ERA-NET Patho Geno Mics WP 2 Study on

ERA-NET Patho. Geno. Mics WP 2* Study on the programmes in third countries and existing international cooperations Inventory of pathogenomics-related programmes *Ina Keutmann Project Management Jülich I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Results Task 2. 1 • Who was included in the inquiry? • Methodology • Responses ERA-NET Partners/ Third Countries • Results sorted by Categories of national funding • Transnational Funding/ Cooperations • Summary I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Investigation in and outside Europe Inquiry through questionnaire sent via E-mail • 10 ERA-NET partner countries • 21 Third European countries • 16 Third countries outside Europe Questionnaire was sent to approx. 150 contacts* in approx. 40 countries (Feedback rate 8%) *(ministries, foundations, national institutes, academies, EU contacts (Cordis)) I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005 • Additional Identification of programmes and contacts by internet research • Collaboration of the International bureau, Bonn

ERA-NET Patho. Geno. Mics Questionnaire was sent to ERA-NET Partners on December 8 th ´ 04 Questionnaire concerning (inter-)national programmes: A 1: General Programme Information A 2: History and Road Map of the Programme A 3: Programme / Project statistics A 4: Research Content The ERA-NET Partners were kindly asked to send the completed questionnaire back until February 5 th 2005 Answers from 4 Countries are still missing… I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Returned Questionnaires Country Answer Returned National programmes Transnational programmes Austria Yes - - Finland Yes - Sweden France No Germany Yes * - Hungary No Israel Yes * - Latvia No Portugal No Slovenia Yes * - Spain Yes * - I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Countries included in this survey: + Programmes, Projects or Grants identified Austria France Liechtenstein Singapore Australia + Germany + Lithuania Slovenia + Belgium Greece Luxembourg Spain Brazil + Hungary Malta + South Africa Bulgaria India Mexico Sweden + Canada + Ireland + Netherlands + Switzerland + Chile Iceland New Zeeland + Taiwan + China + Israel + Norway + Turkey Cyprus Italy Poland UK + Denmark Japan + Portugal Vietnam + Estonia Korea + Rumania USA + Finland Latvia Russia I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Categories of national funding 1. (Genome-)Programmes that, among other topics, cover pathogenomic projects 2. National programmes, with pathogenomic related programme parts and larger projects that are part of a more general funding programme 3. Grants and Funds that cover pathogenomics related projects I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Results (Genome-)Programmes that, among other topics, cover pathogenomic projects and larger projects as part of a more general funding programme e. g. Canada 1. Genome Canada 2. Genomics of Human Pathogens and their Host Interactions 3. Immunochemistry Program I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Genome Canada • Established by the federal government in April 2000 • A not-for-profit corporation leading a national strategy on genomics and proteomics with $375 Mio in funding from the Government of Canada • Dedicated to developing and implementing a national strategy in genomics and proteomics research • Genome Canada has established 5 Genome Centres across the country • 2 running programmes focused on human pathogens I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Genome Canada Projects 1. Comparative and Functional Genomics of the Human Pathogen Cryptococcus neoformans Funding: Genome Canada (50%) Genome British Columbia (50%) Funding Envelope: total value : $ 2. 158. 557 (€ 1. 322. 040) Project goal: to identify the virulence mechanisms by which Cryptococcus causes disease in humans I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Genome Canada Projects 2. Genome wide Essential Gene Identification in Candida albicans and Applications to Antifungal Drug Discovery Funding: Genome Canada (50%) Genome Québec (50%) Funding Envelope: Total value: $ 5. 740. 927 (€ 3. 516. 114) Project Goal: to genetically dissect the organism to identify all essential genes to identify all drug targets I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics 2. Canadian Programme: Genomics of Human Pathogens and their Host Interactions The programme is part of the Genomics and Health Initiative (GHI) Funding: Provided by the Canadian Federal Government through the National Research Council (NRC) Duration of the programme: Original program (Genome Sciences in Infectious Diseases) 1999 to 2002 renewed in 2002 as the Genomics of Human Pathogens and their Host Interactions continued until March 2005 Funding Envelope: Budget from 1999 to 2005: $ 26 Mio (€ 15. 924. 077) Content: The objective was to apply new genomics tools to three human pathogens, Candida albicans, Francisella tularensis and Campylobacter jejuni. 8 running projects focused on human pathogens I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics 3. Canadian Programme: Immunochemistry Program Funding Organization: Canadian federal Government Running since 1929, with changing of the current foci of the research Actually 2 running projects focused on human pathogens: 1. Project Title: Molecular Pathogenesis 2. Project Title: Pathogen Genomics Details see report I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics (Genome-)Programmes that, among other topics, cover pathogenomic projects and larger projects as part of a more general funding programme e. g. USA: 1. Microbiology and Microbial Pathogenesis Programme 2. Large Scale Genome Sequencing Program includes “Pathogen Genomics” I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics 1. USA Programme: Microbiology and Microbial Pathogenesis Programme Owner: The National Institute for Dental and Craniofacial Research (NIDCR) (National Institute of Health, Department of Health and Human Services) Sequencing support since 1995 Funding Envelope: The goal is a success rate of 25% (by the end of the fiscal year NIDCR will have funded 25% of the research grant applications assigned to the institute) Actually 13 running sequencing projects focused on human pathogens I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics 2. USA Programme: “Pathogen Genomics” within the “Large Scale Genome Sequencing Program” Programme Owner: National Institute of Allergy and Infectious Diseases NIAID/ National Institute of Dental and Craniofacial Diseases NIDCR Running since September 1999 An Addendum to this programme has been released in 2000 by the NIAID together with the Defence Advance Research Project Agency. This addendum complemented the “Large Scale Genome Sequencing Program” by focussing on pathogens as pathogen agents for bioterrorism. 40 running sequencing projects focused on human pathogens estimated 10 additional projects in the field of pathogenomics No detailed information was available in concerning the funding envelope I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics National programmes, with pathogenomic related programme parts and larger projects that are part of a more general funding programme e. g. : Australia: China: Germany: Japan: Korea: Malta: Romania: Sweden: Switzerland: Taiwan: UK: Vietnam: I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005 Medical Bioinformatics, Genomics and Proteomics Programme Gene Manipulation Programme Infection and Inflammation Network National Bio. Resource Project Pathogenic Microorganisms Research for the Future Programme 21 st Century R&D Programme National RTDI Programme VIASAN – National programme of Biomedical research Functional analysis of the vag-gen family-a constitute of conserved genes among bacterial pathogens Antibiotic Resistance National Research Programme for Genomic Medicine Plant and Microbial Science Programme/ Agri-Food Programme National Programme on Biotechnology

