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ESFRI European Strategy Forum on Research Infrastructures ESFRI Roadmap of Research Infrastructures and the ESFRI European Strategy Forum on Research Infrastructures ESFRI Roadmap of Research Infrastructures and the Israeli Perspective David Horn, Tel Aviv University http: //horn. tau. ac. il July, 2009

ESFRI European Strategy Forum on Research Infrastructures General information • ESFRI, the European Strategy ESFRI European Strategy Forum on Research Infrastructures General information • ESFRI, the European Strategy Forum on Research Infrastructures, is a strategic instrument to develop the scientific integration of Europe and to strengthen its international outreach. • Founded in 2002. Members nominated by Member and Associate countries. • The mission of ESFRI is to support a coherent and strategy-led approach to policy-making on research infrastructures in Europe, and to facilitate multilateral initiatives leading to the better use and development of research infrastructures, at EU and international level. • Publication of first roadmap in 2006, and second roadmap in 2008. • Roadmaps are used by DG research as basis of appropriate calls for RI projects. 2

ESFRI European Strategy Forum on Research Infrastructures Roadmap structure • • Social Sciences and ESFRI European Strategy Forum on Research Infrastructures Roadmap structure • • Social Sciences and Humanities Environmental Sciences Energy Biological and Medical Sciences Materials and Analytical Facilities Physical Sciences and Engineering e-Infrastructures 3

ESFRI European Strategy Forum on Research Infrastructures Social Sciences and Humanities • European Social ESFRI European Strategy Forum on Research Infrastructures Social Sciences and Humanities • European Social Survey Upgrade of the European Social Survey, set up in 2001 to monitor longterm changes in social values Costs: construction 54 M, operation 9 M. (Noah Levin-Epstein, TAU) • SHARE Data infrastructure for empiric economic and social science analysis of ongoing changes due to population ageing Costs: 11. 6 M, 0. 3 M. (Howie Litwin, HU) 4

ESFRI European Strategy Forum on Research Infrastructures Biological and Medical Sciences • BBMRI Bio-banking ESFRI European Strategy Forum on Research Infrastructures Biological and Medical Sciences • BBMRI Bio-banking and biomolecular resources research infrastructure Costs: 170 M, 15 M. (INTB, Ciechanover et al ? ) • INSTRUCT Integrated Structural Biology Infrastructure Costs: 300 M, 25 M. (Joel Sussman, WIS) • ELIXIR Upgrade of the European Life-science infrastructure for biological information Costs: 470 M, 100 M. (Michal Linial, HUJ, Mo. S) 5

ESFRI European Strategy Forum on Research Infrastructures BBMRI: Biobanking and Biomolecular Resources Research Infrastructure ESFRI European Strategy Forum on Research Infrastructures BBMRI: Biobanking and Biomolecular Resources Research Infrastructure EC: 5 M€ 27 months 50 participants BBMRI will comprise • all major population-based and disease-oriented biobank formats • Biomolecular resources, such as collections of antibodies and other affinity binders and a variety of molecular tools to decipher protein interactions and function • bio-computing and sample storage infrastructure. BBMRI will provide: • Biobanks of different formats (based on collections of DNA, tissue, cells, blood and other body fluids, together with pertinent medical, environmental, life-style and follow -up data) • Population cohorts, including prospective and twin cohorts • Clinical case/control cohorts including disease-focused cohorts • Cohorts from isolated populations • Biomolecular resources (comprising antibody and affinity binder collections, ORF clone collections, si. RNA libraries, proteins, cellular resources etc. ) • Enabling technologies and high-throughput analysis platforms and integration of sites specialized in development of molecular tools to decipher gene, protein and metabolite functions and their interactions • Harmonized standards for sample collection, storage, preanalytics and analysis • Harmonized data collection, logistics and database- and biocomputing infrastructure • Ethical, legal and societal guidance and platform. 6

