Educating the Scientist Entrepreneur Stefano Fantoni SISSA Trieste

Educating the Scientist Entrepreneur Stefano Fantoni, SISSA Trieste

International School of Advanced Studies dynamic international Ph. D school scientific excellence new initiatives and projects interdisciplinary approach english language entreprenurial culture worldwide network spin-off companies

Connecting Scientific Ideas to Market

Social Network Models Business Models Open Cooperative and Community based Social Networks Concept Vs Structure Problems: security, intellectual property, privacy, hierarchy…

How to reach breakthrough innovations Short-circuiting scientists’ mindset to market needs and complexity will contribute to radical innovations in market processes and to the generation of new scientific paradigms. SCIENTISTS MANAGERS • entrepreneurial mindsets and attitudes • new approaches and educational models that • enable the capacity to understand markets and implementation complexity in the real world • learn from the traditional scientific approach • learn how to follow multiple pathways • work with global scale partners with complementary skills • better deal with complexity by mobilizing global social networks

Entrepreunership: recognize opportunity! Open, cooperative, and community based “Business” Models ------ Computer 1948 (ENIAC) Internet 1983 (TCP/IP) WWW 1980 (CERN) Electronic publications 1992 (SISSA) Citation Index => Link Ranking => Google 1996 (Stanford, Ph. D thesis) Web 2. 0 now …… future Scientists work at knowledge borderlines Entrepreneurs recognize opportunities and create new business models

DEMOCRITOS Mission Italian community for computer simulation at nano scale level. Theoretical a numerical support to chemistry and physics large-scale facilities. Ideal environment for innovative ideas in numerical simulations R&D in HPC methods and systems (parallel, cluster, and grid computing) Numbers 9 institutions (Universities, laboratories) 1 office in ELETTRA laboratory 4 research activities + 1 R&D service in IT 70 researchers (45 university researchers) 40 Ph. D students and 20 postdoc 4 amministrative employee 200 years cpu time / year >100 high impact publications / year www. democritos. it Research Computational nanoscience and materials engineering Computational biochemistry, biotechnology, and drug design Hard and soft condensed matter: superconductivity and disordered systems IT for computer simulations: software engineering, parallel, cluster, and grid computing

Democritos Catalysis Material Ethylene Epoxidation

QUANTUM ESPRESSO a world-wide connected project… Minneapolis MIT, Boston Paris Lausanne SISSA-Democritos, Trieste Princeton …for materials modeling at the nanoscale…. . . by computer simulations

Designing a new business model üThe guide-lines • open model • communitybased (QE) üThe core: • HPC/IT technologies • materials design OS project Scientific community üMarket approach • use the community • world-wide network Scientific accelerator Market …done…and to be done. . product evaluation competitors study market mapping financial analysis extend analysis in the future Developed by: S. Baroni, G. Chiarotti, S. Cozzini, S. Paolini

ICT at SISSA: e. Lab • • in collaboration with CNR/INFM Democritos National Simulation Center it leverages on the long standing experience in High Performance Scientific Computing developed so far. The term e-Science (or e. Science) is used to describe computationally intensive science that is carried out in highly distributed network environment. [from wikipedia] • The mission Maintaining a cutting-edge computational infrastructure for research groups at SISSA and DEMOCRITOS Plan and setup advanced solution for scientific and technical computing • • Software engineering Parallel computing (platforms & algorithms) Cluster computing (high-performance and distributed) Grid computing Enable technological transfer toward industry on the above theme Technology and products The activities • Cooperating with Eurotech on setting-up a HPC/Gridenvironment for SME in FVG (Mercurio. FVG as promoter) The proposal: • create a collaborative environment among research institution and industry • Setup of a common infrastructure • Identify industrial technical problems to run o on the infrastructure • Create “human capital”

Sissa Medialab's scholarly publishing activities date back to the early 1990's when, in the pre-Web era, SISSA set up the first electronic e-print service in Europe with the Babbage archive. Just a few years on, this was to trigger the idea of setting up JHEP (Journal of High Energy Physics) an online-only journal for high energy physicists that would revolutionise publishing habits in that community. Sissa Medialab is an active player in the arena of science communication to the general public, using different media aimed at different audiences, with a network of over 600 scientists. Using the web, Sissa Medialab reaches out to the general public – ranging from children to scientists – in order to impart scientific knowledge in a spirit of dialogue and debate.