ERA-NET Patho. Geno. Mics Germany Infection and Inflammation Network of the National Genome Research Network Programme Owner: German Federal Ministry for Education and Research First Phase started 2001, actual programme runs from 2004 to 2007 Funding: 15. 991. 668 € for the whole network 6. 539. 584 € (14 microbial pathogens projects) Content: The Infection and Inflammation Network of the NGFN has assembled scientific and clinical investigators of different backgrounds and comprises 9 work packages; 3 WPs are concerned with human pathogenic bacteria WP 1 Sepsis WP 2 Gastrointestinal infections WP 5 Tuberculosis The objective is to develop functional and comparative studies, into a molecular understanding of the human inflammatory response system in health and disease, thereby improving diagnostic and therapeutic options. 14 running projects focused on human pathogens (49 in total ) I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Switzerland “Antibiotic resistance” NRP 49 Programme Owner: Swiss National Science Foundation Duration of the programme: 1999– 2006 Funding Envelope: CHF 12 million (7. 763. 473 €) over a 5 - year period Content : - Scientific strategies of resistance monitoring - Survey of the current resistance situation - Determination of the degree of mobility of resistant bacteria and genes - Molecular studies on bacterial resistance - Social, legal, ethical and economic aspects ~ 5 -10 running projects focused on human pathogens (21 total) I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Romania The National Programme of Bio-medical research and Development “Life and Health” (VIASAN) Programme Owner: The Ministry of Education and Research (MEd. C) Running from 2001 -2006 Funding Envelope: About 2, 7 million € for the projects in the Genomics and Proteomics field, including both clinical and fundamental research Content: The VIASAN Programme includes four thematic fields of research: Immunology & Organ Transplant, Neuroscience, Cellular and Molecular Medicine and Genomics and Proteomics. 63 running projects for Genomics and Proteomics field I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Grants and Funds that cover pathogenomics related projects e. g. Ireland: Science Foundation Ireland grants Israel: Israel Scientific Foundation grants U. K. : The Wellcome Trust New Zeeland: Marsden Fund grants I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics United Kingdom Funding Organization: The Wellcome Trust (WT) 1. 1995 Set up of the Pathogen Sequencing Unit (PSU) to sequence the genomes of organisms relevant to human and animal health • PSU is now funded through the Sanger Institute • Main budget provided by the WT • Funding support of the Institute: 300 Mio £ (432 Mio € ) from 2001 to 2006 I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics United Kingdom Funding Organization: The Wellcome Trust (WT) 2. Ad hoc applications are accepted in all areas of pathogen research e. g. Project grants: 3 year-project grant awards £ 150 000 to £ 300. 000 (218. 277 - 436. 554 €) Programme grants: 5 year programme grant awards up to £ 1 200. 000 (1. 746. 217 €) I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Transnational Funding Europe Only one binational programme: MICMAN Partner countries: Finland – Sweden Organizations: Acadamy of Finland Swedish Foundation for Strategic Research (SSF) Duration of the programme: 01. 2003 – 31. 12. 2005 Main objective: -to increase the understanding and knowledge of the interaction between host and microbes - to apply this knowledge to the maintenance of health and to prevention and treatment of diseases I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics MICMAN Funding Envelope (1/2003 – 12/2005): The total budget of the programme: 5, 4 Mio € Academy of Finland: 4, 1 Mio € Swedish Foundation for Strategic Research: 1, 3 Mio € 15 research projects or consortia: 5 Finnish-Swedish consortia 2 Finnish consortia 8 individual Finnish projects. Altogether 26 research groups are funded in these projects/consortia I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Transnational Funding Special Programme for Research and Training in Tropical Diseases (TDR) Global Collaborative research grant “Pathogenesis and Applied Genomics” TDR is an independent global programme of scientific collaboration co-sponsored by United Nations Children's Fund (UNICEF) United Nations Development Programme (UNDP) World Bank World Health Organization (WHO) TDR depends on voluntary contributions from donors for most of its income. In 2004, contributing partners consisted of: 4 co-sponsors 23 governments 9 other (foundations, agencies etc. ) Total Budget for 2004: US$ 6. 614. 992, 00 (5. 122. 738 €) I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Special Programme for Research and Training in Tropical Diseases (TDR) “Pathogenesis and Applied Genomics” Duration: Established in 1975 The aim is to help coordinate, support and influence global efforts to combat a portfolio of major diseases of the poor and disadvantaged TDR supported international efforts to unravel the genomes of tropical parasites through five genome networks. Funding Research projects: Multicentre projects: I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005 up to US$ 35 000 per year for 2 years one-time renewal possible (27. 105 €) up to a total of US$ 70 000 per annum and for a 2 years (54. 210 €) The project must involve endemic country researchers (South-South or South-North collaborations)

