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Director’s Report to the National Advisory Council on Drug Abuse May 22, 2003 Director’s Report to the National Advisory Council on Drug Abuse May 22, 2003

Glen R. Hanson, Ph. D. , D. D. S. Acting NIDA Director December 1, Glen R. Hanson, Ph. D. , D. D. S. Acting NIDA Director December 1, 2001 to April 30, 2003 Thank you Glen!! Associate Director for Neuroscience and Translation

What’s My Background? M. D. from National University of Mexico Residency in Psychiatry at What’s My Background? M. D. from National University of Mexico Residency in Psychiatry at New York University 20 Years Working in Addiction Research Prior to Becoming NIDA Director… Associate Director for Life Sciences, Brookhaven National Laboratory (BNL) Chairman, Medical Department, BNL Director of Nuclear Medicine, BNL Director of the NIDA-DOE Regional Neuroimaging Center at BNL Professor, Department of Psychiatry, SUNY-Stony Brook Associate Dean for the Medical School, SUNY-Stony Brook

Brookhaven PET Group DOE/NIDA F. Telang, R. Mac. Gregor, P. Carter, D. Schlyer, C. Brookhaven PET Group DOE/NIDA F. Telang, R. Mac. Gregor, P. Carter, D. Schlyer, C. Shea, J. Gatley, S. Dewey, C. Redvanly, P. King L. Caligiuri, G-J Wang, M. Franceschi, Y-S Ding, J. Logan, N. Volkow, J. Fowler, R. Ferrieri, C. Wong (not shown) D. Alexoff, C. Felder, N. Pappas, D. Franceschi, N. Netusil, V. Garza, R. Carciello, D. Warner, M. Gerasimov

Dopamine D 2 Receptors are Lower in Addiction DADA DA Cocaine DA D 2 Dopamine D 2 Receptors are Lower in Addiction DADA DA Cocaine DA D 2 Receptor Availability DADA Alcohol Heroin control addicted DA DA DA Reward Circuits Non-Drug Abuser DADA DA DA Reward Circuits Drug Abuser

As NIDA Director… Some of the Research Areas I Intend To Address Include: Vulnerability As NIDA Director… Some of the Research Areas I Intend To Address Include: Vulnerability to Addiction (Impact of Genetic and Environmental Influences) Prevention Research (Children and Adolescents) Treatment Interventions

Recent NIDA Staff Appointments/Changes Office of Science Policy and Communications (OSPC) Lucinda Miner, Ph. Recent NIDA Staff Appointments/Changes Office of Science Policy and Communications (OSPC) Lucinda Miner, Ph. D. – Deputy Director, OSPC Division of Epidemiology, Services and Prevention Research (DESPR) Beverly Pringle, Ph. D. – Deputy Chief, Services Research Branch, DESPR Center for the Clinical Trials Network (CCTN) Karla Moras, Ph. D Division of Treatment Research & Development (DTR&D) Mary Ann Stephens, Ph. D. Office of Extramural Affairs (OEA) Eliane Lazar-Wesley, Ph. D.

Director’s Report to the National Advisory Council on Drug Abuse What’s New at NIH? Director’s Report to the National Advisory Council on Drug Abuse What’s New at NIH? Budget Update Recent NIDA Activities FY 2004 and Beyond

What’s New at NIH? What’s New at NIH?

THE NIH ROADMAP An Agency-Wide Effort To Identify the Critical Roadblocks and Knowledge Gaps THE NIH ROADMAP An Agency-Wide Effort To Identify the Critical Roadblocks and Knowledge Gaps That Constrain Rapid Advances in Biomedical Research Progress

NIH Roadmap RE-ENGINEERING THE CLINICAL RESEARCH ENTERPRISE NATIONAL CLINICAL RESEARCH NETWORKS Form a sustained, NIH Roadmap RE-ENGINEERING THE CLINICAL RESEARCH ENTERPRISE NATIONAL CLINICAL RESEARCH NETWORKS Form a sustained, efficient infrastructure Rapidly initiate large clinical trials Rapidly move effectiveness data into the community THEMES NEW PATHWAYS TO DISCOVERY Provide information to patients, families & advocacy groups GOALS RESEARCH TEAMS OF THE FUTURE TRANSLATIONAL RESEARCH INFRASTRUCTURE INTEGRATED, MULTIDISCIPLINARY & DIVERSE WORKFORCE

