Development of versatile test platforms for research of

Development of versatile test platforms for research of radiation detectors for medical applications O. Bezshyyko (TSNUK), S. Fomin (Kh. NU), L. Davydov (NSC KIPT) STCU project ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017)

Ukrainian teams (Participating Institutions): § § § Taras Shevchenko Kyiv National University of Ministry of Education and Science of Ukraine (TSNUK) V. N. Karazin Kharkiv National University of Ministry of Education and Science of Ukraine (Kh. NU) National Science Center "Kharkiv Institute of Physics and Technology" of National Academy of Sciences of Ukraine (KIPT) Kyiv Institute for Nuclear Research NASU of National Academy of Sciences of Ukraine (KINR) Institute of Applied Physics NASU of National Academy of Sciences of Ukraine (IAP) The project is financed by EU together with CNRS and National Universities in Kiev and Kharkov Under the auspices of LIA IDEATE France-Ukraine International Associated Laboratory (LIA) “Instrumentation Developments for Experiments at Accelerator facilities and accelerating TEchniques” (IDEATE) ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 2

Ukrainian teams propose: Development of comprehensive set of experimental techniques and versatile test platforms in the Universities for development, characterization and testing of a wide range of radiation detector systems for medical imaging, beam and dose monitoring and other medicine applications. The developed platforms will serve for training students and specialists in medical imaging devices. Construction & operation of the platforms will be assisted by the CNRS (LAL) via the LIA program Kyiv: TSNUK, KINR Sumy: IAP ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) Kharkiv: KNU, KIPT 3

Kyiv platform TSNUK (Kyiv University) Responsibility – Oleg Bezshyyko § § Test subplatform for studies of MPGD detectors with automated systems of gas control and power supply, data acquisition system, mechanical sub-system. Micro Time Projection Chamber (TPC) on the base Micromegas/Ingrid chip using subplatform for studies of MPGD detectors. Test subplatform for silicon photodetectors using Geiger mode – Si. PM with automated systems of positioning and temperature control of conditions. A small prototype for 3 D printing system to print complex structures of anthropomorphic phantoms with using of various dose detector systems. Open source RTPS (Radiation Therapy Planning Systems). ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 4

Applications of MPGD in medicine Portal Imaging Simple X-ray imaging system and system for a medical application as a proton beam monitor Application of Micromegas in medical ion transmission tomography Fast and thermal neutron detection Possible collaboration with RD 51 (CERN) for further developments ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 5

Possible applications of Si. PM in medicine Development of Si. PM-based gamma camera, full-body SPECT Ultra precise timing with Si. PM-Based TOF PET scintillation and Cherenkov detectors Prompt gamma camera for real-time range control in Proton Therapy; dose distribution in real time for ion beam therapy by means of prompt gamma detection; prompt gamma imaging with a slit camera PET/MR System With Time-of-Flight Capability Depth Of Interaction (DOI) determination SIPMED camera ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 6

Anthropomorphic phantoms Radiation Therapy Phantoms ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 7

Planning systems for dose calculations for radiation oncology RTPSs Commercial RTPSs (Pinnacle, Xi. O, Eclipse, TMS, Kon. Rad, i. Plan etc. ) – are very power systems but also very expensive and tied strongly to a specific manufacturer equipment. It restricts firmly possibilities for effective education of new personal, students in universities (medical physics, clinical dosimetry specialties…), providing of second calculation path to estimate the dose obtained by patient (requirements of regulation documents). Open Source functional RTPS – solution of this problem Calculation algorithms and methods - Monte Carlo method (fast variants), Semi-Empirical algorithms (also called Correction or Factor based) -> model based algorithms, Pencil Beam algorithm (Convolution), Convolution. Superposition algorithms… ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 8

Kyiv platform Kyiv Institute for Nuclear Research of NASU Responsibility – Fedor Danevich § § Low background scintillation spectrometer to measure low level radioactivity in crystal scintillators and in samples of materials High performance radiopure Cd. WO 4, Zn. Mo. O 4, Li 2 Mo. O 4, Zn. WO 4 crystal scintillators. Responsibility – Valery Pugatch § § Development of detectorized phantom prototypes for dose delivery verification (heavy-ion radiotherapy in oncology) Tests of the detectorized phantoms at different radiation facilities ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 9

Low background scintillation spectrometer to measure low level radioactivity in crystal scintillators and in samples of materials Collaboration with CSNSM, Orsay, France Production of high quality 186 g Li 2100 Mo. O 4, 1303 h in EDELWEISS set-up at the Modane underground Lab zinc (Zn. Mo. O 4) and lithium molybdate (Li 2 Mo. O 4) crystal scintillators (including 2 2 , 100 Mo Li 2 Mo. O 4 53 mm scintillators from enriched 100 Mo) has been developed High performance Li 2100 Mo. O 4 scintillating bolometers: • Energy resolution FWHM = 4 -6 ke. V at 2615 ke. V • Particle discrimination capability: • DP / = 9 – 18 Low radioactive contamination: < 10 Bq/kg of 226 Ra and 228 Th An important physical result: the most accurate T 1/2 of 100 Mo [1] E. Armengaud et al. , Development of 100 Mo-containing scintillating bolometers for a high-sensitivity neutrinoless double-beta decay search submitted to EPJA ; ar. Xiv: 1704. 01758 v 2 [physics. ins-det] 4 Oct ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 2017 10

