EULAR Gene and cell therapy Study Group Christian

EULAR Gene and cell therapy Study Group Christian Jorgensen INSERM 1183, Institute for Regenerative Medicine and Biotherapy, Montpelier , France Gene and cell therapy study group objectives § Lead : C Jorgensen, INSERM, Univ. Montpellier § Goal: the study group dedicated to gene and cell therapy organize scientific meetings, training program and participate to H 2020 programs. § The aim of the SGGCT is to build an international network of excellence in cell therapy & to develop novel immune therapy. § Active group of 25 teams, open for scientists or clinicians with special focus to translational clinical research. § Interactions with international societies including IRCS, ISCT, IFATS § Scientific interactions : meeting and collaborative work § cell based therapy : DC mediated therapy in RA, adult stem cell research, i. PS, CARTcell § Proof of concept : expertise in experimental arthritis an OA and arthritis models § nucleotide targets , micro. RNA identified in different cells (MSC, synoviocytes, Tcells, Tregs, monocytes). next step is delivery of small RNA. § Immunomonitoring SOP adapted to cell mediated therapy § Training: The Study group meeting are held during the workshops prior to the openings lecture at the EWRR 2017 in Athen with approx 25 scientists. Translationnal research § Translationnal research: Clinical programs are ongoing in Europe stimulated by EU partners with strategy using cytokine vaccination, T regulatory cell therapy and dendritic cells (Au. To. De. CRA), stem cell therapy supported by H 2020 : ADIPOA, RESPINE, EUROCELL § Perspectives: The gene and cell therapy study group aims to have two interactive meetings a year, one connected to the EWRR, the second one at the Eular meeting. • Info on EULAR website : https: //www. eular. org/investigative_rheumatology_study_groups. cfm EUROSTEM in EUROPE REGULATORY SOP Guidelines BIOBANKING EATRIS Bone. Bank, BBMRI Lubeck Univ/Odense Univ EWRR study group meeting CELL PRODUCTION Athens 2017 March 3, 13 h 00 -14 h 00, meeting room Chair : C Jorgensen Montpellier §Panos Viginis Novel role of plasmacytoid dendritic cells in RA pathogenesis §F Vandeloo : exosomes in experimental arthritis : a new biologic? §Natacha Bessis In Vivo Expansion of Activated Foxp 3+Regulatory T Cells in Experimental arthritis. §J Isaac : update on Autologous Tolerogenic Dendritic Cells for Rheumatoid and Inflammatory Arthristis (Au. To. De. CRA) – a phase 1 study §C Jorgensen : success on H 2020 project focusing on stem cell therapy in rheumaotlogy in 2016 §Round table. How to set pu successful EU consortium ECELL, DRK, EFS IRMB CLINICAL ECRIN STEM CELL BIOLOGY, SCAFFOLDS BASEL MC, IRMB