NIH Roadmap Initiatives New Pathways to Discovery New Approaches Building Blocks for Biology Biological NIH Roadmap Initiatives New Pathways to Discovery New Approaches Building Blocks for Biology Biological Pathways and Networks Nancy Pilotte Regenerative Medicine Barry Hoffer Technologies Structural Biology Bioinformatics & Computational Biology Molecular Libraries Glen Hanson & David Shurtleff Nanotechnology Molecular Imaging Nora Volkow (Co-chair)

NIH Roadmap Initiatives Research Teams of the Future Multi-disciplinary Research Teams Wilson Compton Public/Private NIH Roadmap Initiatives Research Teams of the Future Multi-disciplinary Research Teams Wilson Compton Public/Private Partnerships Glen Hanson & Frank Vocci High-risk Research Teri Levitin Re-engineering the Clinical Research Enterprise Translational Research Glen Hanson & Bill Corrigall Integrated Clinical Research Networks Don Vereen Clinical Research Workforce Training Clinical Research Informatics

Budget Update Budget Update

NIDA BUDGET (Thousands) 2001 Actual 2002 Actual 2003 Estimate 2004 P. B. Non. AIDS NIDA BUDGET (Thousands) 2001 Actual 2002 Actual 2003 Estimate 2004 P. B. Non. AIDS $537, 075 $606, 830 $660, 109 $680, 603 AIDS $245, 397 $278, 372 $301, 612 $315, 011 TOTAL Increase Over Prior Year $782, 472 $885, 202 $961, 721 $995, 614 +12. 2% +13. 1% +8. 6% +3. 7%

Recent NIDA Activities Recent NIDA Activities

Highlights of Recent Meetings and Events Highlights of Recent Meetings and Events

The th 7 Annual PRISM Awards May 8, 2003 The th 7 Annual PRISM Awards May 8, 2003

To Commemorate Brain Awareness Week At NIH To Commemorate Brain Awareness Week At NIH

In Memory of Dr. Roger Brown Associate Director for Neuroscience Division of Neuroscience and In Memory of Dr. Roger Brown Associate Director for Neuroscience Division of Neuroscience and Behavioral Research, NIDA

Beyond the Clinic Walls: Expanding Mental Health, Drug & Alcohol Services Research Outside the Beyond the Clinic Walls: Expanding Mental Health, Drug & Alcohol Services Research Outside the Specialty Care System Sponsored by: NIMH, NIDA & NIAAA March 10 -12, 2003

Recent Meetings/Events Stem Cells: Opportunities for Drug Abuse Research? Smoking Cessation Pharmacotherapy: Accelerating Discovery Recent Meetings/Events Stem Cells: Opportunities for Drug Abuse Research? Smoking Cessation Pharmacotherapy: Accelerating Discovery to Delivery (with NCI and NIAAA at SRNT) Smoking Cessation in Opioid Dependent Patients Workshop (at AATOD Meeting) Dr. Lonnie E. Mitchell National HBCU Substance Abuse Research Conference (Co-sponsor) First Annual Cyber. Therapy Conference (Co-sponsor) Drug Use and Suicidal Behavior Drug Abuse As A Gender Issue (at ASPET Meeting) Special Event Program at (SRCD) Effectiveness of NIDA’s Public Information Publications Advisory Panel CTN National Steering Committee Meetings January 25 -30, 2003 – Miami, FL March 23 -28, 2003 – Albuquerque, NM

New Program Announcements (PAs) and Requests for Applications (RFAs) Issued With Other NIH Components New Program Announcements (PAs) and Requests for Applications (RFAs) Issued With Other NIH Components DA I e ut tit e ns bus I al A on ug ati Dr N on N

New PAs With Other NIH Components Planning Grants to Organize Programs for International Clinical, New PAs With Other NIH Components Planning Grants to Organize Programs for International Clinical, Operational and Health Services Research Training for AIDS and Tuberculosis (PAR-03 -073) Centers for AIDS Research: D-CFAR, CFAR (PAR-03 -089) Gene Discovery for Complex Neurological and Neurobehavioral Disorders (PAS-03 -092) (with NINDS, NIA and National Institute of Environmental Health Sciences (NIEHS)) Research on Children Exposed to Violence (PAR-03 -096) Innovations in Biomedical Computational Science and Technology (PAR-03 -106) NIH Small Research Grants Program (R 03) (PA-03 -108) NIH Exploratory/Developmental Research Grant Award (R 21) (PA-03 -107)

