Скачать презентацию Geant 4 Simulation Study for Proton Therapy Se Скачать презентацию Geant 4 Simulation Study for Proton Therapy Se

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Geant 4 Simulation Study for Proton Therapy Se Byeong Lee Medical Physicist, Ph. D. Geant 4 Simulation Study for Proton Therapy Se Byeong Lee Medical Physicist, Ph. D. The 3 rd FKPPL workshop , March 8 -9, 2011, Seoul, Korea Proton Therapy Center

Overview of NCC History 1989. 12. Plan to establish NCC formulated by Ministry of Overview of NCC History 1989. 12. Plan to establish NCC formulated by Ministry of Health and Welfare 1997. 7. Construction of NCC Hospital building completed 2000. 10. NCC started clinical care services 2005. 2. Proton Therapy Facility Installation 2005. 10. First Beam Production 2007. 3. 2010. 12 First Proton treatment start 648 patients treated in Proton Therapy Facility

Facilities in Research Institution Facilities in Research Institution

Proton beam facility in NCC Proteus 235 Specification Weight : 220 ton Height : Proton beam facility in NCC Proteus 235 Specification Weight : 220 ton Height : 210 cm Diameter : 434 cm Energy : 230 Me. V Max. extracted beam current : 300 n. A RF frequency : 106 MHz

Beam delivery Uncertainty Target Ex. ) 5 mm beam off on Target (1 portal) Beam delivery Uncertainty Target Ex. ) 5 mm beam off on Target (1 portal) - Proton : 100% 0% dose - Photon : 100% > 95% dose

Uncertainties on Proton Treatment Planning MGH study Uncertainties on Proton Treatment Planning MGH study

Motivation of MC Simulation Study for Proton Therapy • Proton Treatment Planning : Accurate Motivation of MC Simulation Study for Proton Therapy • Proton Treatment Planning : Accurate dose calculation ? • Radiation Shielding : Patient & worker safety ? • Patient simulation (Respiratory gating) : 4 D Dose distribution ? • Beam Nozzle simulation : Design study, QA ? Monte Carlo Simulation

MC simulation of Proton Beam System 1. Modeling Ø Modeling Nozzle Ø Modeling Treatment MC simulation of Proton Beam System 1. Modeling Ø Modeling Nozzle Ø Modeling Treatment scheme 2. User interface for M. C set-up Ø Convalgo (“Conversion Algorithm” by IBA) interface 3. Validation Ø Ø Ø 4. Geant 4 physics test on CSDA range and non-elastic interaction probability Bragg peaks comparison Conversion function (Range 2 MCEnergy) Applications Ø SOBP reproduction for Proton therapy

1. Modeling - nozzle Framework libraries User applications 1. Modeling - nozzle Framework libraries User applications

2. User Interface input Rp (Range in Patient), SOBP CONVALGO output Measurement Scatterers setting 2. User Interface input Rp (Range in Patient), SOBP CONVALGO output Measurement Scatterers setting Variable collimator opening R. M wheel with BCM database Snout positioning Cyclotron energy, current. . . /GTR 2/SNT/type 250 /GTR 2/SNT/aperture/rectangle open /GTR 2/SNT/aperture/rectangle Lx Ly Ox Oy #Geant 4 kernel initialize /run/initialize /GTR 2/FS/lollipops 9 5 /GTR 2/SS/select 3 /GTR 2/RM/track 5 /GTR 2/RM/angle 80. 26 /GTR 2/VC/set. Vx. Vy cm 14. 2 15. 2 Nozzle configuration Treatment Control System (TCS) - not clinical mode Monte Carlo /BTS/particle proton /BTS/energy E Me. V 181. 8 1. 2 /BTS/geometry mm 3 5 /BTS/emittance G mm 1. 5 Init. Beam configuration /TCS/passive/BCM TR 2_B 6_1 144 1000 /TCS/Start. Irradiation BCM pattern BTS : Beam. Transport. System, TCS : Treatment. Constrol. System

