Скачать презентацию Epilepsy Surgery Neuroimaging Techniques Click to edit Скачать презентацию Epilepsy Surgery Neuroimaging Techniques Click to edit

92cd7067d51ee466a94a0741f48b5b6a.ppt

  • Количество слайдов: 9

Epilepsy Surgery & Neuroimaging Techniques Click to edit Master subtitle style By Morgan Hammick Epilepsy Surgery & Neuroimaging Techniques Click to edit Master subtitle style By Morgan Hammick BME 281, Section 2

The Brain Often compared to an organic computer There are 6 major divisions of The Brain Often compared to an organic computer There are 6 major divisions of the adult brain Contains roughly 20 billion neurons Contains almost 95% of the body’s neural tissue Averagely weights 1. 4 kg (3 lbs) Male brains are ~10% larger than females

Epilepsy A medical condition that produces seizures affecting a variety of mental and physical Epilepsy A medical condition that produces seizures affecting a variety of mental and physical functions 1 in 10 adults will have a seizure in their life time Seizures are classified into 2 groups Causes of seizures are further divided into 2 groups Symptomatic & Cryptogenic Acute & Remote 1990 - 70% cryptogenic and 30% remote

What Happens? 1. Non-invasive diagnostics 2. Electrode Implantation 1. 3. Based off suspected epileptogenic What Happens? 1. Non-invasive diagnostics 2. Electrode Implantation 1. 3. Based off suspected epileptogenic zone Brain Mapping 1. Using electrodes, MRI, EEG, and CT 2. Gives a better assessment of the risks and benefits of the resection surgery 4. Resection Surgery

Materials Types of electrodes Microwire electrodes Wires made of conducting metal coated with a Materials Types of electrodes Microwire electrodes Wires made of conducting metal coated with a non-cytotoxic insulator material. One array can consist of anywhere from 4 to over 100 wires Silicon-based electrodes Allow a more complex design and greater control over the electrode placement Unreliable for chronic recording in the CNS

Benefits Neuroimaging has revolutionized the care of patients More accurate diagnosis Reduced morbidity Benefits Neuroimaging has revolutionized the care of patients More accurate diagnosis Reduced morbidity

Risks There is always a risk with invasive EEGs Nonreversible brain damage About 1% Risks There is always a risk with invasive EEGs Nonreversible brain damage About 1% craniotomies Infection Memory Loss Partial Paralysis Surgery is only considered for patients who have no other options

Costs About 2 million people in the US have epilepsy $15. 5 billion in Costs About 2 million people in the US have epilepsy $15. 5 billion in direct & indirect costs $50, 000 - $200, 00 There are insurance companies that partially cover associated costs with epilepsy

Sources Martini, Frederic H. , Michael J. Timmons, and Robert B. Tallitsch. Sources Martini, Frederic H. , Michael J. Timmons, and Robert B. Tallitsch. "The Nervous System: The Brain and Cranial Nerves. " Human Anatomy. 7 th ed. Boston: Pearson Benjamin Cummings, 2012. 406. Print. "What Is Epilepsy. " Epilepsy Foundation of America, 2012. Web. 19 Oct. 2013. . “Causes of Epilepsy”. Epilepsy Foundation of America, 2012. Web. 19 Oct. 2013. . Taimouri, V. , A. Akhondi-Asl, X. Tomas- Fernandez, J. M. Peters, S. P. Prabhu, A. Poduri, M. Takeoka, T. Loddenkemper, A. M. Bergin, C. Harini, J. R. Madsen, and S. K. Warfield. "Electrode Localization for Planning Surgical Resection of the Epileptogenic Zone in Pediatric Epilepsy. " International Journal of Computer Assisted Radiology and Surgery (2013): n. pag. Abstract. Pub. Med (n. d. ): n. pag. Print. Polikov, V. , P. Tresco, and W. Reichert. "Response of Brain Tissue to Chronically Implanted Neural Electrodes. " Journal of Neuroscience Methods 148. 1 (2005): 1 -18. Print. Passaro, Erasmo A. "Neuroimaging in Epilepsy. " Neuroimaging in Epilepsy. Ed. Selim R. Benbadis. Medscape, 11 July 2013. Web. 20 Oct. 2013. . "Comprehensive Epilepsy Center. " Risks of Epilepsy Surgery. NYU Langone Medical Center, n. d. Web. 21 Oct. 2013. . "Epilepsy Surgery for Adults. " Epilepsy Action, n. d. Web. 20 Oct. 2013. . "Targeting Epilepsy. " Centers for Disease Control and Prevention, 06 June 2011. Web. 21 Oct. 2013. . "Epilepsy Surgery Facts. " One Fact One Fight For Epilepsy. N. p. , 21 June 2010. Web. 20 Oct. 2013. . Morace, Roberta, Giancarlo Di Gennaro, Angelo Picardi, Addolorata Macia, Giulio Meldolesi, Liliana Grammaldo, Pier Quarato, Vincenzo Esposito, Antonio Sparano, and Marco Risi. "Surgery after Intracranial Investigation with Subdural Electrodes in Patients with Drug-resistant Focal Epilepsy: Outcome and Complications. "Neurosurgical Review (2012): n. pag. Springer Link. Web. 21 Oct. 2013. .