CPE Singapore-MIT Alliance-2 Programme in Chemical Pharmaceutical

CPE Singapore-MIT Alliance-2 Programme in Chemical & Pharmaceutical Engineering Overview (2006 -2014) 1

CPE World Class Faculty Programme Co-Directors Singapore MIT Rajagopalan Bernhardt L. Trout Head of the Department of Chemical and Biomolecular Engineering, NUS Associate Professor of Chemical Engineering, Massachusetts Institute of Technology Research: _ colloid physics _ polymer/colloid interactions _ Micellization and Self-Assembly Research: _ Biopharmaceutical Formulation _ Crystallization _ Molecular Theory and Simulation 2

CPE World Class Faculty MIT Practice School (established 1916) MIT Singapore T. Alan Hatton Michael KC Tam Ralph Landau Professor & Director, David H. Koch School of Chemical Engineering Practice Professor of Mechanical & Production Engineering, Nanyang Technological University Research: _ Transport phenomena _ Separation processes _ Stimuli- responsive polymers, gels and nanoparticles _ Stimuli-responsive fullerene and microgel systems _ Nano-structured systems from templating process. _ Enhanced drug delivery systems Founding Fellow, American Institute for Medical and Biological Engineering 3

CPE World Class Faculty Singapore v Ching, Chi Bun [Dean, Ch. BE, NTU ] v Lee, Jim Yang [Professor, Ch. BE, NUS] v Loh, Teck Peng [Professor of Chemistry, NTU] v v Li, Zhi [Associate Professor, Ch. BE, NUS] v MIT Rajagopalan, Raj [Co-Chair, SMA Chemical and Pharmaceutical Engineering and Head, Dept. of Chemical & Biomolecular Engineering] v Saeys, Mark [Assistant Professor, Ch. BE, NUS] v Professor of Chemistry] v v v Yap, Miranda [Exec. Dir. BTI; Professor, NUS] v Ying, Jackie [Exec. Dir. IBN; Adjunct Professor, NUS] Hatton, T. Alan [Ralph Landau Professor and Director, David H. Koch School of Chemical Engineering Practice] v Smith, Kenneth A. [Edwin R. Gilliland Professor of Chemical Engineering] v Stephanopoulos, Greg [Bayer Professor of Chemical Engineering] v Trout, Bernhardt L. [Co-Chair, SMA Chemical and Pharmaceutical Engineering and Associate Professor of Chemical Engineering] Too, Heng-Phon [Prof. of Biochemistry, NUS] v Doyle, Patrick S. [Charles and Hilda Roddey Assistant Professor of Chemical Engineering] Tam, KC Michael [Prof. of Mechanical & Production Engineering, NTU] Buchwald, Stephen L. [Camille Dreyfus v Wang, Daniel I. C. [Institute Professor of Chemical Engineering] 4

Motivation CPE v Importance of Singapore’s Chemical and Pharmaceuticals Sector: ØS$ 14 billion/year Ø 28% of Singapore’s Manufacturing Output in 2004 Ø 7. 8% of Singapore’s GDP in 2004 v Needs for Chemical and Pharmaceuticals Sector: üTop Technical Leaders üInnovative New Technologies v Objective: Educate Top Technical Leaders and Develop Innovative New High-Value-Added Technologies for 5 Chemical and Pharmaceutical Industries

Biomedical Research in Singapore CPE v Many Centers and Institutes already established ü Institute of Molecular and Cell Biology (1990) ü Institute of Agriculture Biotechnology (1995) ü Bioprocessing Technology Institute (1995) ü Centre for Natural Product Research (1998, privatized 2002) v BIOPOLIS: “city within city” ü Started construction (2001); dedicated (2003) ü Located close to National University of Singapore ü Self contained environment: laboratories, incubators, living quarters, restaurants, entertainment, MTR station, 6 etc.