3. Validation test of Nozzle Modeling Geant 4 version: 8. 2. p 01 MC 3. Validation test of Nozzle Modeling Geant 4 version: 8. 2. p 01 MC Simulation - EM model : G 4 h. Ionization with ICRU 49 parameterized table - Hadronic : LHEP_PRECO_HP ( precompound model ) NCC Proton Beam Delivery MC Simulation 11

4. Application : Proton Treatment Beam MC Sim. Ø various beam modeling Ø DICOM 4. Application : Proton Treatment Beam MC Sim. Ø various beam modeling Ø DICOM data handling Ø Dose calculation using Geant 4 MC simulation 12

4. Application : Medical Imaging tool (g. Mocren – KEK ) Patient CT Image 4. Application : Medical Imaging tool (g. Mocren – KEK ) Patient CT Image Reconstruction Proton beam irradiation simulation on a Patient body with CT image

FKPPL VO Grid Testbed FKPPL VO VOMS CE CE LFC SE IN 2 P FKPPL VO Grid Testbed FKPPL VO VOMS CE CE LFC SE IN 2 P 3 Service UI SE KISTI Host WMS UI Site kenobi. kisti. re. kr KISTI geant 4. ncc. re. kr VOMS NCC palpatine. kisti. re. kr KISTI WMS/LB snow. kisti. re. kr, snow 02, snow 03(LB) SE WIKI KISTI CC-IN 2 P 3 hansolo. kisti. re. kr (3 TB) CE ccsrm 02. in 2 p 3. fr (0. 5 TB) KISTI cclcgceli 03. in 2 p 3. fr (6905 CPU cores) CC-IN 2 P 3 darthvader. kisti. re. kr (128 CPU cores) KISTI

JOB Performance test on GRID JOB Performance test on GRID

Motivation : Relative Biological Effectiveness PMB 2004 J. J. Wilkens (ke. V/um) 16 [Figure Motivation : Relative Biological Effectiveness PMB 2004 J. J. Wilkens (ke. V/um) 16 [Figure courtesy of J. Gueulette, redrawn from the data of Menzel et al. , 1990, Loncol et al. , 1994, and Gueulette et al, 2004].

Proton RBE Measurement in NCC, Korea Plating HSG Cover Slide Assembling Cell holder Locating Proton RBE Measurement in NCC, Korea Plating HSG Cover Slide Assembling Cell holder Locating Cell holder in 50 fields Proton Beam Stacking Chamber Removing Cell holder Trypsin 2 -3 Weeks Digestion Replating in Culture Dish Counting Colony

Cell Survival in Depth Cell Survival in Depth

Measurement of DNA Breaks (Preliminary Exp. ) DNA Break (arb. value) 5 ul of Measurement of DNA Breaks (Preliminary Exp. ) DNA Break (arb. value) 5 ul of Plasmid DNA sample 0, 25, 50, 100, 200 Gy of Proton Beam (5 g/cm 2 at 210 Me. V) Gy Proton beam Dose DNA Break measurement with Electrophoresis

The collaboration Meeting On March 10, 2011 in NCC The collaboration Meeting On March 10, 2011 in NCC

Summary • Geant 4 simulation is useful and essential for Proton therapy study in Summary • Geant 4 simulation is useful and essential for Proton therapy study in NCC. • Geant 4 -DNA study for the calculation of proton RBE. • NCC Geant 4 Study with FKPPL & FJPPL VO. - Geant 4 -DNA (Sébastien Incert, IN 2 P 3 - CENBG) - GRID (Soonwook Hwang, KISTI) - Geant 4 -Particle. Therapy (Takashi Sasaki, KEK) • Extension of the collaboration with Gate & Radiobiology study(? ).

Thank you! Proton Therapy Center National Center for Cancer Prevention and Early Detection Research Thank you! Proton Therapy Center National Center for Cancer Prevention and Early Detection Research Institute Hospital