Fish Genomics in Canada Christian Burks CBurks@Ontario. Genomics. ca www. Ontario. Genomics. ca
Fish Genomics in Canada • Ontario Genomics Institute • Fish Genomics Fish Barcode Workshop, 7 June ‘ 05, 2
From Central Dogma to Discovery Platforms genes proteins holistic, high-throughput & systematic approaches to building resources genomics proteomics Fish Barcode Workshop, 7 June ‘ 05, 3
Ontario Genomics Institute (OGI) Building a globally-competitive life sciences industry in Ontario • Fund top tier science & technology • Fund best organized projects • Facilitate & precipitate commercialization • Focus on societal outcomes • 50% co-funding requirement (international collaborations count) Fish Barcode Workshop, 7 June ‘ 05, 4
OGI R&D Project Portfolio • $320 M portfolio of 24 projects to date led by Ontario scientists • $3 M - $30 M per program ($10 M average) • human health, tech development, agriculture, forestry & environment • examine associated impact: ethics, environment, economic, legal & social • 2 “platform” projects: proteomics (PTCF) and genomics (GRC) Fish Barcode Workshop, 7 June ‘ 05, 5
International Programs Structural Genomics Consortium • Led by Aled Edwards @ University of Toronto • Detailed three-dimensional structure of 350 proteins (starting point for drug discovery) • $115 M • ICI: work being done in and funded by Canada, United Kingdom & Sweden Segmented DNA Duplications • • Ontario work led by Steve Scherer @ Hospital for Sick Children Duplicated DNA in neurodevelopmental-diseases and evolution $6 M work being done in and funded by Canada & Spain (Genoma España) International Regulome Consortium (in planning & development) • Led by Michael Rudnicki @ Ottawa Health Research Institute • map the mechanisms and networks that control the genes that comprise the genome • $$$ to be determined …. ultimately, $50 M - $100 M; program development funds from MEDT • potential ICI: Canada, Australia, France, Germany, Italy, Netherlands, Singapore, UK & USA Fish Barcode Workshop, 7 June ‘ 05, 6
Fish Genomics in Canada • Ontario Genomics Institute • Fish Genomics Fish Barcode Workshop, 7 June ‘ 05, 7
Atlantic Salmon Genomics Leads: Willie Davidson (Simon Fraser U. ) & Ben Koop (U. Victoria) Collaboration: Bjorn Hoyheim (Norwegian School of Veterinary Science) Sharing BAC libraries, ESTs, QTL markers, etc. Funding: $6 M (Genome Canada & others) & $6 M (Norway) Focus: Integrate genetic and physical maps Identify genes ( > 16, 000) linked to disease, stress, growth, and development use variation for identifying conservation units Characterize gene regions relevant to aquaculture immune system genes stress and disease sex determination Fish Barcode Workshop, 7 June ‘ 05, 8
Aquaculture Disease Management Lead: Laura Brown (NRC Institute for Marine Biosciences) Consortium: NRC Institute for Marine Biosciences, Halifax NRC Institute for Biological Sciences, Ottawa Dalhousie University, Department of Microbiology Fisheries and Oceans Canada Funding: $9 M (NRC’s Genomics and Health Initiative & others) Focus: genomics, proteomics & metabolomics to produce vaccines & vaccine delivery systems for Aeromonas salmonicida to understand the effects of husbandry stressors Fish on vaccine efficacy Barcode Workshop, 7 June ‘ 05, 9
Flatfish Genomics Leads: Susan Douglas (NRC IMB, Canada) & Joan Cerda Luque (IRTA, Spain) Consortium: Genome Canada (NRC IMB, Dep’t of Fisheries and Oceans, Scotian Halibut Ltd. ) government Genoma España (Nine academic & organizations, Oryzon Genomics) Funding: $5 M ($2 M from Genome Canada) Focus: Large-scale genomics and proteomics approaches to enhance the commercial culture of Atlantic Halibut and Senegal Sole. gene sequencing expression arrays genetic linkage maps Fish Barcode Workshop, 7 June ‘ 05, 10
Zebrafish Functional Genomics Lead: Marc Ekker (CAREG, U. Ottawa) Funding: CIHR, NSERC Focus: environment - impact of environmental stressors on genome expressivity identification of novel biomarkers human health - screens for novel mutations model Parkinson’s disease, heart arrhythmia & sexual differentiation reporter transgenic zebrafish for functional assays Fish Barcode Workshop, 7 June ‘ 05, 11
Ontario Genomics Institute Christian Burks CBurks@Ontario. Genomics. ca www. Ontario. Genomics. ca
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