Biopolis: A ‘Hot-bed’ for R&D CPE Institute of Bioengineering and Nanotechnology - Part of SMA-2 Corporate Research Facility B Ministry of Education Institute of Molecular & Cell Biology Bioinformatics Institute Bioprocessing Technology Institute - Part of SMA-2 Genome Institute of Singapore Corporate Research Facility A Institute of Chemical and Engineering Sciences (ICES) - Located at Jurong Island - Part of SMA-2 4 Phase 1: 184, 524 sqm ä Nov 2003 Completion ä Common areas include retail outlets, housing, and entertainment 4 Biomedical Complex ä Public R&D Centers (BII, BTI, GIS, IBN, IMB) ä Corporate R&D Centers © Singapore Economic Development Board, 2002 4 Shared R&D Facilities ä Shared R&D equipment ä Shared utilities ä Shared animal facility 7

Pharmaceutical and Chemical Research and Production in Singapore CPE v 165 Pharmaceutical Companies in Singapore v. Major ones include üGSK üPfizer üSchering-Plough üMerck v. Chemical Companies include üDow Chemical üShell 8

MIT CPE v Mission: “To advance knowledge and educate students in science, technology, and other areas of scholarship that will best serve the nation and the world in the 21 st century. ” v MIT ranked No. 1 in engineering by the U. S. News & World Report for its programs in aeronautics and astronautics, chemical engineering, computer engineering, electrical engineering, materials sciences and mechanical engineering. 9

Educational Programme CPE Ø Dual Master’s Degrees for 13 students per year with 18 month timeline: ü NUS Master’s Degree ü MIT Master’s Degree (We offer only one type of Master’s Degree at MIT, and SMA-2 students are in the same degree program together with all other MIT Master’s students. ) Ø Dual Ph. D/Master’s for 3 students per year with a 4 year timeline: ü MIT Master’s Degree (We offer only one type of Master’s Degree at MIT, and SMA-2 students are in the same degree program together with all other MIT Master’s students. ) ü NUS Ph. D (jointly supervised by Singapore and MIT faculty) Ø Direct Ph. D for 4 students/yr admitted directly to Ph. D: ü NUS or NTU Ph. D (all dissertations will be jointly supervised by NUS/NTU faculty and MIT faculty) 10

SMA-2 Dual Master’s Programme CPE (Switched for half of students) July/Aug. at MIT 1. Reaction Engineering 2. Systems Engineering Semester 1 Fall at MIT Semester 2 June-Aug. Semester 3 Spring Summer Fall at NUS at Practice School 1. Thermodynamics 2. Transport 3. Mathematics 4. Applied Chemistry 4 Electives Advanced Graduate-Level Coursework Laboratory Attachments Company 1 Company 2 Practice School projects instead of thesis research Master of Science in Chemical Engineering 11

CPE The David H. Koch School of Chemical Engineering Practice T. Alan Hatton, Director Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 Tel: +1 617 253 4588 E-Mail: tahatton@mit. edu http: //web. mit. edu/cheme/graduate/practice/index. html 12

MIT Master’s Program: “Practice School” CPE Ø Students take core graduate courses during one semester at MIT and a second semester in Singapore Ø In lieu of a Master’s thesis, students perform consulting projects at Practice School Stations located in Corporations and Research Institutes Ø Focus is on leadership and problem solving Ø MIT faculty resident on-site direct the Practice School Stations Ø Alumni are leaders in the chemical and pharmaceutical industries 13

The Practice School CPE v Different Paradigm for Technical Education: Training Technical Leaders Ø Ø Not a summer job or a traditional student internship/industrial attachment Leadership oriented technical training Project team focus to deliver solutions to company problems, as consultants Station Director - Resident MIT faculty for programme management v MIT Programme has 90 -Year History of Success - Professional success of many alumni attributed to Practice School training: ü Ralph Landau (Halcon International, Oxirane) ü Gerry Mc. Affee (CEO Gulf Oil) ü David Koch (Koch Industries) ü John Haas (Rohm and Haas) ü Sam Bodman (Fidelity, Cabot, US Secretary of Energy) ü Fred von Gottberg (Cabot, VP Research and Development) ü Lloyd Johnston (Alkermes, VP) 14

