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Effects of Cardiac Denervation on Development of Heart Failure and Catecholamine Desensitization by Naoki Effects of Cardiac Denervation on Development of Heart Failure and Catecholamine Desensitization by Naoki Sato, Stephen F. Vatner, You-Tang Shen, Raymond K. Kudej, Bijan Ghaleh-Marzban, Masami Uechi, Kuniya Asai, Israel Mirsky, Thomas A. Patrick, Richard P. Shannon, and Dorothy E. Vatner Circulation Volume 95(8): 2130 -2140 April 15, 1997 Copyright © American Heart Association, Inc. All rights reserved.

Responses of heart rate (top) and mean arterial pressure (bottom) to phenylephrine (5 μg/kg Responses of heart rate (top) and mean arterial pressure (bottom) to phenylephrine (5 μg/kg IV, left), nitroglycerin (5 μg/kg IV, middle), and intracardiac veratrine alkaloid (5 μg/kg, right) in intact dogs (open bars) and VD dogs (solid bars). Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Cardiac tissue NE levels in LVs and RVs in intact dogs (open bars) and Cardiac tissue NE levels in LVs and RVs in intact dogs (open bars) and VD dogs (solid bars) without (left) and with (right) heart failure. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Dose-response curves, ie, mean±SE percent increases in LV d. P/dt in response to NE Dose-response curves, ie, mean±SE percent increases in LV d. P/dt in response to NE in conscious intact dogs (○) and VD dogs ( • ), in the intact state (left) and in the presence of ganglionic blockade (right). Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

The sequential changes in LV d. P/dt and LV end-diastolic and end-systolic wall stresses The sequential changes in LV d. P/dt and LV end-diastolic and end-systolic wall stresses are shown 1 day, 7 days, and 3 to 4 weeks after pacing. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Vcfc is plotted against an index of afterload, ie, LV end-systolic wall stress. Naoki Vcfc is plotted against an index of afterload, ie, LV end-systolic wall stress. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Representative responses in LV pressure and d. P/dt, arterial pressure, left atrial pressure, and Representative responses in LV pressure and d. P/dt, arterial pressure, left atrial pressure, and heart rate during ISO infusion (0. 4 μg·kg− 1·min− 1) in an intact dog before (left) and after (right) heart failure. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Representative responses in LV pressure and d. P/dt, arterial pressure, left atrial pressure, and Representative responses in LV pressure and d. P/dt, arterial pressure, left atrial pressure, and heart rate during ISO infusion (0. 4 μg·kg− 1·min− 1) in a VD dog before (left) and after (right) heart failure. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during ISO Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during ISO infusion in intact dogs (left) and VD dogs (right) before (○) and after ( • ) heart failure. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during ISO Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during ISO infusion in intact (left) and VD (right) dogs before (○) and after ( • ) heart failure with constant pacing at 240 bpm. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during NE Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during NE infusion in intact dogs (left) and VD dogs (right) before (○) and after ( • ) heart failure. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.

Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during NE Dose-response curves for mean±SE changes in percent LV d. P/dt are shown during NE infusion in intact (left) and VD (right) dogs before (○) and after ( • ) heart failure with constant pacing at 180 bpm. Naoki Sato et al. Circulation. 1997; 95: 2130 -2140 Copyright © American Heart Association, Inc. All rights reserved.