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Discovery Park: A Paradigm for Interdisciplinary Research A. H. Rebar, DVM, Ph. D. Executive Discovery Park: A Paradigm for Interdisciplinary Research A. H. Rebar, DVM, Ph. D. Executive Director of Discovery Park and Senior Associate Vice President for Research

Discovery Park Integrated Centers An ideal center will excel in five dimensions… ü Quality Discovery Park Integrated Centers An ideal center will excel in five dimensions… ü Quality ü Economic development Burton D. Morgan Center for Entrepreneurship Birck Nanotechnology Center Bindley Bioscience Center ü Interdisciplinary Gerald D. and Edna E. Mann Hall ü Leverage ü Leadership Discovery Learning Center – to open 2009

President France A. Córdova Interim Provost William R. Woodson Dir. Sponsored Program Services Richard President France A. Córdova Interim Provost William R. Woodson Dir. Sponsored Program Services Richard O. Buckius Assoc. VPR & Dir. University Research Administration Vice President for Research OVPR/DP Business and Sponsored Programs Office Sr. Assoc. VPR & Exec. Dir. of Discovery Park Alan H. Rebar Assoc. VPR Research Development & Research Support Infrastructure

Founded 1961 2001 Purpose Start-up companies Interdisciplinary research Location Off-Campus US 52 Highway Main Founded 1961 2001 Purpose Start-up companies Interdisciplinary research Location Off-Campus US 52 Highway Main Campus State Street People 2878 employees ~1000 faculty members # Buildings 38 4 completed; 1 broke ground Sept. 2006 # Companies/Ce nters 2/15/08 Area 146 Companies 11 Centers 591 acres 40 acres

Core Centers ü Lilly Endowment support ü Institutional support ü Broad mission ü Synergism Core Centers ü Lilly Endowment support ü Institutional support ü Broad mission ü Synergism among centers • Bindley Bioscience Center • Birck Nanotechnology Center • Burton D. Morgan Center for Entrepreneurship • Center for Advanced Manufacturing • Center for the Environment • Cyber Center • Discovery Learning Center • e-Enterprise Center • Energy Center • Oncological Sciences Center • Regenstrief Center for Healthcare Engineering

Discovery Park Infrastructure • Administrative – Business team – SPS & Business Admin. – Discovery Park Infrastructure • Administrative – Business team – SPS & Business Admin. – Project coordination – Web site integration – Special events • Technical – Research Cores – partnership with academic units – Equipment and facilities

Project Based Centers Interdisciplinary in nature Affiliated with a core center Sponsored programs Often Project Based Centers Interdisciplinary in nature Affiliated with a core center Sponsored programs Often (NCN) NSF Network for Computation Nanotechnologyopportunistic Purdue Homeland Security Institute (PHSI) Purdue Climate Change Research Center (PCCRC) Purdue University Regional Visualization and Analytics Center (PURVAC) NEXTRANS (U. S. Dept. of Transportation Region 5 Transportation Center) Center for Catalytic Design (CCD) Product Life Cycle Management Center of Excellence Center for Prediction of Reliability, Integrity and Survivability of Microsystems (PRISM) Center for Authentic Science Practice in Education (CASPi. E)

New Initiatives • Center for Analytical Instrumentation Development (CAID) • Cytometry for Life (C New Initiatives • Center for Analytical Instrumentation Development (CAID) • Cytometry for Life (C 4 L) • Center for Assistive Technologies • DHS University Center of Excellence in Command, Control and Interoperability • Purdue Institute of Defense Innovation • Energy Frontier Research Centers

An Engine for Indiana’s Economy Industry Purdue Research Park Startup Company Licensing To Practice An Engine for Indiana’s Economy Industry Purdue Research Park Startup Company Licensing To Practice or Commercialization Project Ideas Educational or Training Concepts Seeding Nurturing Joint Venture Executing Discovery Park & University Infrastructure Cooperative Education Campus wide Value Proposition Discovery Park is designed to rapidly integrate Purdue with outside partners.

Alfred E. Mann Institute (AMI) at Purdue • Alfred E. Mann is a successful Alfred E. Mann Institute (AMI) at Purdue • Alfred E. Mann is a successful entrepreneur in the medical device field. • Created $1 B+ non-profit Alfred E. Mann Foundation for Biomedical Engineering (AEMFBE) • Mission is to expedite development of biomedical technologies at partner universities • Endowing $100 M+ non-profit Alfred E. Mann Institutes at partner universities (USC,

AMI Organizational Model • Operates under umbrella agreement with Purdue Research Foundation (PRF) to AMI Organizational Model • Operates under umbrella agreement with Purdue Research Foundation (PRF) to expand our technology commercialization capacity • Non-profit institute located in Purdue’s Discovery Park (DP) • Governed by Board comprised of half Purdue and half AEMFBE selected members • Uses ~$5 M endowment income for all operational costs (e. g. , rent, staff, resources)

AMI Organizational Model (cont. ) • Invests in and rapidly develops Purdue biomedical technologies AMI Organizational Model (cont. ) • Invests in and rapidly develops Purdue biomedical technologies • Licenses developed technologies to companies (startup through established) • Preference given to Indiana companies in order to fuel the local and regional economy • Income is shared among inventors, PRF, AMI, AEMFBE

