Functional MRI Research Gary H Glover Ph D

Functional MRI Research Gary H. Glover, Ph. D. Director, Radiological Sciences Laboratory Center for Advanced MR Technology* rsl. stanford. edu/research/ camrt. html Stanford University School of Medicine Department of Radiology *

f. MRI research in my lab Methodology of f. MRI acquisition, analysis, exp. design Neuro, breast

Spiral vs. EPI SNR EPI Spiral

Activation 1. 5 T 3. 0 T 0. 25 ≤ cc ≤ 0. 70

Brain Noise at 3 T Thermal noise 0 Phys. noise B Phys. noise NB Single-shot spiral: 64 x 64, TR 3000, TE 30 Krueger (MRM 2001)

Resting State 0. 35 ≤ r ≤ 0. 7, p<. 0. 0005 p/q 18944. 12110704

Default-Mode Network in AD healthy aging (A) AD (B) Greicius et al. , PNAS, 2004

Susceptibility Effects Mt TE SPIRAL OUT RF Gx SPIRAL IN SPIRAL OUT RF Gx C. Law, 2002

Novel vs. Repeated Pictures Out In-Out A. Preston, 7/02

Verbal Working Memory Task sprl-out sprl in-out 3 T M. Thomason

Sparse Temporal Sampling event related stim scan . . stim clustered scan sparse stim temporal (STS) scan Nadine Gaab

Pitch Memory 1 scan, 1 sec frames -5 s to 5 s p = 0. 0003 Nadine Gaab

Activation Time series

rtf. MRI System GE Signa 3 T Spiral Recon 1 vol. /TR 16 slc/s HR, resp. GSR, EMG Visual/audio stimuli Response devices TCP/IP Postprocessing response physio monitor stimuli gen

rtf. MRI Interface

rtf. MRI TRAINING SINGLE SUBJECT RESULTS B) Post-Training A) Pre-Training 1 -1 -2 R. 6. 4. 2 0 Average % signal Δ 2 L 2 1 -1 L. 6. 4 Average . 2 0 -2 EMG, m. V % signal R 1 0 -1 de. Charms et al, NI (2004)

f. MRI Results – Noxious Thermal Stimulation Anterior Cingulate C 5 -C 6 Somatosensory Cortex Mid-C 5 C 4 -C 5 Mackey, et al, (2004)

Effect of training (INCREASE – DECREASE) last run VS. (INCREASE – DECREASE) first training run L

Pain vs. activation in rostral anterior cingulate r. ACC activation (BOLD) 0. 6 * † 0. 5 0. 4 0. 3 0. 2 0. 1 0 Pain intensity rating (% difference) 50 Training run 1 Training run 2 Training run 3 * 40 Final test run 4 † 30 20 10 0 -10 Training run 1 Training run 2 Training run 3 Final test run 4

7 T Dreaming

7 T 230 m x 1000 m Courtesy Tie-Qian Li, NIH, 2005

7 T 500 m, 7 T Josef Pfeuffer, et al CMRR, UMN 900 m, 7 T Josef Pfeuffer, et al CMRR, UMN

f. MRI research in my lab Methodology of f. MRI acquisition, analysis, exp. design • some projects not shown: - BH challenge - fetal f. MRI - TMS/f. MRI - high res. f. MRI - EEG/f. MRI - localized shimming - 3 D f. MRI - Breast BOLD contrast • collaborations with many on campus • opportunities for rotation projects

My kids 7/2005

f. MRI studies at Lucas • ~25 PI’s in Psychology, Psychiatry, Neuroradiology, Neurosurgery, Neurobiology, Neurosciences • Currently ~110 students/postdocs, others • 220 members of fmri-group@lists. stanford. edu