GALA 95 centres 24 countries 3526 patients Funding

GALA 95 centres 24 countries 3526 patients Funding: Health Foundation, ESVS

Countries & Centres Austria Australia Belarus China Croatia Czech Republic Estonia Georgia Germany Greece Hungary Israel Funding: Health Foundation, ESVS Italy Latvia Netherlands Poland Portugal Saudi Arabia Slovakia Spain Sweden Turkey UK Ukraine

Background Is it time for a randomized trial of local versus general anaesthesia for carotid endarterectomy? M. J. Gough, T. A. J. Calvey, A. J. Mc. Cleary, S. Whitely, A. Bodenham Leeds, UK Non-randomized, patients had a free choice of the type of anaesthetic. LA N=89 0 (0) 1 (1) 30 -day stroke rate Perioperative MI Death *P=0· 057 versus LA P=0· 046 versus LA for combined stroke/MI GA N=101* 4 (4) 3 (3) 2 (2) These results reinforce the need for a prospective, randomized trial. Funding: Health Foundation, ESVS

Introduction Eur J Vasc Endovasc Surg 13, 491 -499 (1997) Local Versus General Anaesthesia in Carotid Endarterectomy: a Systematic Review of the Evidence C. Tangkanakul, C. E. Counsell and C. P. Warlow Neurosciences Trials Unit, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, U. K. Eur J Vasc Endovasc Surg 12, 173 -181 (1996) The Differing Effects of Regional and General Anaesthesia on Cerebral Metabolism During Carotid Endarterectomy* A. J. Mc. Cleary, N. M. Dearden, D. H. Dickson, A. Watson M. J. Gough Departments of Vascular Surgery and Anaesthetics, The General Infirmary, Leeds, U. K. Funding: Health Foundation, ESVS

What Happened Next? CPW, MJG Steering Committee Protocol MREC Trial Co-ordinator Funding Pilot: 20 UK Centres Funding: Health Foundation, ESVS

GALA - continued • Pilot study completed • MREC approval for main trial • Funding: Health Foundation ESVS • Centre recruitment: Journal adverts Vascular Society Charing Cross European Meetings Funding: Health Foundation, ESVS • Trial Office: Bridget Colam Anne Fraser Steff Lewis Mary Paterson Vera Soosay Adam Young • Trial Steering Committee • Data Monitoring Committee