ESFRI European Strategy Forum on Research Infrastructures INSTRUCT: Integrated Structural Biology EC: 4. 5 ESFRI European Strategy Forum on Research Infrastructures INSTRUCT: Integrated Structural Biology EC: 4. 5 M€ 24 months 13 partners The seven core centers comprising INSTRUCT are: • Core A: University of Oxford, UK (Prof. Dave Stuart, Coordinator for INSTRUCT) - multi-disciplinary approaches. • Core B: CIRMMP Florence, Italy (Prof. Ivano Bertini) - NMR-based and integrated biophysical investigation of the structure and dynamics of biomolecules. • Core C: IGBMC Strasbourg, France (Prof. Dino Moras) - multi-scale structural biology of proteins, nucleic acids and their complexes. • Core D: The Weizmann Institute, Israel (Prof. Joel L. Sussman) multidisciplinary resource (X-ray/NMR/EM) for elucidation of structure and dynamics. • Core E: EMBL (Dr. Stephen Cusack) - provide integrated structural biology infrastructures, including synchrotron X-ray and imaging technologies. • Core F: MPI Munich, Germany (Prof. Wolfgang Baumeister) - broad expertise in high-resolution 3 D imaging, with unique strength in using cryo-electron tomography. • Core G: MPI Frankfurt, Germany (Prof. Hartmut Michel) - integrated biophysical and structural analyses of macromolecular complexes, 7 including membrane proteins.

ESFRI European Strategy Forum on Research Infrastructures ELIXIR: Upgrade of European Bioinformatics Infrastructure EC: ESFRI European Strategy Forum on Research Infrastructures ELIXIR: Upgrade of European Bioinformatics Infrastructure EC: 4. 5 M€ 38 months 32 partners www. elixir-europe. org ELIXIR will permit the integration and interoperability of diverse, heterogeneous, potentially redundant information that is essential to generate and utilize biological knowledge. It will encompass the necessary major computer infrastructure to store and organize this data in a way suitable for rapid search and access, and will provide a sophisticated and user-friendly portal for users. 8

ESFRI European Strategy Forum on Research Infrastructures Other • ESRF Upgrade (Analytical Facilities) Upgrade ESFRI European Strategy Forum on Research Infrastructures Other • ESRF Upgrade (Analytical Facilities) Upgrade of the European Synchrotron Radiation Facility Costs: 238 M, 83 M • EPOS (Environmental Sciences) Infrastructure for the study of tectonics and Earth surface dynamics Costs: 500 M, 80 M • LIFEWATCH (Environmental Sciences) Infrastructure for research on the protection, management and sustainable use of biodiversity Costs: 370 M, 71 M 9

Swedish research infrastructures ESFRI European Strategy Forum on Research Infrastructures & 10 Swedish research infrastructures ESFRI European Strategy Forum on Research Infrastructures & 10

Swedish research infrastructures - continued ESFRI European Strategy Forum on Research Infrastructures & & Swedish research infrastructures - continued ESFRI European Strategy Forum on Research Infrastructures & & & 11

ESFRI European Strategy Forum on Research Infrastructures Finland’s example 12 ESFRI European Strategy Forum on Research Infrastructures Finland’s example 12

ESFRI European Strategy Forum on Research Infrastructures Finland’s example 13 ESFRI European Strategy Forum on Research Infrastructures Finland’s example 13

ESFRI European Strategy Forum on Research Infrastructures Relevant current IL RI funding • ESRF, ESFRI European Strategy Forum on Research Infrastructures Relevant current IL RI funding • ESRF, funded by TELEM since 1999. Current annual funding (mostly by VATAT) is roughly 1 M euro. • Geant, internet infrastructure, funded by TELEM 1999 -2002. Ongoing funding by universities through IUCC (‘machba’). • ISRAGRID, novel e-infrastruture, funded by TELEM 2009 -2013. Will become part of european grid initiative. • EMBL+EMBC, funded by MOS. Annual costs 0. 9 M euro. Relevant to ELIXIR, the proposed EBI upgrade. • ESS, vatat funds $200 K*2 years. 14

ESFRI European Strategy Forum on Research Infrastructures Israel’s RI Roadmap • Israel’s strategy is ESFRI European Strategy Forum on Research Infrastructures Israel’s RI Roadmap • Israel’s strategy is being planned by VATAM, the Israel Committee for National Research Infrastructures • VATAM was established by MOLMOP, the Israel National Council for Research and Development • VATAM serves as an advisory board to governmental agencies (including TELEM) on questions regarding RIs. • MOLMOP has called for the establishment of a national fund dedicated to RI, aiming for annual expenditures of 100 M NIS. • VATAM has started a national RI survey, carried out by the Ne’eman institute of the Technion. This survey will serve as the basis for future planning of an RI roadmap. • See http: //horn. tau. ac. il/vatam. html for further information 15