ERA-NET Patho. Geno. Mics Transnational Cooperations European results Finland/ Sweden MICMAN Norway: The national functional genomics research programme in Norway (FUGE) Cooperation with Norwegian and foreign research groups Ireland: The Health Research Board works closely with partners in Northern Ireland, the United States and Europe . I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Transnational Cooperations Results Outside Europe Canada: Genomics of Human Pathogens and their Host Interactions formal collaborations with institutes and research groups in Europe and USA. The GHI Coordination Office considered this information confidential. - Immunochemistry Program “…international research collaborations are too numerous to list. “ Israel: German Israel foundation for Scientific Research and Development US Israel binational Science fund (BSF) Korea: “The 21 st Century Frontier R&D Program” includes foreign collaboration due to the problem of the shortage of home-grown talents Vietnam: National Program on Biotechnology Cooperations with Japan, UK, Australia, Germany I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics USA International Collaborations in Infectious Disease Research Program Projects in Cooperation with Universities of: • • • I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005 Bangladesh Brazil Chile Tanzania Colombia Egypt Gabon Gambia Ghana • • Kenya New Mexico Papua New Guinea Peru Salvador Shanghai South Africa Venezuela

ERA-NET Patho. Geno. Mics Summary • Pathogenomic related projects covered by unspecific programmes • Obviously most focused countries outside Europe: Canada and USA • Transnational pathogenomic activities on programme level are rare: In Europe only Finland Sweden • Most mentioned scientific contents have been questions on - The host pathogen interaction - The problem of resistance - Genome sequencing for further applications I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Summary • Pathogenomic related projects covered by unspecific programmes • Obviously most focused countries outside Europe: Canada and USA • Transnational pathogenomic activities on programme level are rare: In Europe only Finland Sweden • Most mentioned scientific contents have been questions on - The host pathogen interaction - The problem of resistance - Genome sequencing for further applications There is a big need for coordination activities! I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Thank you for your kind attention! Any Questions! I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Some Coffee or thee after the dry sheets? I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005

ERA-NET Patho. Geno. Mics Japan National Bio. Rsource Project "Pathogenic Microorganisms (Bacteria, Fungi and Protozoa)“ Part of the "Research Revolution 2002 (RR 2002) Programme Owner: Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) Running from 2003 -2008 No information on funding budget available Content: - research in infections and microorganisms - education of students in the control of infections - basic research for countermeasures against bioterrorism - providing of a systematic accumulation, storage and provision structure for nationally recognized bio resources ~ 24 central resource centres and an information centre are involved I. Keutmann, FZJ PTJ-BIO Bonn, April 7 th 2005