The Practice School Projects CPE Semester 3 Stations Company 1 6 -9 students/session at field stations Company 2 Work performed for a Client u u Objectives clearly defined High value-added results (Up to Millions of dollars per year) Students work in teams of 2 or 3 u u Designated team leader– Leadership training Students divide the work Four-Week schedule u Project 1 2 Project 3 4 u u u Designed for high output Work highly organized and planned Scheduled progress reports, oral and written Documentation, proprietary Supervision and monitoring 8 weeks at Company 1 8 weeks at Company 2 u u MIT faculty on-site as Station Director Reporting to and consulting with client 15

CPE Project Calendar Spring Stations Company orientation and safety 8 weeks at Company 1 Mon 8 weeks at Company 2 Tues Wed Thurs Fri Project Definition and Planning Project 4 Project 3 Project 2 Project 1 Sun Presentations Project Execution Draft Report Sat Weekend Activities Fall Final Report 16

Recent Practice School Stations in the US CPE Plug. Power Schenectady NY Cargill Minneapolis MN Cabot Corp Billerica MA Johns Manville Toledo OH Alkermes/AIR Cambridge MA Novartis East Hanover NJ Suffern NY Masterfoods, Inc Vernon CA, Reno NV General Mills Minneapolis MN Albuquerque NM, Buffalo NY Cincinnati OH, Lodi CA Cedar Rapids IA M&M Mars, Inc Hackettstown, NJ Elizabethtown, PA GE Plastics Mt. Vernon IN 17

Practice School Around the World BP Chemicals Hull, U. K. Grangemouth, Scotland Rhone Poulenc. Lyon, France Novartis Basle, Switzerland CPE M&M Mars, Inc Students traveled to Europe and Australia Mitsubishi Chemical Corp. Mizushima, Japan GSK Harlow/Ware U. K. Cork, Ireland Independent Practice School Program KMITT, Bangkok, Thailand Consortium of Companies SMA, Singapore 18

Summary of Benefits CPE v Unique Technical Leadership Training Program ü Has generated several generations of technical leaders in the chemical industry ü Increases technical objectivity and sharpens communicative and supervisory skills ü Shortens activation period for professional activity 19

Eligibility CPE q Applicants must have received a Bachelor’s degree by the commencement of the academic year. - Need to demonstrate an excellent undergraduate background in: (very important!) q Reactor Engineering (e. g. textbook by Fogler or equivalent) q Thermodynamics (e. g. textbook by Smith, van Ness, Abbott or eq. ) q Transport (e. g. textbook by Bird, Stewart, Lightfoot or equivalent) - Need TOEFL (for non-native English speakers) and GRE q Applicants are admitted independently and separately to both MIT and NUS/NTU q Evidence of past accomplishments, academic potential, leadership potential, the potential for producing innovative research, creativity, and morals and ethics (but not 20 exclusively) are considered.

Graduate Fellowship CPE Support v. SMA Graduate Fellowship provides full support for: üFull tuition at both NUS/NTU, and MIT üHousing allowance whilst resident at MIT üStipend üTravel between Singapore and MIT, and between Singapore and Practice School stations 21

Application Procedure CPE v To apply to CPE, the following application forms must be submitted: q MIT Application Form: Department of Chemical Engineering (to be submitted to MIT) Application deadline: January 2, 2007: http: //student. mit. edu/cgi-bin/agapwreq. sh? I_Dept=10 q SMA Application Forms (to be submitted to the Singapore-SMA Office) Application deadline: February 15, 2007: http: //web. sma. nus. edu. sg/admission_forms/ q Fellowship Application Form (to be submitted to the Singapore-SMA Office) Application deadline: February 15, 2007: http: //web. mit. edu/sma/students/admissions/documents/fellowapp. pdf v For more information, see: Ø http: //web. mit. edu/sma/students/programmes/cpe. htm 22