New RFAs With Other NIH Components Clinical Research Education and Career Development (CRECD) in New RFAs With Other NIH Components Clinical Research Education and Career Development (CRECD) in Minority Institutions (RR-03 -007)

DHHS NIH SAMHSA NIDA Translate Research Findings Into Relevant Clinical Practice DHHS NIH SAMHSA NIDA Translate Research Findings Into Relevant Clinical Practice

NIDA/SAMHSA Science to Services Efforts NIH Grant Writing Technical Assistance NIDA Funding the Center NIDA/SAMHSA Science to Services Efforts NIH Grant Writing Technical Assistance NIDA Funding the Center for Substance Abuse Treatment’s (CSAT) Addiction Technology Transfer Centers (ATTC) and the Center for Substance Abuse Prevention’s (CSAP) Community Coalitions Analysis NIDA Providing Implementation-Ready Interventions to CSAT and CSAP Co-funding NIDA’s: Criminal Justice Initiative Multisite Community Prevention Trials Linking NIDA and CSAT Grant Programs

FY 2004 and Beyond FY 2004 and Beyond

Division of Neuroscience and Behavioral Research (DNBR) 5 -Year View Transdisciplinary Approaches New Technology, Division of Neuroscience and Behavioral Research (DNBR) 5 -Year View Transdisciplinary Approaches New Technology, Models, Paradigms Genetics/Vulnerability and Developmental Processes

DNBR New Initiatives Tobacco Addiction Proteomics Adolescents and Drug Abuse Relapse DNBR New Initiatives Tobacco Addiction Proteomics Adolescents and Drug Abuse Relapse

Division of Treatment Research and Development (DTR&D) 5 -Year View Shift in Medications Development Division of Treatment Research and Development (DTR&D) 5 -Year View Shift in Medications Development Efforts from Opiates to Stimulants and Nicotine Foster Relationships With Pharmaceutical Industry Revive Medical Involvement in Drug Abuse Treatment New Directions for Behavioral Therapy Development

DTR&D New Initiatives Access to Chemical and Molecular Libraries Integration of HIV & Infectious DTR&D New Initiatives Access to Chemical and Molecular Libraries Integration of HIV & Infectious Disease Risk Reduction Interventions into Behavioral Treatments Neurodevelopment/Pediatric Neuroimaging Translational Brain Imaging Centers

Division of Epidemiology, Prevention and Services Research (DESPR) 5 -Year View Services System Studies Division of Epidemiology, Prevention and Services Research (DESPR) 5 -Year View Services System Studies for Prevention and Treatment In Order to Improve Public Health Outcomes (i. e. Science to Service Programs) Environment-Gene Interaction Studies Transdisciplinary Research: Applying Concepts and Methodologies from Allied Fields to “Real Settings” Public Health Research (e. g. Behavioral Economics and Neuroscience)

DESPR New Initiatives Prevention and Treatment of Drug Abuse in Primary Care Settings Novel DESPR New Initiatives Prevention and Treatment of Drug Abuse in Primary Care Settings Novel Approaches to Phenotyping Drug Abuse Prevention Programs Aimed at Young Adults Family-Based Prevention Systems

Center on AIDS and Other Medical Consequences of Drug Abuse (CAMCODA) 5 -Year View Center on AIDS and Other Medical Consequences of Drug Abuse (CAMCODA) 5 -Year View Better HIV/Drug Use Epidemiology and Prevention Studies Tailor HIV Treatment for Drug Abusers (Ethnicity, Gender, Culture) Drug Interaction International Research

CAMCODA New Initiatives Hepatitis C Research Longitudinal Effects of Drug Use in Children International CAMCODA New Initiatives Hepatitis C Research Longitudinal Effects of Drug Use in Children International HIV/AIDS Prevention and Drug Abuse Treatment, Caribbean and China Women’s Health Research

Center for the Clinical Trials Network (CCTN) 5 -Year View Refinement of CTN’s Infrastructure Center for the Clinical Trials Network (CCTN) 5 -Year View Refinement of CTN’s Infrastructure and Mission Increase the Use of the CTN As A Platform for Training Enhance the Use of the CTN As A Platform for Additional Types of Research (Medications Development; HIV Prevention; Genetic Studies) Development of Clinical Practice Guidelines Revive Medical Involvement in Drug Abuse Treatment

We Want Council’s Input! 1. Blue Ribbon Task Force 2. CTN 3. CAMCODA We Want Council’s Input! 1. Blue Ribbon Task Force 2. CTN 3. CAMCODA