Lubricant molecular structure

Neuro. Telemetry * Mathew E. DIAMOND, Erik ZORZIN, Igor PERKON SISSA - Cognitive Neuroscience Sector - Tactile Perception & Learning Laboratory http: //www. sissa. it/cns/tactile Neuro. Telemetry is a brain-computer interface device designed at SISSA, capable of capturing signals generated by neurons and transmitting them via radio to a remote computer using a wireless digital technology. … 0101010 0010101… Computer Neuron Fields of application: Clinic stimulation Audio technology Robotics Health monitoring * Patent Pending #PD 2006 A 000348

promoscience The experience of a university spin-off University Spin off PRODUCT/SERVICE DEVELOPMENT Product prototype Market driven customization Product introduction to the market Dissemination RESEARCH Publications Know-how Results Competencies Professors Researchers Students Global company + Innovation centers Public funds Consultants + promoscience experience: Competencies: - Information Retrieval Systems - Current Research Information Systems - Virtual Document Systems - GUI Design -… A Project Management tool to support the management of scientific projects A Content Management tool for scientific dissemination MARKET SEGMENT LEADERSHIP POSITION Product marketing Product updates Product differentiation ?

Glance Vision Tech. Srl PRODUCTS Innovative morphological analysis tool spin-off company established in 2005 Computer Vision & Machine Learning application: ROBOTICS (e. g. frame painting) Self-learning tool for analysis of biological images solid scientific background Research as the key factor for competitiveness face new problems in a possibly original way

Lay Line Genomics Italian private biotech company Focus on CNS (Alzheimer’s disease) and other neurological disorders (pain) Proprietary antibody- based technology platform constantly generating new therapeutic opportunities Novel animal models for neurodegenerative and aging-related diseases Pipeline of innovative compounds in advanced preclinical stage GET TO MARKET FASTER: FROM GENE TO ANTIBODIES The solution for the non invasive delivery of NGF to the brain The therapeutic concept that NGF might be used to slow or prevent cholinergic neuronal death in Alzheimer’s disease (AD) is an emerging theme, probably one of the most promising avenues to pursue. SPLINT is LLG proprietary platform for the selection of superior quality antibodies directly from gene sequences, with no requirement for protein expression, thus removing a severe bottleneck in the procedures for antibody isolation with other existing methods. After having obtained the first Po. C for a non invasive delivery of NGF to the brain, LLG has developed a proprietary form of NGF as a viable option to cure neurodegeneration.

SISSA-Elettra Nano Innovation Laboratory The Sissa-Elettra Nano Inovation Laboratory (SENIL) in collaboration with CBM is developing breakthrough technologies that aim at quantitative determination of gene expression single cell DNA analysis detection of protein biomarkers with ultra high sensitivity down to the subpicomolar concentration regime These new technologies are based on an our ability to measure molecular heights with unprecedented precision coupled to the ability to nanopattern soft materials on an equally unprecedented small scale.

Finance Portfolio Optimization Non standard Perturbed Gaussian Model for Portfolio Variance Optimization Better middle term returns! Developed by: C. Reina

Integrating Scientific Creativity, Enterpreunership and Business Processes Emerging technologies in IT, material science, biotech, energy idea generation and solution identification (physics, genetics, evolution, neurosciences) Five key themes Opportunity and potential customer needs and trends Implementation processes (project management, organization, operative flow, HR, mkt, ) Entrepreneurial, leadership, personal and team-working skills Developed by: G. Chiarotti, M. Fuccaro, P. Focher, E. Quadrelli, A. Sfiligoj

New paradigsm needed? […. . . ] the issue is whether we can succeed in developing new strategies for combining reductionist and holistic approaches in order to provide a meaningful bridge between molecular mechanism and mental processes: a true molecular biology cognition. If this approach is successful in the twenty first century, we may have a new, unified, and intellectually satisfying view of mental processes. CELL - Thomas D. Albright, Thomas M. Jessell, Eric R. Kandel and Michael I. Posner