High performance radiopure Cd. WO 4, Zn. Mo. O 4, Li 2 Mo. O 4, Zn. WO 4 crystal scintillators • 20 enriched Li 2100 Mo. O 4 crystals are produced • Assembling of the Li 2100 Mo. O 4 detectors is in progress aiming to start a pilot experiment beginning of 2018 Assumed background is 10− 3 counts/yr/kg/ke. V in 10 ke. V window centered at Q 2 of 100 Mo: Sensitivity to 0 2 decay of 100 Mo over 6 month: • Production of the next 20 Li 2100 Mo. O 4 detectors is foreseen in 2018 Sensitivity with 40 detectors over 3 yr: ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 11

ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 12

ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 13

Kyiv platform Institute of Applied Physics of NASU (Sumy) Responsibility – Dmitry Nagorny § § A prototype detector based on multisensor array and focused on study of X-ray phase contrast. Testing of the detector at the channel quasi-monochromatic X-ray end-station at the IAP NAS of Ukraine. ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 14

Multimatrix X-Ray detector for phase contrast imaging experiments Basic parameters Sensitive Area Optical Configuration DQE(0) Optical Resolution Dynamic Range Energy of detected X-Ray quantum Frame rate External digital interface 90 x 60 mm 2 x 2 cells 0. 44 up to 12 pl/mm equal to 14 bits 9 -100 ke. V (for different conversional screens) 15 -150 FPS Gigabit Ethernet Optical scheme of the detector 3 D CAD Driwing of the Multimatrix Hybrid X-Ray Detector ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) Multimatrix Hybrid X-Ray Detector 15

Accelerator based compact source of quasi-monochromatic X-ray at IAP NASU A selected single-shot radiograph dominated by X-ray 3 D model and a general view of the in-line phase contrast. quasimonochromatic X-ray source with ion exitation ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 16

Kharkiv platform V. N. Karazin Kharkiv National University Responsibility – Serquei Fomin § Specific software code for Cd. Zn. Te dosimeter The objective Development and characterization of Cd. Zn. Te detectors for the application in dosimetry of X- and gamma-radiation Expected results Specific software code for Cd. Zn. Te dosimeter allowing for an analysis of the X-ray spectra will be written, verified and tested ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 17

Kharkiv platform National Science Center KIPT of NASU Responsibility – Nikolai Maslov § Microwire bonding facilities and automated facilities for detector testing will be developed and created. § A single-channel double-sided silicon photosensor with its separated photosensitive and signal output functions will be realized and investigated. A scintillatorphotosensor assembly will be manufactured. The spectrometric read-out system will be developed and manufactured. Responsibility – Vladymir Kutny § CVD polycrystalline and single crystal diamond prototype detectors. § A prototype dosimetric device in which for precision measurements of the dose (dose rate) statistical parameters of gamma-radiation spectra will be used. ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 18

Development of microwire bonding facilities and automated facilities of detector testing Expected results Microwire bonding facilities and automated facilities for detector testing will be realized on the basis of the available facilities at KIPT and with the additionally purchased equipment. The created facilities will allow to perform a full cycle of manufacturing and automated testing of research silicon detector systems. Besides, they will allow training students in modern instrumentation and process equipment. Double-sided (two-coordinate) microstrip detector (DSMD), produced in KIPT Double-sided (two-coordinate) microstrip detector (628 channels on each side ), constructed by Kharkiv group for HEP ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) Microstrip detector in the test station with the microprobes 19

Single-channel and double-sided Si photosensors Expected results A single-channel double-sided silicon photosensor with its separated photosensitive and signal output functions will be realized and investigated. Usingle-channel double-sided Si photosensor a scintillator-photosensor assembly will be manufactured. The spectrometric read-out system will be developed and manufactured. Single-channel single-sided silicon spectrometer detector Measurement of radiation of isotope source 241 Am using Single channel silicon detector for roomuncooled detector. The energy resolution of 1. 16 ke. V. temperature spectrometry Preamplifier with resistive feedback. ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 20

CVD polycrystalline & single crystal diamond prototype detectors Expected results CVD polycrystalline and single crystal diamond prototype detectors will be manufactured. Their parameters and properties will be investigated and irradiation tests under X-ray and electron and proton beams will be conducted. Polycrystalline diamond film grown on a silicon substrate Interdigitated Al contacts on the growth surface of the diamond film Their compliance with the requirements for external beam radiotherapy detectors will be determined. The response to proton beam will also be investigated. Calibration of diamond detector in X-ray radiation field HPHT diamond crystals of detector quality (2 -3 mm), Kiev L. N. Davydov, et al. . SPIE Proceedings, Vol. 8507, p. 85071 N-1, 2012. V. E. Kutny, et al. , Problems of atomic science and technology. No. 3(91), (62), 2014. p. 162. ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 21

A dosimetric device for precision measurements of the dose (dose rate) Expected results A prototype dosimetric device will be created, in which for precision measurements of the dose (dose rate) statistical parameters of gammaradiation spectra will be used. Wide-range γ-ray dose rate detector module Calibration characteristics of the commercial detector module BDMG-41 compared to detector module BDRG-T with Cd. Zn. Te detector. A. V. Rybka et al. Nucl. Instr. & Meth. A, 2004, vol. 531, pp. 147 -156. A. Zakharchenko et al. Proc. SPIE, Vol. 8507, Paper 85071 I, 2012. A. A. Zakharchenko et al. // Proc. SPIE, Vol. 8852, Paper 88521 B, 2013. ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) Relation between Cd. Te and Cd. Zn. Te detector sensitivities and average amplitude of pulses created in detectors at the registration of gamma-quanta. The technique of calibration and metrological tests of the developed dosimeter will be developed. 22

Thank you for your attention! ERDIT Meeting at Synchrotron SOLEIL, Paris, France (9 -10 November 2017) 23