Current Research Paradigm at Most Academic Cancer Centers

Current Research Paradigm at Most Academic Cancer Centers

Traditional Cancer Prevention Activities at Academic Cancer Centers (2)

Prevention Provides Greatest Impact on Wide Variety of Diseases

Heart disease provides an excellent example of successful prevention

Epidemiology Describes Four Levels For Cancer Prevention

Inherited Gene Defects Do Not Explain All Cancer Risk

Academic Cancer Centers Can Develop More Effective Cancer Prevention Strategies (1)

Academic Cancer Centers Can Develop More Effective Cancer Prevention Strategies (2)

Academic Cancer Centers Can Develop More Effective Cancer Prevention Strategies (3)

Cancer Prevention at UPCI

What is ‘Environmental Oncology? ’

Center for Environmental Oncology (CEO)

Four Divisions of the Center for Environmental Oncology

CEO Areas of Emphasis

Evidence Supporting Environmental Exposure as a Cause of Cancer

Jobs With Increased Risk of Breast Cancer

Exposure Risk Assessment and Precaution Pediatric Head CT Scans-2008

Long-term Cell Phone Use and Brain Tumor Risk Suggestive but not Definitive Data

Cell Phone Radiation is Absorbed More Deeply Into the Brains of Children

Hypothesis: If the long term use cell phone studies are correct in pointing to increased risk for brain tumors, the incidence of brain tumors should be increasing, particularly in children and young adults

SLER Registries for GLIOMAS age-specific incidence, 0 -39 years of age

Exposure Risk Assessment and Precaution 0 n Cell Phones; Follow up

Biological Effects of Environmental Xenoestrogens

Biochemoprevention Program University of Pittsburgh Cancer Institute

Inhibition of PC-3 Xenograft Growth by Garlic-derived Diallyl Trisulfide (DATS) DATS (5 μmol) was given orally three times/week *P < 0. 05 by Student’s t-test. Shivendra Singh

Resveratrol prevents experimental cancer

Chemoprevention to Stop Progression of Premalignant or Stage 0 Lesions

Biomarkers Being Evaluated in Study of Celecoxib for Prevention of Breast Cancer

Rationale

Meta-analysis: Muc 1 Immunotherapy in CRC

Why Study Advanced Adenoma?

Objectives

Serum and Tissue-based Biomarker Discovery -- Needs

Biomarker Discovery at UPCI

SERUM vs. URINE IN OVARIAN CANCER Anna Lokshin

ROC curve for classification of endometrial cancer