AMI Chief Advantages • AMI will complete analysis on: – freedom to operate – AMI Chief Advantages • AMI will complete analysis on: – freedom to operate – barriers to market entry – time and cost to market – competitive technologies and market landscape – reimbursement strategies – regulatory approval processes – potential commercial partners • Immediate resources will be brought to bear on projects developed by AMI

AMI Chief Advantages (cont. ) • Thus, technology will be subsequently licensed to a AMI Chief Advantages (cont. ) • Thus, technology will be subsequently licensed to a company when: – technical risk is significantly reduced: • Working prototype(s) • Commercial scale demonstration • Preclinical and/or clinical studies completed • FDA approvals in process or granted – market application is well-defined • Result is a higher market value of the technology

Accomplishment: Sponsored Awards* ($M) Discovery Park Purdue system wide thru’ May 2008 Lilly End. Accomplishment: Sponsored Awards* ($M) Discovery Park Purdue system wide thru’ May 2008 Lilly End. 25 thru’ May 2008 Lilly End. 26 # awards: 6 21 56 111 188 224 210 3256 3294 3332 4076 3774 3131 3081 *Support in collaboration with Development is included. In addition, activity for awards to participating colleges/schools is included.

DP Accomplishment: Value Added Since August 2001 Equipment Office/Support Space Laboratory Space $17, 858, DP Accomplishment: Value Added Since August 2001 Equipment Office/Support Space Laboratory Space $17, 858, 825 Approx. 59, 000 sq. ft. Approx. 102, 000 sq. ft.

Funds from DP to Academic Units* Start-Up Contributions Cost Shares Equipment Grants Seeds Grants Funds from DP to Academic Units* Start-Up Contributions Cost Shares Equipment Grants Seeds Grants $5, 644, 000 1, 061, 404 964, 430 3, 709, 661 Miscellaneous (e. g. , summer grad 497, 865 support) TOTAL $11, 877, 360 *As of 2/2007. The total does not include costs of symposia, workshops, director salaries, administrative & business support for grant submissions, business plan competitions, Innovation Realization Laboratory/Technology Commercialization Laboratory, New Ventures Laboratory, CERIAS, EPICS Entrepreneurship Initiative, four endowed Directorships, DP Lectures Series, and other miscellaneous activities such as support of DP Research Cores in both personnel and equipment.

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Seeding 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Seeding and Nurturing Start-up Endocyte 14. VEM Smart Companies Systems, LLC Griffin Analytical Technologies 2 K Corporation Biovitesse Inc. Tienta Sciences Indigo Bio. Systems Prosolia Pri. Pro. Tex* Quadraspec, Inc. Data Tracking Solutions Theme Work Analytics** Brogan Phamaceuticals Advanced Radiotherapeutic Solutions* • Details of licensing are being worked out ** Non Purdue Technology 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. M 4 Corporation Mag. Sense Life Sciences Matrix. Bio, LLC Prima Specialty Vectors Stormfront Productions** Plus six Identity Alliance** start-ups Cytometry for Life** by Interns Al. Gal. Co** for Indiana Kylin Therapeutics, Inc. program National Institute of students Pharmaceutical Technology

Strategic Plan October 2003 In 2006, Discovery Park had: • 5 new interdisciplinary ü Strategic Plan October 2003 In 2006, Discovery Park had: • 5 new interdisciplinary ü 5 new interdisciplinary research • 3000 students in ü 3000 students in entrepreneurial research buildings • entrepreneurial activity 500 faculty involved in interdisciplinary research buildings activity ü 1000 faculty involved in interdisciplinary research • $25 million/year in sponsored ü $44 million/year in sponsored research funding • 8 new start-up companies • 20 corporate partners research funding ü 20 new start-up companies facilitated in cooperation w/Purdue Research Fdn. ü 20 corporate partners

(GE 3 NIE): Generating Entrepreneurs, Entrepreneurial Ecosystems, and Networks for Indiana’s Economy: A Discovery (GE 3 NIE): Generating Entrepreneurs, Entrepreneurial Ecosystems, and Networks for Indiana’s Economy: A Discovery Park Super Project …in partnership with – the Purdue Research Foundation – the Purdue Office of Engagement – and other organizations/institutions …will develop and implement a series of programs – to enhance IP commercialization – to promote a culture of entrepreneurship throughout the state The outcome will be an Indiana Entrepreneurial Ecosystem.

National and International Partnerships • Energy • Australia crisis • China • Global warming National and International Partnerships • Energy • Australia crisis • China • Global warming • India • Israel • Healthcare delivery • Puerto Rico • Homeland security • Korea Signing of Memorandum of Understanding between Purdue University and the Department of Science and Technology, Government of India • Learning

WOW by 2012 q Building facilities for an additional five core centers q $100 WOW by 2012 q Building facilities for an additional five core centers q $100 million in annual sponsored funding q Thirty additional start-ups assisted and facilitated q Fifty new patent applications based on Discovery Park research q Ten new nationally recognized project centers and institutes q Twenty new partnerships with global institutions

Video Clips DP Overview Biotechnology and Nanotechnology Healthcare Video Clips DP Overview Biotechnology and Nanotechnology Healthcare

It IS happening here!! For information on Discovery Park: http: //www. purdue. edu/discoverypark Dr. It IS happening here!! For information on Discovery Park: http: //www. purdue. edu/discoverypark Dr. A. H. Rebar, (765) 496 -6625; [email protected] edu