed for the military. ¡ Widely used in communication, recreation Background GPS ¡ First developed for the military. ¡ Widely used in communication, recreation and safety. ¡ Uses signal transmission time to triangulate its position

Motivation ¡ Tracking of allergy and asthma symptoms ¡ Outbreak control ¡ General health Motivation ¡ Tracking of allergy and asthma symptoms ¡ Outbreak control ¡ General health observations with respect to populations in certain areas ¡ Surveillance limited to the delayed analysis of hospitalizations for severe episodes ¡ Currently no product on the market

Design Constraints ¡ Must meet FDA standards for use ¡ Secure attachment for peripherals Design Constraints ¡ Must meet FDA standards for use ¡ Secure attachment for peripherals ¡ Subject to normal wear and tear ¡ Can be battery powered ¡ Wireless ¡ Accurate

Design 1: Pressure Detection with GPS Separate ¡ Pressure sensor mounted on inhaler ¡ Design 1: Pressure Detection with GPS Separate ¡ Pressure sensor mounted on inhaler ¡ Microcontroller contacts cell phone, which retrieves GPS coordinates ¡ Cell phone formats data and sends to central computer

Pros & Cons Ö Portable Ö No major modification to inhaler Ö No need Pros & Cons Ö Portable Ö No major modification to inhaler Ö No need to buy separate GPS × Difficult to set pressure threshold perfectly × Relies on cell phone, which is easily forgotten, to collect data

Design 2: Contact Detection with GPS Separate ¡ Circuit completes when inhaler depresses ¡ Design 2: Contact Detection with GPS Separate ¡ Circuit completes when inhaler depresses ¡ Microcontroller contacts cell phone to get coordinates ¡ Cell phone formats data and sends to central computer

Pros & Cons Ö Reduces false positives Ö Still very portable Ö No need Pros & Cons Ö Reduces false positives Ö Still very portable Ö No need to buy separate GPS × Major modification to inhaler × Again relies on cell phone to collect data

Design 3: Contact Detection with GPS attached ¡ Circuit completes when inhaler depresses ¡ Design 3: Contact Detection with GPS attached ¡ Circuit completes when inhaler depresses ¡ Onboard GPS retrieves date, time, location and stores in CPU memory ¡ Microcontroller attempts to connect to cell phone and sends the information via Bluetooth ¡ Cell phone formats coordinates and transmits

Pros & Cons Ö Few false positives Ö GPS directly attached Ö Temporarily stores Pros & Cons Ö Few false positives Ö GPS directly attached Ö Temporarily stores data just in case × Larger to accommodate GPS and Bluetooth × Increased cost, decreased battery life

Design Matrix Criterion (Weight) Patient Safety (3) Accuracy (3) Low Cost (3) Data Backup Design Matrix Criterion (Weight) Patient Safety (3) Accuracy (3) Low Cost (3) Data Backup (2) Feasibility (2) Ease of use (2) Connectivity (2) Portability (1) Battery Life (1) Aesthetics (1) TOTAL Design 1 5 3 3 Design 2 4 5 4 Design 3 4 5 2 3 3 5 5 5 72 3 3 5 3 5 76 5 5 5 4 3 3 4 81

Future Work Creation of an inhaler Sending of data Mapping Establish research protocol Patenting Future Work Creation of an inhaler Sending of data Mapping Establish research protocol Patenting Applying for funding

References Asthma and Allergy Foundation of America http: //www. aafa. org American Academy of References Asthma and Allergy Foundation of America http: //www. aafa. org American Academy of Allergy Asthma and Immunology http: //www. aaaai. org How Stuff Works: GPS http: //www. howstuffworks. com/gps. htm MDILog™, Doser. CT™, and Smart. Mist™ Product Specifications