European Cooperation in the field of Scientific and

European Cooperation in the field of Scientific and Technical Research www. cost. esf. org BMBS Action: Cancer and Control of Genomic Integrity Years: 2008 -2012 (CANGENIN) - BM 0703 Participating countries (22): Bulgaria, Croatia, Denmark, Estonia, Finland, FYR of Macedonia, Germany, Greece, Hungary, Israel, Italy, Lithuania, Netherlands, Norway, Poland, Serbia, Spain, Sweden, Switzerland, Turkey, United Kingdom, + Australia Chair of the Action: Dr. Carina Holmberg-Still Rapporteur: Dr. Mario Vallejo Science Officer: Dr. Magdalena Radwanska Action Website: http: //research. med. helsinki. fi/cost/default. htm Scientific background Cancer is a clinically debilitating disease with an increasing incidence especially in the aging population. Advanced knowledge of factors contributing to genome integrity and tumorigenesis will provide a more integrative view of tumor pathogenesis, thereby promoting development of new innovative strategies for cancer therapies. Sari Jaamaa, Univ. of Helsinki Objectives defined in the Mo. U ØMain objective: To advance knowledge on dysregulation of cellular protective responses against cancer and of epigenetic events involved. ØSecondary objectives: . Working Groups WG 1: Cellular DNA damage signalling pathways Claus Storgaard-Sørensen, Univ. of Copenhagen, Denmark WG 2: Chromatin modifications and transcriptional control Bruno Amati, European Institute of Oncology, Italy WG 3: Cancer epigenetics Rolf Ohlsson, Karolinska Institute, Sweden WG 4: Cancer model systems and translational research Jos Jonkers, Netherlands Cancer Institute, • Establish a network with top-level high impact research groups in genomic integrity, transcription control and cancer epigenetics; • Promote scientific interactions and excellence in Europe; • Promote rapid dissemination of information; • Bring together experts in cancer biology, animal models, and translational cancer research; • Support young investigators by providing interactions, technological advancements and intellectual feed-back; • Provide scientific and methodological research training for students. Scientific deliverables obtained due to networking Ø 18 joint publications (2010 – March 2011) exemplified by: • Beck, H. Nähse, V. Larsen, MS. Groth, P. Clancy, T. Lees, M. Jørgensen, M. Helleday, T. Syljuåsen, RG. Sørensen, CS. (2010). Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol. 188: 629 -38. • Bouwman, P. Aly, A. Escandell, JM. Pieterse, M. Bartkova, J. van der Gulden, H. Hiddingh, S. Thanasoula, M. Kulkarni, A. Yang, Q. Haffty, BG. Tommiska, J. Blomqvist, C. Drapkin, R. Adams, DJ. Nevanlinna, H. Bartek, J. Tarsounas, M. Ganesan, S. Jonkers, J. (2010). 53 BP 1 loss rescues BRCA 1 deficiency and is associated with triplenegative and BRCA-mutated breast cancers. Nat Struct Mol Biol. 17: 688 -95. • Campaner, S. Doni, M. Hydbring, P. Verrecchia, A. Bianchi, L. Sardella, D. Schleker, T. Perna, D. Tronnersjö, S. Murga, M. Fernandez-Capetillo, O. Barbacid, M. Larsson, LG. Amati, B. (2010). Cdk 2 suppresses cellular senescence induced by the myc oncogene. Nat Cell Biol. 12: 54 -59. • Mac. Kay, C. Déclais, A. Lundin, C. Agostinho, A. Deans, A. Mac. Artney, T. Hofmann, K. Gartner, A. West, S. Helleday, T. Lilley, D. Rouse, J. (2010). Identification of KIAA 1018/FAN 1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD 2. Cell. 142: 65 -76. Capacity building due to networking Ø 3 rd Annual Conference : “ 3 rd Genomic Instability Workshop” , 2023. 11. 2010, Milan, Italy. Organized together with a Nord. Forsk network and the GENICA FP 7 Health Programme Ø 10 STSMs (2010 -March 2011) ØTraining School : “High-throughput screens in genome integrity and cancer", 24 -27. 5. 2010, Oxford, UK Ø National and international spin-off network proposals/projects COST Visibility: websites, program & abstract books of meetings/TSs COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract